Correlation Analysis between Coagulation and Fibrinolysis in Early Pregnancy and Gestational Diabetes in Women with Different BMI before Pregnancy

Yan CHI; Junxian LI; Ling ZHAO; Wenyi LI; Tingyu KE

doi:10.12259/j.issn.2095-610X.S20250410

Volume 46 Issue 4

Apr. 2025

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Yan CHI, Junxian LI, Ling ZHAO, Wenyi LI, Tingyu KE. Correlation Analysis between Coagulation and Fibrinolysis in Early Pregnancy and Gestational Diabetes in Women with Different BMI before Pregnancy[J]. Journal of Kunming Medical University, 2025, 46(4): 77-82. doi: 10.12259/j.issn.2095-610X.S20250410

Citation:

Yan CHI, Junxian LI, Ling ZHAO, Wenyi LI, Tingyu KE. Correlation Analysis between Coagulation and Fibrinolysis in Early Pregnancy and Gestational Diabetes in Women with Different BMI before Pregnancy[J]. Journal of Kunming Medical University, 2025, 46(4): 77-82. doi: 10.12259/j.issn.2095-610X.S20250410

Citation:

Yan CHI, Junxian LI, Ling ZHAO, Wenyi LI, Tingyu KE. Correlation Analysis between Coagulation and Fibrinolysis in Early Pregnancy and Gestational Diabetes in Women with Different BMI before Pregnancy[J]. Journal of Kunming Medical University, 2025, 46(4): 77-82. doi: 10.12259/j.issn.2095-610X.S20250410

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Correlation Analysis between Coagulation and Fibrinolysis in Early Pregnancy and Gestational Diabetes in Women with Different BMI before Pregnancy

doi: 10.12259/j.issn.2095-610X.S20250410

Department of Endocrinology，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2024-09-06
Available Online: 2025-04-02
Publish Date: 2025-04-25

Abstract

Abstract

Objective To explore the relationship between the coagulation and fibrinolysis function in the early pregnancy and the occurrence of gestational diabetes mellitus （GDM） in women with different pre pregnancy body mass indexes （BMI）. Methods 290 pregnant women undergoing the prenatal check ups at the Second Affiliated Hospital of Kunming Medical University from September 2023 to February 2024 were selected. Pre pregnancy BMI, age, family genetic history, parity, parity, and early pregnancy coagulation and fibrinolysis function test results were collected. Based on whether GDM had occurred, they were divided into GDM group （n = 72） and non GDM group （n = 218）, and further divided into low weight GDM group （n = 8）, low weight non GDM group （n = 29）, normal weight GDM group （n = 39）, normal weight non GDM group （n = 145）, overweight/obesity GDM group （n = 25）, overweight/obesity non GDM group （n = 44） based on pre pregnancy BMI. Basic data comparison was conducted on the total population and BMI groups. Independent sample t-test or Mann Whitney U test was used for quantitative data, and chi square test or Fisher's exact probability method was used for qualitative data. Multivariate logistic regression was used to correct the influencing factors. Results After adjusting the confounding factors such as age, family history, and pre pregnancy BMI, APTT was negatively correlated with the occurrence of GDM in the overall population （P < 0.05, OR = 0.840）, while FIB was positively correlated with GDM （P < 0.01, OR = 2.598）. In low body weight recombination, APTT was negatively correlated with GDM （P < 0.05, OR = 0.483）, FIB was positively correlated with GDM （P < 0.05, OR=82.501）, while there was no significant correlation between APTT, FIB and GDM after adjusting the age, family history, and pre pregnancy BMI; In the normal weight group, APTT was negatively correlated with GDM （P < 0.01, OR = 0.786） and FIB was positively correlated with GDM （P < 0.05, OR = 2.413）. However, after adjusting the age, family history, and pre pregnancy BMI, APTT remained negatively correlated with GDM （P < 0.05, OR = 0.812） and FIB remained positively correlated with GDM （P < 0.05, OR = 2.391）; In the overweight/obese group, TT was negatively correlated with GDM （P < 0.05, OR = 0.510）, while there was no significant correlation between TT and GDM after adjusting the age, family history, and pre pregnancy BMI. Conclusion In the normal weight population, APTT is negatively correlated with the occurrence of GDM, while FIB is positively correlated with the occurrence of GDM; In the low weight and overweight/obese populations, coagulation and fibrinolysis related indicators are greatly influenced by BMI and have no significant correlation with the occurrence of GDM.
- Coagulation function,
- Gestational diabetes mellitus,
- Fibrinogen,
- Activated partial thromboplastin time,
- Fibrinolytic function

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References(19)

References

[1]	Sadowska A,Poniedziałek-Czajkowska E,Mierzyński R. The role of the FGF19 family in the pathogenesis of gestational diabetes: A narrative review[J]. International Journal of Molecular Sciences,2023,24(24):17298. doi: 10.3390/ijms242417298
[2]	Kautzky-Willer A,Winhofer Y,Kiss H,et al. Gestational diabetes mellitus (update 2023)[J]. Wiener Klinische Wochenschrift,2023,135(Suppl 1):115-128.
[3]	Wang H,Li N,Chivese T,et al. IDF diabetes atlas: Estimation of global and regional gestational diabetes mellitus prevalence for 2021 by international association of diabetes in pregnancy study group’s criteria[J]. Diabetes Research and Clinical Practice,2022,183(1):109050. doi: 10.1016/j.diabres.2021.109050
[4]	王芳,倪晓绒,王榕,等. 贵州苗族孕妇膳食炎症指数与妊娠期糖尿病发生风险的队列研究[J]. 现代预防医学,2024,51(19):3523-3528.
[5]	Lovell H,Mitchell A,Ovadia C,et al. A multi-centered trial investigating gestational treatment with ursodeoxycholic acid compared to metformin to reduce effects of diabetes mellitus (GUARD): A randomized controlled trial protocol[J]. Trials,2022,23(1):571. doi: 10.1186/s13063-022-06462-y
[6]	Majewska A,Godek B,Bomba-Opon D,et al. Association between intrahepatic cholestasis in pregnancy and gestational diabetes mellitus. A retrospective analysis[J]. Ginekologia Polska,2019,90(8):458-463.
[7]	Liao T,Xu X,Zhang Y,et al. Interactive effects of gestational diabetes mellitus and maximum level of total bile acid in maternal serum on adverse pregnancy outcomes in women with intrahepatic cholestasis of pregnancy[J]. BMC Pregnancy and Childbirth,2023,23(1):326.
[8]	武亚星,姚晓燕,周立芳,等. 中国2012—2020年妊娠期糖尿病患病率的Meta分析[J]. 现代医学,2023,51(7):879-884. doi: 10.3969/j.issn.1671-7562.2023.07.001
[9]	Zhu Y,Zhang C. Prevalence of gestational diabetes and risk of progression to type 2 diabetes: A global perspective[J]. Current Diabetes Reports,2016,16(1):7.
[10]	Bernea E G,Suica V I,Uyy E,et al. Exosome proteomics reveals the deregulation of coagulation,complement and lipid metabolism proteins in gestational diabetes mellitus[J]. Molecules,2022,27(17):5502. doi: 10.3390/molecules27175502
[11]	Teliga-Czajkowska J,Sienko J,Zareba-Szczudlik J,et al. Influence of glycemic control on coagulation and lipid metabolism in pregnancies complicated by pregestational and gestational diabetes mellitus[J]. Advances in Experimental Medicine and Biology,2019,1176(1):81-88.
[12]	Song X,Wang C,Wang T,et al. Obesity and risk of gestational diabetes mellitus: A two-sample Mendelian randomization study[J]. Diabetes Research and Clinical Practice,2023,197(1):110561.
[13]	Szukiewicz D. Molecular mechanisms for the vicious cycle between insulin resistance and the inflammatory response in obesity[J]. International Journal of Molecular Sciences,2023,24(12):9818.
[14]	中华人民共和国国家卫生健康委员会医政司. 肥胖症诊疗指南(2024年版)[J]. 中华消化外科杂志,2024,23(10):1237-1260. doi: 10.3760/cma.j.cn115610-20241017-00455
[15]	American Diabetes Association Professional Practice Committee. Diagnosis and classification of diabetes: Standards of care in diabetes—2024[J]. Diabetes Care,2023,47(Suppl 1):S20-S42.
[16]	Santoro R C,Molinari A C,Leotta M,et al. Isolated prolongation of activated partial thromboplastin time: Not just bleeding risk![J]. Medicina,2023,59(6):1169. doi: 10.3390/medicina59061169
[17]	Akbulut A C, Pavlic A, Petsophonsakul P, et al. Vitamin K2 needs an RDI separate from vitamin K1[J]. Nutrients,2020,12(6):1852.
[18]	Qadi H H,Bendary M A,Almaghrabi S Y,et al. Exploring the therapeutic potential of apigenin in obesity-associated fibrinolytic dysfunction: Insights from an animal study[J]. Cureus,2023,15(6):e40943.
[19]	Wang C,Wei Y,Zhang X,et al. A randomized clinical trial of exercise during pregnancy to prevent gestational diabetes mellitus and improve pregnancy outcome in overweight and obese pregnant women[J]. American Journal of Obstetrics and Gynecology,2017,216(4):340-351. doi: 10.1016/j.ajog.2017.01.037

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