Predictive Ability of Platelet Reactivity，ROCK1 Combined with Electrocardiogram Findings for Slow Blood Flow/No Reflow in Elderly Patients after PCI

Baoquan WU; Xiaoxia LIU

doi:10.12259/j.issn.2095-610X.S20250420

Volume 46 Issue 4

Apr. 2025

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Baoquan WU, Xiaoxia LIU. Predictive Ability of Platelet Reactivity，ROCK1 Combined with Electrocardiogram Findings for Slow Blood Flow/No Reflow in Elderly Patients after PCI[J]. Journal of Kunming Medical University, 2025, 46(4): 150-156. doi: 10.12259/j.issn.2095-610X.S20250420

Citation:

Baoquan WU, Xiaoxia LIU. Predictive Ability of Platelet Reactivity，ROCK1 Combined with Electrocardiogram Findings for Slow Blood Flow/No Reflow in Elderly Patients after PCI[J]. Journal of Kunming Medical University, 2025, 46(4): 150-156. doi: 10.12259/j.issn.2095-610X.S20250420

Citation:

Baoquan WU, Xiaoxia LIU. Predictive Ability of Platelet Reactivity，ROCK1 Combined with Electrocardiogram Findings for Slow Blood Flow/No Reflow in Elderly Patients after PCI[J]. Journal of Kunming Medical University, 2025, 46(4): 150-156. doi: 10.12259/j.issn.2095-610X.S20250420

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Predictive Ability of Platelet Reactivity，ROCK1 Combined with Electrocardiogram Findings for Slow Blood Flow/No Reflow in Elderly Patients after PCI

doi: 10.12259/j.issn.2095-610X.S20250420

Baoquan WU¹,
Xiaoxia LIU^{2
,
,}

1.
Department of Cardiology
2.
Department of Geriatrics，The First Hospital of Zhangjiakou，Zhangjiakou Hebei 075000，China

Received Date: 2024-09-06
Available Online: 2025-04-07
Publish Date: 2025-04-25

Abstract

Abstract

Objective To investigate the predictive value of platelet reactivity, RhoC and Rho kinase 1 （ROCK1） combined with the electrocardiogram performance for slow flow/no reflow （SF/NRF） after the percutaneous coronary intervention （PCI） in elderly patients. Methods A retrospective analysis was conducted on the clinical data of 263 elderly PCI patients admitted to our hospital from January 2021 to July 2024. According to TIMI flow classification after PCI, they were divided into SF/NRF group （grade 0-II of TIMI flow classification, 42 cases） and the control group （grade III of TIMI flow classification, 221 cases）. The baseline data and platelet reactivity, ROCK1, and ECG performance were compared between the two groups and the factors influencing SF/NRF after PCI in the elderly were analyzed. The value of joint predictors, each original covariate to predict SF/NRF after PCI in the elderly was evaluated. Results The proportion of patients with HPR, ROCK1, QTc, and T-wave inversion in SF/NRF group was higher than that in the control group （P < 0.05）; increased HPR, ROCK1, QTc, and T-wave inversion were independent risk factors for SF/NRF after PCI in the elderly （P < 0.05）; the AUC of the combined predictors for predicting SF/NRF after PCI in the elderly was significantly higher than that of the original covariates HPR （X₁）, ROCK1 （X₂, QTc （X₃）, and T-wave inversion （X₄）（Z = 5.112, 3.688, 4.368, 5.697, P < 0.05）. Conclusion The increase of HPR, ROCK1, QTc and T wave inversion are independent risk factors for SF/NRF after PCI in the elderly. The combined detection of these indicators has certain predictive value for the occurrence of SF/NRF after PCI in the elderly.
- Elderly,
- Percutaneous coronary intervention therapy,
- Slow blood flow/no reflow,
- Platelet reactivity,
- RhoC and Rho kinase 1,
- Predictive

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References(27)

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