Impact of PINK1/Parkin-Mediated Mitophagy in the Development of Neurodegenerative Diseases

Kongjia WU; Shuqian DOU; Yuan WANG; Qi WANG; Pan DU; Wenjun LIU

doi:10.12259/j.issn.2095-610X.S20250601

Volume 46 Issue 6

Jun. 2025

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Kongjia WU, Shuqian DOU, Yuan WANG, Qi WANG, Pan DU, Wenjun LIU. Impact of PINK1/Parkin-Mediated Mitophagy in the Development of Neurodegenerative Diseases[J]. Journal of Kunming Medical University, 2025, 46(6): 1-8. doi: 10.12259/j.issn.2095-610X.S20250601

Citation:

Kongjia WU, Shuqian DOU, Yuan WANG, Qi WANG, Pan DU, Wenjun LIU. Impact of PINK1/Parkin-Mediated Mitophagy in the Development of Neurodegenerative Diseases[J]. Journal of Kunming Medical University, 2025, 46(6): 1-8. doi: 10.12259/j.issn.2095-610X.S20250601

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Impact of PINK1/Parkin-Mediated Mitophagy in the Development of Neurodegenerative Diseases

doi: 10.12259/j.issn.2095-610X.S20250601

Department of Burns，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

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Corresponding author: 刘文军，男，博士，教授，昆明医科大学第二附属医院烧伤科主任，博士生导师，长期致力于危重烧伤救治、复杂创面修复、瘢痕的临床治疗及基础研究工作。中华医学会烧伤外科分会常委，中国医师协会烧伤科医师分会常委，云南省医学会烧伤与创面修复外科分会主任委员，美国北卡Wake Forest医学院公派访问学者，云南省万人计划“名医”，中华烧伤与创面修复杂志编委，先后主持国家自然科学基金3项，省部级课题3项，发表国内外文章20余篇，获省级科技进步二等奖2项。
Received Date: 2025-03-05
Publish Date: 2025-06-25

Abstract

Abstract

Mitochondria not only serve as the central hub for cellular energy metabolism, but also participate in crucial physiological processes such as signal transduction and activity regulation. Abnormal mitochondrial quantity, imbalance in mtDNA copy number, accumulation of genetic mutations, and aberrant activation of autophagic pathways can lead to mitochondrial dysfunction or even organelle disorders, while activating mechanisms of cellular damage and death, consequently contributing to the pathogenesis of various diseases. As a highly selective form of autophagy, mitophagy plays a pivotal regulatory role in organelle quality control and homeostasis maintenance. This article focuses on the classic PINK1/Parkin pathway-mediated mitophagy as an entry point, summarizing recent research advances regarding the role of mitophagy in neurodegenerative diseases, aiming to provide novel insights for developing targeted mitophagy regulation strategies to improve prevention and treatment approaches for neurodegenerative disorders.
- Mitophagy,
- Oxidative stress,
- Parkinson's,
- Alzheimer's disease

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References(46)

References

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