Influence of Nutrition Intervention on Quality of Life and Survival Prognosis of Patients with Locally Advanced Pancreatic Cancer

Shijun SHEN; Yamei YIN; Li SONG; Chunming XIANG; Heng LI

doi:10.12259/j.issn.2095-610X.S20250418

Volume 46 Issue 4

Apr. 2025

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Shijun SHEN, Yamei YIN, Li SONG, Chunming XIANG, Heng LI. Influence of Nutrition Intervention on Quality of Life and Survival Prognosis of Patients with Locally Advanced Pancreatic Cancer[J]. Journal of Kunming Medical University, 2025, 46(4): 136-142. doi: 10.12259/j.issn.2095-610X.S20250418

Citation:

Shijun SHEN, Yamei YIN, Li SONG, Chunming XIANG, Heng LI. Influence of Nutrition Intervention on Quality of Life and Survival Prognosis of Patients with Locally Advanced Pancreatic Cancer[J]. Journal of Kunming Medical University, 2025, 46(4): 136-142. doi: 10.12259/j.issn.2095-610X.S20250418

Citation:

Shijun SHEN, Yamei YIN, Li SONG, Chunming XIANG, Heng LI. Influence of Nutrition Intervention on Quality of Life and Survival Prognosis of Patients with Locally Advanced Pancreatic Cancer[J]. Journal of Kunming Medical University, 2025, 46(4): 136-142. doi: 10.12259/j.issn.2095-610X.S20250418

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Influence of Nutrition Intervention on Quality of Life and Survival Prognosis of Patients with Locally Advanced Pancreatic Cancer

doi: 10.12259/j.issn.2095-610X.S20250418

1.
Department of Hepatobiliary Surgery
2.
Department of Clinical Nutrition，Lincang People’s Hospital，Lincang Yunnan 677099，China

Received Date: 2024-11-20
Available Online: 2025-04-07
Publish Date: 2025-04-25

Abstract

Abstract

Objective To investigate the impact of nutritional risk-based intervention on the quality of life and survival prognosis of patients with the locally advanced pancreatic cancer and undergoing the chemotherapy. Methods A total of 118 patients with the pancreatic cancer and admitted to the Department of Hepatobiliary and Minimally Invasive Surgery, Lincang People's Hospital from April 2021 to April 2024 were selected and randomly divided into the nutritional intervention group and the control group, with 59 patients in each group. All patients received the palliative chemotherapy, and the control group received the routine dietary guidance, while the intervention group received the nutritional intervention based on the nutritional risk score. The nutritional status, quality of life score, and survival prognosis of the two groups were compared. Results The NRS2002 score of the intervention group and the control group gradually increased from the first to the sixth chemotherapy, and the NRS2002 score of the intervention group was lower than that of the control group at the 4th, 5th, and 6th chemotherapy （P < 0.05）. The incidence of malnutrition in the intervention group was lower than that of the control group at the 1st, 2nd, and 3rd chemotherapy （11.9%, 30.9%, and 32.2%, respectively）, but there was no significant difference （P > 0.05）; The incidence of malnutrition in the intervention group was significantly lower than that of the control group at the 4th, 5th, and 6th chemotherapy （32.2%, 45.8%, and 52.5%, respectively）, while the incidence of malnutrition in the control group was 59.3%, 69.5%, and 88.5%, respectively （P < 0.05）; The quality of life score of the intervention group in all dimensions was significantly higher than that of the control group after the treatment （P < 0.05）. After the nutritional intervention, the median OS time and median PFS time of the patients were significantly improved （P < 0.05）. Conclusion Nutritional intervention can reduce the nutritional risk during the chemotherapy for locally advanced pancreatic cancer patients and improve their quality of life.
- Pancreatic cancer,
- Nutritional intervention,
- Locally advanced,
- Quality of life

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References(30)

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