Meta-analysis of the Efficacy and Safety of Kangfuxin Combined with Adenosine Monophosphate in the Treatment of Paediatric Herpetic Stomatitis

Hao FAN; Xuejiao WU; Zhenyu CHENG; Xiubai TANG; Xing LIU; Hui HUANG

doi:10.12259/j.issn.2095-610X.S20250409

Volume 46 Issue 4

Apr. 2025

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2025 > 46(4): 67-76

Hao FAN, Xuejiao WU, Zhenyu CHENG, Xiubai TANG, Xing LIU, Hui HUANG. Meta-analysis of the Efficacy and Safety of Kangfuxin Combined with Adenosine Monophosphate in the Treatment of Paediatric Herpetic Stomatitis[J]. Journal of Kunming Medical University, 2025, 46(4): 67-76. doi: 10.12259/j.issn.2095-610X.S20250409

Citation:

Hao FAN, Xuejiao WU, Zhenyu CHENG, Xiubai TANG, Xing LIU, Hui HUANG. Meta-analysis of the Efficacy and Safety of Kangfuxin Combined with Adenosine Monophosphate in the Treatment of Paediatric Herpetic Stomatitis[J]. Journal of Kunming Medical University, 2025, 46(4): 67-76. doi: 10.12259/j.issn.2095-610X.S20250409

Citation:

Hao FAN, Xuejiao WU, Zhenyu CHENG, Xiubai TANG, Xing LIU, Hui HUANG. Meta-analysis of the Efficacy and Safety of Kangfuxin Combined with Adenosine Monophosphate in the Treatment of Paediatric Herpetic Stomatitis[J]. Journal of Kunming Medical University, 2025, 46(4): 67-76. doi: 10.12259/j.issn.2095-610X.S20250409

PDF( 1070 KB)

Meta-analysis of the Efficacy and Safety of Kangfuxin Combined with Adenosine Monophosphate in the Treatment of Paediatric Herpetic Stomatitis

doi: 10.12259/j.issn.2095-610X.S20250409

1.
Pharmacy Department，Northeast Yunnan Center Hospital，Zhaotong Yunnan 657099
2.
Pharmacy Department，Yiliang County People's Hospital，Zhaotong Yunnan 657699
3.
Pharmacy Department，The Third People’s Hospital of Kunming，Kunming Yunnan 650041，China

Received Date: 2024-12-22
Available Online: 2025-03-26
Publish Date: 2025-04-25

Abstract

Abstract

Objective To systematically evaluate the safety and efficacy of Kangfuxin liquid combined with adenosine monophosphate in the treatment of paediatric herpetic stomatitis. Methods Randomised controlled trials （RCTs） of Kangfuxin liquid combined with adenosine monophosphate for the treatment of paediatric herpetic stomatitis were searched in various databases, and Meta-analysis was performed using RevMan 5.4 software. Results A total of 12 RCTs with a sample size of 1,094 cases were included. Meta-analysis showed that the combination of Kangfuxin liquid with adenosine monophosphate significantly increased [RR = 1.21, 95%CI （1.16, 1.28）, P < 0.00001] the overall clinical efficacy rate of paediatric herpetic stomatitis. Compared with the conventional antiviral treatment group with adenosine monophosphate, the incidence of adverse events was lower in the Kangfuxin liquid group [RR = 0.26, 95%CI （0.14, 0.51）, P < 0.00001]. In addition, the Kangfuxin liquid group could effectively shorten the time for herpes disappearance （skin lesion healing）, pain disappearance, fever reduction, salivation disappearance and recovery of diet （P < 0.05）, and had advantages in promoting the recovery of lymphocytes （CD3⁺, CD4⁺, CD8+, and CD4⁺/CD8⁺）, serological levels （CRP, TNF-α, WBC, IL-10, VEGF, EGF, and IL-6）（P < 0.05）. Conclusion Kangfuxin liquid combined with adenosine monophosphate has the better efficacy and safety in the treatment of paediatric herpetic stomatitis, and has advantages in shortening the symptomatic recovery time and improving the indicators of lymphocyte and serological levels in paediatric herpetic stomatitis.
- Kangfuxin,
- Adenosine monophosphate,
- Herpes stomatitis,
- Meta-analysis

FullText(HTML)

References(20)

References

[1]	蔡秋晗,李新民,蔡越冬,等. 口炎清颗粒治疗小儿疱疹性口炎(阴虚风热证)的随机对照、多中心临床研究[J]. 药物评价研究,2020,43(9):1792-1796.
[2]	江载芳,申昆玲,沈颖. 诸福棠实用儿科学[M]. 第8版. 北京: 人民卫生出版社,2015:831-832
[3]	王辉,陆瑶伽. 单磷酸阿糖腺苷注射剂联合溶菌酶肠溶片治疗小儿疱疹性口腔炎的临床研究[J]. 中国临床药理学杂志,2017,33(14):1311-1313.
[4]	邓华夏,朱月圆,邓传玺. 康复新液防治口腔疾病的最新研究进展[J]. 现代医学与健康研究电子杂志,2021,5(14):136-139.
[5]	谢丹丹,卢燕香,喻春梅. 甘草泻心汤联合康复新液与Ara-AMP对疱疹性口腔炎的疗效及影响[J]. 实用中西医结合临床,2024,24(9):34-37.
[6]	王虹,张昕,胡爱萍,等. 康复新液对疱疹性口腔炎患儿的疗效观察[J]. 现代医学与健康研究(电子版),2023,7(6):95-97. doi: 10.3969/j.issn.2096-3718.2023.06.031
[7]	宋娜,宋均琴. 单磷酸阿糖腺苷与康复新液治疗小儿疱疹性口腔炎的效果[J]. 中国卫生标准管理,2022,13(16):129-133. doi: 10.3969/j.issn.1674-9316.2022.16.028
[8]	潘俊文. 单磷酸阿糖腺苷联合康复新液对小儿疱疹性口腔炎的治疗价值研究[J]. 母婴世界,2021,1(17):99.
[9]	赵越,高杰. 康复新液联合单磷酸阿糖腺苷治疗小儿疱疹性口腔炎的疗效和对T淋巴细胞百分比的影响[J]. 中国妇幼保健,2021,36(16):3755-3758.
[10]	丁丽萍. 康复新液联合溶菌酶、单磷酸阿糖腺苷对小儿疱疹性口腔炎的疗效及炎症因子影响[J]. 医学食疗与健康,2021,19(25):210-211.
[11]	崔小会. 单磷酸阿糖腺苷联合康复新液治疗疱疹性口腔炎临床疗效分析[J]. 黑龙江中医药,2020,49(2):32-33.
[12]	李香君,沈丹,李艳敏,等. 康复新液联合单磷酸阿糖腺苷、溶菌酶治疗小儿疱疹性口腔炎疗效及对血清炎症因子的影响[J]. 中华中医药学刊,2019,37(5):1222-1224.
[13]	全翠芬. 单磷酸阿糖腺苷联合康复新液治疗小儿疱疹性口腔炎[J]. 深圳中西医结合杂志,2018,28(17):139-140.
[14]	周波. 康复新液与单磷酸阿糖腺苷联合溶菌酶治疗小儿疱疹性口腔炎疗效及对血清炎症因子的影响评价[J]. 养生保健指南,2018,1(3):302-302. doi: 10.3969/j.issn.1006-6845.2018.03.289
[15]	肖雷,邹学红. 康复新液联合单磷酸阿糖腺苷、溶菌酶治疗小儿疱疹性口腔炎疗效及对血清炎症因子的影响[J]. 现代中西医结合杂志,2017,26(35):3951-3953. doi: 10.3969/j.issn.1008-8849.2017.35.013
[16]	陈学锋,伍雄英. 单磷酸阿糖腺苷联合康复新液治疗小儿疱疹性口腔炎临床体会[J]. 今日健康,2015,14(10):143-144.
[17]	Boitsaniuk S,Levkiv M,Fedoniuk L,et al. Acute herpetic stomatitis: Clinical manifestations,diagnostics and treatment strategies[J]. Wiad Lek,2022,75(1):318-323.
[18]	Marzuqi N,Taqwim A,Vitasari N,et al. Management of acute primary herpetic gingivo-stomatitis in children[J]. IJDM,2019,2(2):29-31.
[19]	王钦,刘克娜,孔彩华,等. 美洲大蠊提取物的活性成分及其抗氧化应激的研究现状[J]. 中华中医药学刊,2021,39(7):124-127.
[20]	白春昕. 单磷酸阿糖腺苷联合康复新液治疗小儿疱疹性口腔炎的临床疗效分析[J]. 中国现代药物应用,2020,14(2):182-184.

Relative Articles(20)

Relative Articles

[1]	Lizi ZHANG, Xinping YANG, Guangguang FANG. Erector Spinae Plane Block for Postoperative Analgesia in Breast Cancer: A Meta-Analysis. Journal of Kunming Medical University, 2025, 46(3): 148-158. doi: 10.12259/j.issn.2095-610X.S20250322
[2]	Shuang FANG, Libo ZHU, Ling LIU, Yanhua XU, Xue HU. Meta-analysis of the Impact of Early Enteral Nutrition on the Clinical Outcomes of Very Low Birth Weight Premature Infants. Journal of Kunming Medical University, 2024, 45(9): 129-135. doi: 10.12259/j.issn.2095-610X.S20240920
[3]	Ya LUO, Yanting YU, Xue ZHANG, Zhongjuan WANG. A Meta-analysis of the Risk of Secondary Infection of Tocilizumab in the Treatment of COVID-19. Journal of Kunming Medical University, 2024, 45(2): 57-64. doi: 10.12259/j.issn.2095-610X.S20240208
[4]	Leijing RAN, Shaohua WANG, Lintong LI, Li GUI. A Meta-analysis of the Effect of Adjuvant Probiotics in Patients with Osteoporosis. Journal of Kunming Medical University, 2024, 45(2): 65-76. doi: 10.12259/j.issn.2095-610X.S20240209
[5]	Qingmei YU, Tao SHI, Hongxue GUAN, Yujun MAO, Zhaoyi LI, Jiao YANG. Prevalence and Influence Factors of Renal Function Impairment in Patients Following Radical Cystectomy：A Systematic Review and Meta-analysis. Journal of Kunming Medical University, 2024, 45(9): 83-90. doi: 10.12259/j.issn.2095-610X.S20240913
[6]	Caini ZHANG, Ya LI. A Meta-analysis of the Efficacy and Safety of Camrelizumab Combined with Chemotherapy in the Treatment of Non-small Cell Lung Cancer. Journal of Kunming Medical University, 2024, 45(6): 75-84. doi: 10.12259/j.issn.2095-610X.S20240610
[7]	Xing LIU, Weixian LI, Yan WU, Xuejiao WU, Xiaodie YAO, Jie CHEN, Lingjun SHEN, Hao FAN. Efficacy and Safety of Jingangteng Capsules Combined with Antimicrobial Drugs in the Treatment of Chronic Pelvic Inflammatory Disease: A Meta-analysis. Journal of Kunming Medical University, 2024, 45(4): 81-91. doi: 10.12259/j.issn.2095-610X.S20240412
[8]	Huaping WANG, Dingyun YOU, Yanhong YANG, Bowen CHEN, Yue HUAN, Rui LIAO. A Meta Analysis of the Incidence of Stillbirth in Pregnant and Postpartum Women in China from 1994 to 2020. Journal of Kunming Medical University, 2023, 44(9): 15-24. doi: 10.12259/j.issn.2095-610X.S20230907
[9]	Sun Xing Yun , Liu Xia , Meng Fan Xing , Wang Le , Wang Feng Li . . Journal of Kunming Medical University, 2020, 41(08): 18-26.
[10]	Yang Yan Hong , You Ding Yun , Huang Ying , Liao Rui . . Journal of Kunming Medical University, 2019, 40(09): 36-40.
[11]	Jie Chun Lin , Huang Tao , Teng Zhao Wei , Bu Jun Hui , Li Meng Zhou , Zhang Jing. . Journal of Kunming Medical University, 2019, 40(04): 91-96.
[12]	Lin Yun Ke , Lin Yun Hong . . Journal of Kunming Medical University, 2019, 40(10): 50-56.
[13]	Weng Xiao Chun , Li Chun , Zhou Song Lan , Tang Zhe , Peng Bao Kun . Meta Analysis of Effectiveness of Vacuum Sealing Drainage in the Treatment of Diabetic Foot Ulcer. Journal of Kunming Medical University, 2017, 38(04): 80-83.
[14]	Zhang Wei . Meta Analysis of ADAM33 T1，S2 Polymorphism and the Susceptibility of Bronchial Asthma in China. Journal of Kunming Medical University,
[15]	Peng Chun . . Journal of Kunming Medical University,
[16]	Ke Zi Li . . Journal of Kunming Medical University,
[17]	Deng Peng Peng . . Journal of Kunming Medical University,
[18]	Zhou Jie . . Journal of Kunming Medical University,
[19]	. Sanchinoside for Diabetic Peripheral Neuropathy:A Meta Analysis. Journal of Kunming Medical University,
[20]	. . Journal of Kunming Medical University,