Correlation Analysis of Serum IL-37 and NLRP3 Levels with Disease Severity and Their Joint Predictive Value for Prognosis in COPD Patients with SIRS

Zhaoyue ZHANG; Fengyuan LYU; Qianqian SHU; Ying YANG

doi:10.12259/j.issn.2095-610X.S20250614

Volume 46 Issue 6

Jun. 2025

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Article Navigation > Journal of Kunming Medical University > 2025 > 46(6): 111-118

Zhaoyue ZHANG, Fengyuan LYU, Qianqian SHU, Ying YANG. Correlation Analysis of Serum IL-37 and NLRP3 Levels with Disease Severity and Their Joint Predictive Value for Prognosis in COPD Patients with SIRS[J]. Journal of Kunming Medical University, 2025, 46(6): 111-118. doi: 10.12259/j.issn.2095-610X.S20250614

Citation:

Zhaoyue ZHANG, Fengyuan LYU, Qianqian SHU, Ying YANG. Correlation Analysis of Serum IL-37 and NLRP3 Levels with Disease Severity and Their Joint Predictive Value for Prognosis in COPD Patients with SIRS[J]. Journal of Kunming Medical University, 2025, 46(6): 111-118. doi: 10.12259/j.issn.2095-610X.S20250614

Citation:

Zhaoyue ZHANG, Fengyuan LYU, Qianqian SHU, Ying YANG. Correlation Analysis of Serum IL-37 and NLRP3 Levels with Disease Severity and Their Joint Predictive Value for Prognosis in COPD Patients with SIRS[J]. Journal of Kunming Medical University, 2025, 46(6): 111-118. doi: 10.12259/j.issn.2095-610X.S20250614

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Correlation Analysis of Serum IL-37 and NLRP3 Levels with Disease Severity and Their Joint Predictive Value for Prognosis in COPD Patients with SIRS

doi: 10.12259/j.issn.2095-610X.S20250614

Department of Respiratory Medicine，The First People’s Hospital of Zigong City，Zigong Sichuan 643000，China

Received Date: 2024-11-28
Publish Date: 2025-06-25

Abstract

Abstract

Objective To analyze the correlation between serum interleukin-37 （IL-37） and nucleotide-binding oligomerization domain-like receptor protein 3 （NLRP3） with disease severity in chronic obstructive pulmonary disease （COPD） patients with systemic inflammatory response syndrome （SIRS）, and evaluate their combined predictive value for prognosis. Methods A total of 150 patients with COPD and SIRS in Zigong First People's Hospital from January 2023 to March 2024 were selected as the study group, and 150 patients with COPD were selected as the control group. The groups were compared for general data and serum IL-37 and NLRP3 levels upon admission. The serum IL-37 and NLRP3 levels of patients with different disease severities in the study group were compared to analyze their correlation with disease severity. 28-day prognosis of both groups was compared, and the serum IL-37 and NLRP3 levels of patients with poor and good prognosis in the study group were analyzed. Univariate and multivariate Logistic regression was used to assess factors influencing poor prognosis in COPD patients with SIRS. The predictive value of serum IL-37 and NLRP3 for poor prognosis was evaluated, and their interactive effects on patient outcomes were analyzed. Results The study group's serum IL-37 and NLRP3 levels were higher upon admission compared to the control group（P < 0.05）; serum IL-37 and NLRP3 levels in extremely severe patients were higher than those in severe, moderate, and mild patients, with severe patients higher than moderate and mild patients, and moderate patients higher than mild patients （P < 0.05）; serum IL-37 and NLRP3 levels at admission were positively correlated with the disease severity of COPD patients with SIRS （P < 0.05）; patients with poor prognosis had higher serum IL-37 and NLRP3 levels upon admission compared to those with good prognosis （P < 0.05）; serum IL-37 and NLRP3 levels at admission were independent risk factors for poor prognosis in COPD patients with SIRS （P < 0.05）; the AUC for predicting poor prognosis using serum IL-37 and NLRP3 alone were 0.805 and 0.834, respectively, while the combined AUC was 0.920, which was higher than the individual AUCs （P < 0.05）; interaction analysis showed that high serum IL-37 and NLRP3 levels exhibited a positive super-multiplicative interaction in the prognosis of COPD patients with SIRS （P < 0.05）. Conclusion Serum IL-37 and NLRP3 levels in COPD patients with SIRS were positively correlated with disease severity, and the combined serum IL-37 and NLRP3 showed high predictive efficacy for patient prognosis.

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References(29)

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