Prognostic Value of Pan-immune Inflammatory Values in Patients with Ischemic Stroke Treated with Intravascular Intervention Combined with Tirofiban

Yuting CHEN; Jun PU; Bin YAN; Renhua XIE

doi:10.12259/j.issn.2095-610X.S20250415

Volume 46 Issue 4

Apr. 2025

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Article Navigation > Journal of Kunming Medical University > 2025 > 46(4): 115-122

Yuting CHEN, Jun PU, Bin YAN, Renhua XIE. Prognostic Value of Pan-immune Inflammatory Values in Patients with Ischemic Stroke Treated with Intravascular Intervention Combined with Tirofiban[J]. Journal of Kunming Medical University, 2025, 46(4): 115-122. doi: 10.12259/j.issn.2095-610X.S20250415

Citation:

Yuting CHEN, Jun PU, Bin YAN, Renhua XIE. Prognostic Value of Pan-immune Inflammatory Values in Patients with Ischemic Stroke Treated with Intravascular Intervention Combined with Tirofiban[J]. Journal of Kunming Medical University, 2025, 46(4): 115-122. doi: 10.12259/j.issn.2095-610X.S20250415

Citation:

Yuting CHEN, Jun PU, Bin YAN, Renhua XIE. Prognostic Value of Pan-immune Inflammatory Values in Patients with Ischemic Stroke Treated with Intravascular Intervention Combined with Tirofiban[J]. Journal of Kunming Medical University, 2025, 46(4): 115-122. doi: 10.12259/j.issn.2095-610X.S20250415

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Prognostic Value of Pan-immune Inflammatory Values in Patients with Ischemic Stroke Treated with Intravascular Intervention Combined with Tirofiban

doi: 10.12259/j.issn.2095-610X.S20250415

Yuting CHEN^{1
,
,},
Jun PU²,
Bin YAN¹,
Renhua XIE³

1.
Department of Cerebrovascular Diseases，The First People's Hospital of Zhaotong，Zhaotong Yunnan 657000
2.
The First Ward of Neurosurgery Department，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650100
3.
The Second Ward of Neurosurgery Department，363 Hospital，Chengdu Sichuan 611730，China

Received Date: 2024-12-10
Available Online: 2025-04-05
Publish Date: 2025-04-25

Abstract

Abstract

Objective To investigate the predictive value of pan-immune inflammatory values （PIV） in the prognosis of patients with ischemic stroke （AIS） treated with intravascular intervention combined with tirofiban. Methods 102 AIS cases admitted to the Department of Neurology of the First People's Hospital of Zhaotong from January 2019 to December 2023 and treated with intravascular intervention combined with Tirofiban were selected as the study objects. The patients were divided into the mild group （n = 9）, moderate group （n = 45） and severe group （n = 48） according to the score of NIHSS after the admission. According to the mRS 90 days after the treatment, the cases were divided into the good prognosis group （n = 63） and poor prognosis group （n = 38）. Data were collected and analyzed. The predictive value of PIV level in patients with ischemic stroke treated with intravascular intervention combined with tirofiban was evaluated by ROC. The risk factors of adverse outcomes in patients with ischemic stroke treated with intravascular intervention combined with tirofiban were investigated by multivariate Logistic regression. Results A total of 102 patients with ischemic stroke were included. The PIV level in the good prognosis group 331.1（221.9, 662.7） was lower than that in the poor prognosis group 1025.7（451.5, 1841.3）（P < 0.05）. PIV level in the severe group was higher than that in the mild and moderate groups, and PIV level in the moderate group was higher than that in the mild group （P < 0.05）. The AUC （95%CI） of PIV for predicting adverse outcomes of intravascular intervention combined with tirofiban in patients with ischemic stroke was 0.750 （95%CI 0.654～0.831）, the cut-off point was 834.92, the specificity was 85.71% and the sensitivity was 65.79%. NIHSS score > 18 （OR = 5.944 95%CI 2.011～19.137）, PIV > 834.92 （OR = 4.863, 95%CI 1.410～18.685） were the risk factors for the poor outcome of intravascular intervention combined with tirofiban in patients with ischemic stroke （P < 0.05）. Conclusion Elevated PIV is closely related to the poor outcomes in patients with ischemic stroke treated with intravascular intervention combined with Tirofiban. High PIV and NIHSS scores are both risk factors for the poor prognosis in patients with ischemic stroke, and can be used as the sensitive indicators for the early identification.
- Pan-immune inflammatory value,
- Ischemic stroke,
- Intravascular intervention,
- Tirofiban,
- Disease outcome,
- Predictive value

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References(24)

References

[1]	Jolugbo P,Ariëns R A. Thrombus composition and efficacy of thrombolysis and thrombectomy in acute ischemic stroke[J]. Stroke,2021,52(3):1131-1142. doi: 10.1161/STROKEAHA.120.032810
[2]	Qiu Y M,Zhang C L,Chen A Q,et al. Immune cells in the BBB disruption after acute ischemic stroke: Targets for immune therapy?[J]. Frontiers in Immunology,2021,12(2):67-81.
[3]	Mendelson S J,Prabhakaran S. Diagnosis and management of transient ischemic attack and acute ischemic stroke: A review[J]. JAMA,2021,325(11):1088-1098. doi: 10.1001/jama.2020.26867
[4]	Wang J,Zou D. Tirofiban-induced thrombocytopenia[J]. Annals of Medicine,2023,55(1):223-231.
[5]	Phipps M S,Cronin C A. Management of acute ischemic stroke[J]. BMJ,2020,12(8):368-375.
[6]	Zhu H,Hu S,Li Y,et al. Interleukins and ischemic stroke[J]. Frontiers in Immunology,2022,31(8):82-87.
[7]	Okyar Baş A,Güner M,Ceylan S,et al. Pan-immune inflammation value; A novel biomarker reflecting inflammation associated with frailty[J]. Aging Clinical and Experimental Research,2023,35(8):1641-1649. doi: 10.1007/s40520-023-02457-0
[8]	Li J,Qiu Y,Zhang C,et al. The role of protein glycosylation in the occurrence and outcome of acute ischemic stroke[J]. Pharmacological Research,2023,191(2):106-112.
[9]	Yang X C,Liu H,Liu D C,et al. Prognostic value of pan-immune-inflammation value in colorectal cancer patients: A systematic review and meta-analysis[J]. Frontiers in Oncology,2022,12(6):1036-1041.
[10]	Hendrix P,Melamed I,Collins M,et al. NIHSS 24 h after mechanical thrombectomy predicts 90-day functional outcome[J]. Clinical Neuroradiology,2022,32(2):401-406. doi: 10.1007/s00062-021-01068-4
[11]	Bogdanov L,Shishkova D,Mukhamadiyarov R,et al. Excessive adventitial and perivascular vascularisation correlates with vascular inflammation and intimal hyperplasia[J]. International Journal of Molecular Sciences,2022,23(20):121-128.
[12]	Liu C,Niu K,Xiao Q. Updated perspectives on vascular cell specification and pluripotent stem cell-derived vascular organoids for studying vasculopathies[J]. Cardiovascular Research,2022,118(1):97-114. doi: 10.1093/cvr/cvaa313
[13]	Shuai J,Gong Z,Huang L,et al. Effect of intravenous tirofiban vs placebo before endovascular thrombectomy on functional outcomes in large vessel occlusion stroke: The RESCUE BT randomized clinical trial[J]. JAMA,2022,328(6):543-553. doi: 10.1001/jama.2022.12584
[14]	Al-Salihi M M,Ayyad A,Al-Jebur M S,et al. Safety and efficacy of tirofiban in the management of stroke: A systematic review and meta-analysis of randomized controlled trials[J]. Clinical Neurology and Neurosurgery,2023,6(14):107-115.
[15]	Fan Q,Zhao Y,Zhang J,et al. Factors influencing early diagnosis and poor prognosis of dysphagia after senile ischemic stroke[J]. Journal of Molecular Neuroscience,2024,74(2):31-42. doi: 10.1007/s12031-024-02210-w
[16]	Murat B,Murat S,Ozgeyik M,et al. Comparison of pan‐immune‐inflammation value with other inflammation markers of long‐term survival after ST‐segment elevation myocardial infarction[J]. European Journal of Clinical Investigation,2023,53(1):138-147
[17]	Dolapoglu A,Avci E. Relationship between pan-immune-inflammation value and in major cardiovascular and cerebrovascular events in stable coronary artery disease patients undergoing on-pump coronary artery bypass graft surgery[J]. Journal of Cardiothoracic Surgery,2024,19(1):241-250. doi: 10.1186/s13019-024-02691-1
[18]	Lee L E,Ahn S S,Pyo J Y,et al. Pan-immune-inflammation value at diagnosis independently predicts all-cause mortality in patients with antineutrophil cytoplasmic antibody-associated vasculitis[J]. Clinical and Experimental Rheumatology,2021,39(2):88-93. doi: 10.55563/clinexprheumatol/m46d0v
[19]	Murad H. Short editorial neutrophil-to-lymphocyte ratio and abdominal aortic atherosclerosis among asymptomatic individuals [Z]. SciELO Brasil, 2022,30(17): 735-736
[20]	Zhang N,Tse G,Liu T. Neutrophil–lymphocyte ratio in the immune checkpoint inhibitors-related atherosclerosis[J]. European Heart Journal,2021,42(22):2215-2219. doi: 10.1093/eurheartj/ehab158
[21]	Lechner K,von Schacky C,McKenzie A L,et al. Lifestyle factors and high-risk atherosclerosis: Pathways and mechanisms beyond traditional risk factors[J]. European Journal of Preventive Cardiology,2020,27(4):394-406. doi: 10.1177/2047487319869400
[22]	Bugger H,Zirlik A. Anti-inflammatory strategies in atherosclerosis[J]. Hä mostaseologie,2021,41(6):433-442.
[23]	Wu X B,Huang L X,Huang Z R,et al. The lymphocyte-to-monocyte ratio predicts intracranial atherosclerotic stenosis plaque instability[J]. Frontiers in Immunology,2022,13(4):915-924.
[24]	Oggero S,de Gaetano M,Marcone S,et al. Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity[J]. Journal of Extracellular Vesicles,2021,10(6):1208-1212.

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