The Role of Mitochondrial Function in Adipose Tissue in Obesity

Ying QIAN; Jizhuo YANG; Juan HUANG; Kedi YUAN; Junyi LIU; Yuemei FENG; Jianzhong YIN

doi:10.12259/j.issn.2095-610X.S20250701

Volume 46 Issue 7

Jul. 2025

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Ying QIAN, Jizhuo YANG, Juan HUANG, Kedi YUAN, Junyi LIU, Yuemei FENG, Jianzhong YIN. The Role of Mitochondrial Function in Adipose Tissue in Obesity[J]. Journal of Kunming Medical University, 2025, 46(7): 1-9. doi: 10.12259/j.issn.2095-610X.S20250701

Citation:

Ying QIAN, Jizhuo YANG, Juan HUANG, Kedi YUAN, Junyi LIU, Yuemei FENG, Jianzhong YIN. The Role of Mitochondrial Function in Adipose Tissue in Obesity[J]. Journal of Kunming Medical University, 2025, 46(7): 1-9. doi: 10.12259/j.issn.2095-610X.S20250701

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The Role of Mitochondrial Function in Adipose Tissue in Obesity

doi: 10.12259/j.issn.2095-610X.S20250701

Ying QIAN^{1, 2
,},
Jizhuo YANG^{1, 2},
Juan HUANG³,
Kedi YUAN^{1, 2},
Junyi LIU^{1, 2},
Yuemei FENG^{1, 2},
Jianzhong YIN^{1, 2, 4
,
,}

1.
Yunnan Provincial Key Laboratory of Public Health and Biosafety，Kunming Yunnan 650500
2.
Schoolof Public Health，Kunming Medical University，Kunming Yunnan 650500
3.
Department of Ultrasound Medicine，the First Affiliated Hospital，Kunming Medical University，Kunming Yunnan 650032
4.
Key Laboratory of Nutrition and Food Safety of Yunnan Provincial Education Department，Kunming Yunnan 650500，China

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Corresponding author: 殷建忠，二级教授，博士生导师，国务院政府特殊津贴专家，云岭教学名师，国家级一流本科课程负责人，教育部首届高校健康教育教指委委员，健康云南发展智库首席专家，云南省高校营养与食品安全重点实验室主任、精准营养与公共健康博士生导师团队带头人，省级专家工作站项目负责人。研究领域：营养流行病学。主持国家重点研发计划课题1项、国家自然科学基金 4 项、云南省科技厅基础研究专项计划重点项目1项。获云南省哲学社会科学优秀成果一等奖1项、科技进步三等奖 4 项、卫生科技成果二等奖1项及三等奖3项。代表性成果发表于The Lancet Regional Health-Western Pacific、JHEP Reports、eLife等期刊，入选ESI高水平论文2篇，在The BMJ发表文章简评（Rapid Response）15篇，论文摘要入选Cell Symposium、The Lancet Summit国际学术会议。主持完成教育部公共卫生与预防医学学术学位研究生课程建设项目，获云南省高等教育教学成果奖二等奖1项。
Received Date: 2025-06-04
Publish Date: 2025-07-21

Abstract

Abstract

Obesity has become a major global public health issue, and the situation in China is also becoming increasingly severe. Adipose tissue is categorized into white adipose tissue （WAT） and brown adipose tissue （BAT）, which regulates metabolic homeostasis by secreting various adipokines. Mitochondria, as the core organelles of energy metabolism, its dysfunction are closely related to obesity. In the state of obesity, mitochondrial dynamics imbalance, oxidative stress, and metabolic dysfunction can all lead to energy metabolism disorders and adipose tissue dysfunction. Moreover, mitochondrial dysfunction not only affects adipose tissue but also extends to multiple organs such as muscles and livers, thereby exacerbating obesity and related metabolic diseases. In recent years, although numerous therapeutic strategies targeting mitochondrial dysfunction have been actively explored, their clinical translation faces challenges. This review explores the association between mitochondrial dysfunction in adipose tissue and obesity, analyses its mechanism and existing treatment strategies, aiming to provide a new perspective for the diagnosis and treatment of obesity.
- Obesity,
- Adipose tissue,
- Mitochondrial dysfunction,
- Metabolic disorders

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References(57)

References

[1]	GBD 2021 Adult BMI Collaborators. Global,regional,and national prevalence of adult overweight and obesity,1990-2021,with forecasts to 2050: A forecasting study for the Global Burden of Disease Study 2021[J]. Lancet,2025,405(10481):813-838. doi: 10.1016/S0140-6736(25)00355-1
[2]	Pan X F,Wang L,Pan A. Epidemiology and determinants of obesity in China[J]. Lancet Diabetes Endocrinol,2021,9(6):373-392. doi: 10.1016/S2213-8587(21)00045-0
[3]	Forner F,Kumar C,Luber C A,et al. Proteome differences between brown and white fat mitochondria reveal specialized metabolic functions[J]. Cell Metab,2009,10(4):324-335. doi: 10.1016/j.cmet.2009.08.014
[4]	Scheja L,Heeren J. The endocrine function of adipose tissues in health and cardiometabolic disease[J]. Nat Rev Endocrinol,2019,15(9):507-524. doi: 10.1038/s41574-019-0230-6
[5]	Kajimura S,Spiegelman B M,Seale P. Brown and beige fat: Physiological roles beyond heat generation[J]. Cell Metab,2015,22(4):546-559. doi: 10.1016/j.cmet.2015.09.007
[6]	Crewe C,An Y A,Scherer P E. The ominous triad of adipose tissue dysfunction: Inflammation,fibrosis,and impaired angiogenesis[J]. J Clin Invest,2017,127(1):74-82. doi: 10.1172/JCI88883
[7]	Choe S S,Huh J Y,Hwang I J,et al. Adipose tissue remodeling: Its role in energy metabolism and metabolic disorders[J]. Front Endocrinol (Lausanne),2016,7:30.
[8]	Nunnari J,Suomalainen A. Mitochondria: In sickness and in health[J]. Cell,2012,148(6):1145-1159. doi: 10.1016/j.cell.2012.02.035
[9]	Kusminski C M,Scherer P E. Mitochondrial dysfunction in white adipose tissue[J]. Trends Endocrinol Metab,2012,23(9):435-443. doi: 10.1016/j.tem.2012.06.004
[10]	Fedorenko A,Lishko P V,Kirichok Y. Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria[J]. Cell,2012,151(2):400-413. doi: 10.1016/j.cell.2012.09.010
[11]	Wang R,Li X N. Different adipose tissue depots and metabolic syndrome in human[J]. Sheng Li Xue Bao,2017,69(3):357-365.
[12]	Cohen P,Spiegelman B M. Brown and beige fat: Molecular parts of a thermogenic machine[J]. Diabetes,2015,64(7):2346-2351. doi: 10.2337/db15-0318
[13]	Zong Y,Li H,Liao P,et al. Mitochondrial dysfunction: Mechanisms and advances in therapy[J]. Signal Transduct Target Ther,2024,9(1):124. doi: 10.1038/s41392-024-01839-8
[14]	Cogliati S,Enriquez J A,Scorrano L. Mitochondrial cristae: Where beauty meets functionality[J]. Trends Biochem Sci,2016,41(3):261-273. doi: 10.1016/j.tibs.2016.01.001
[15]	Baker N,Patel J,Khacho M. Linking mitochondrial dynamics,cristae remodeling and super complex formation: How mitochondrial structure can regulate bioenergetics[J]. Mitochondrion,2019,49:259-268. doi: 10.1016/j.mito.2019.06.003
[16]	Van Laar V S,Berman S B. The interplay of neuronal mitochondrial dynamics and bioenergetics: Implications for Parkinson's disease[J]. Neurobiol Dis,2013,51:43-55. doi: 10.1016/j.nbd.2012.05.015
[17]	Masenga S K,Kabwe L S,Chakulya M,et al. Mechanisms of oxidative stress in metabolic syndrome[J]. Int J Mol Sci,2023,24(9):7898. doi: 10.3390/ijms24097898
[18]	De Fano M,Bartolini D,Tortoioli C,et al. Adipose tissue plasticity in response to pathophysiological cues: A connecting link between obesity and its associated comorbidities[J]. Int J Mol Sci,2022,23(10):5511. doi: 10.3390/ijms23105511
[19]	Boutant M,Kulkarni S S,Joffraud M,et al. Mfn2 is critical for brown adipose tissue thermogenic function[J]. EMBO J,2017,36(11):1543-1558. doi: 10.15252/embj.201694914
[20]	Ding J,Zhang Z,Li S,et al. Mdivi-1 alleviates cardiac fibrosis post myocardial infarction at infarcted border zone,possibly via inhibition of Drp1-Activated mitochondrial fission and oxidative stress[J]. Arch Biochem Biophys,2022,718:109147. doi: 10.1016/j.abb.2022.109147
[21]	Pafili K,Kahl S,Mastrototaro L,et al. Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease[J]. J Hepatol,2022,77(6):1504-1514. doi: 10.1016/j.jhep.2022.08.010
[22]	Eirin A,Thaler R,Glasstetter L M,et al. Obesity-driven mitochondrial dysfunction in human adipose tissue-derived mesenchymal stem/stromal cells involves epigenetic changes[J]. Cell Death Dis,2024,15(6):387. doi: 10.1038/s41419-024-06774-8
[23]	Lee Y H,Kuk M U,So M K,et al. Targeting mitochondrial oxidative stress as a strategy to treat aging and age-related diseases[J]. Antioxidants (Basel),2023,12(4):934. doi: 10.3390/antiox12040934
[24]	Anderson E J,Lustig M E,Boyle K E,et al. Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans[J]. J Clin Invest,2009,119(3):573-581. doi: 10.1172/JCI37048
[25]	D'Autréaux B,Toledano M B. ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis[J]. Nat Rev Mol Cell Biol,2007,8(10):813-824. doi: 10.1038/nrm2256
[26]	Brand M D,Goncalves R L S,Orr A L,et al. Suppressors of superoxide-H₂O₂ production at site I(Q) of mitochondrial complex I protect against stem cell hyperplasia and ischemia-reperfusion injury[J]. Cell Metab,2016,24(4):582-592. doi: 10.1016/j.cmet.2016.08.012
[27]	Chouchani E T,Pell V R,James A M,et al. A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury[J]. Cell Metab,2016,23(2):254-263. doi: 10.1016/j.cmet.2015.12.009
[28]	Liu Q,Zhang D,Hu D,et al. The role of mitochondria in NLRP3 inflammasome activation[J]. Mol Immunol,2018,103:115-124. doi: 10.1016/j.molimm.2018.09.010
[29]	Houstis N,Rosen E D,Lander E S. Reactive oxygen species have a causal role in multiple forms of insulin resistance[J]. Nature,2006,440(7086):944-948. doi: 10.1038/nature04634
[30]	Li H S,Zhou Y N,Li L,et al. HIF-1α protects against oxidative stress by directly targeting mitochondria[J]. Redox Biol,2019,25:101109. doi: 10.1016/j.redox.2019.101109
[31]	Cannon B,Nedergaard J. Brown adipose tissue: Function and physiological significance[J]. Physiol Rev,2004,84(1):277-359. doi: 10.1152/physrev.00015.2003
[32]	Koves T R,Ussher J R,Noland R C,et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance[J]. Cell Metab,2008,7(1):45-56. doi: 10.1016/j.cmet.2007.10.013
[33]	Petersen K F,Befroy D,Dufour S,et al. Mitochondrial dysfunction in the elderly: Possible role in insulin resistance[J]. Science,2003,300(5622):1140-1142. doi: 10.1126/science.1082889
[34]	Bueno M,Calyeca J,Rojas M,et al. Mitochondria dysfunction and metabolic reprogramming as drivers of idiopathic pulmonary fibrosis[J]. Redox Biol,2020,33:101509. doi: 10.1016/j.redox.2020.101509
[35]	Bennett C F,Latorre-Muro P,Puigserver P. Mechanisms of mitochondrial respiratory adaptation[J]. Nat Rev Mol Cell Biol,2022,23(12):817-835. doi: 10.1038/s41580-022-00506-6
[36]	Heikkinen A,Esser V F C,Lee S H T,et al. Twin pair analysis uncovers links between DNA methylation,mitochondrial DNA quantity and obesity[J]. Nat Commun,2025,16(1):4374. doi: 10.1038/s41467-025-59576-7
[37]	Rossetti G,Ermer J A,Stentenbach M,et al. A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance[J]. Sci Adv,2021,7(39):eabi7514. doi: 10.1126/sciadv.abi7514
[38]	Kist M,Vucic D. Cell death pathways: Intricate connections and disease implications[J]. EMBO J,2021,40(5):e106700. doi: 10.15252/embj.2020106700
[39]	Guerra I M S,Ferreira H B,Melo T,et al. Mitochondrial fatty acid β-oxidation disorders: From disease to lipidomic studies-a critical review[J]. Int J Mol Sci,2022,23(22):13933. doi: 10.3390/ijms232213933
[40]	Chen B,Lyssiotis C A,Shah Y M. Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis[J]. Mol Cell,2025,85(8):1487-1508. doi: 10.1016/j.molcel.2025.03.003
[41]	Li X,Zhao X,Qin Z,et al. Regulation of calcium homeostasis in endoplasmic reticulum-mitochondria crosstalk: Implications for skeletal muscle atrophy[J]. Cell Commun Signal,2025,23(1):17. doi: 10.1186/s12964-024-02014-w
[42]	Walkon L L,Strubbe-Rivera J O,Bazil J N. Calcium overload and mitochondrial metabolism[J]. Biomolecules,2022,12(12):1891. doi: 10.3390/biom12121891
[43]	Mahmoud A M. An overview of epigenetics in obesity: The role of lifestyle and therapeutic interventions[J]. Int J Mol Sci,2022,23(3):1341. doi: 10.3390/ijms23031341
[44]	Sun Y,Ge X,Li X,et al. High-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction[J]. Cell Death Dis,2020,11(10):914. doi: 10.1038/s41419-020-03122-4
[45]	Lolescu B M,Furdui-Lința A V,Ilie C A,et al. Adipose tissue as target of environmental toxicants: Focus on mitochondrial dysfunction and oxidative inflammation in metabolic dysfunction-associated steatotic liver disease[J]. Mol Cell Biochem,2025,480(5):2863-2879. doi: 10.1007/s11010-024-05165-z
[46]	Bajpeyi S,Covington J D,Taylor E M,et al. Skeletal muscle PGC1α-1 nucleosome position and -260 nt DNA methylation determine exercise response and prevent ectopic lipid accumulation in Men[J]. Endocrinology,2017,158(7):2190-2199. doi: 10.1210/en.2017-00051
[47]	Rossman M J,Santos-Parker J R,Steward C A C,et al. Chronic supplementation with a mitochondrial antioxidant (MitoQ) improves vascular function in healthy older adults[J]. Hypertension,2018,71(6):1056-1063. doi: 10.1161/HYPERTENSIONAHA.117.10787
[48]	Xu X,Pang Y,Fan X. Mitochondria in oxidative stress,inflammation and aging: From mechanisms to therapeutic advances[J]. Signal Transduct Target Ther,2025,10(1):190. doi: 10.1038/s41392-025-02253-4
[49]	Jiang S,Nong T,Yu T,et al. Long term exposure to multiple environmental stressors induces mitochondrial dynamics imbalance in testis: Insights from metabolomics and transcriptomics[J]. Environ Int,2025,198:109390. doi: 10.1016/j.envint.2025.109390
[50]	Chen L,Hong M,Luan C,et al. Efficient mitochondrial A-to-G base editors for the generation of mitochondrial disease models[J]. Nat Biotechnol,2025. doi: 10.1038/s41587-025-02685-x. doi: 10.1038/s41587-025-02685-x
[51]	Silva-Pinheiro P,Minczuk M. The potential of mitochondrial genome engineering[J]. Nat Rev Genet,2022,23(4):199-214. doi: 10.1038/s41576-021-00432-x
[52]	Lin X,Li L,Li S,et al. Targeting the opening of mitochondrial permeability transition pores potentiates nanoparticle drug delivery and mitigates cancer metastasis[J]. Adv Sci,2021,8(4):2002834. doi: 10.1002/advs.202002834
[53]	Joaquim M,Altin S,Bulimaga M B,et al. Mitofusin 2 displays fusion-independent roles in proteostasis surveillance[J]. Nat Commun,2025,16(1):1501. doi: 10.1038/s41467-025-56673-5
[54]	Zhang Y,Zhang H,Zhao F,et al. Mitochondrial-targeted and ROS-responsive nanocarrier via nose-to-brain pathway for ischemic stroke treatment[J]. Acta Pharm Sin B,2023,13(12):5107-5120. doi: 10.1016/j.apsb.2023.06.011
[55]	Wang S,Wang Z,Zang Z,et al. A mitochondrion-targeting piezoelectric nanosystem for the treatment of erectile dysfunction via autophagy regulation[J]. Adv Mater,2025,37(5):e2413287. doi: 10.1002/adma.202413287
[56]	Zhang K,Du Y,Yang S,et al. Irisin suppressed the progression of TBI via modulating AMPK/MerTK/autophagy and SYK/ROS/inflammatory signaling[J]. Sci Rep,2025,15(1):15583. doi: 10.1038/s41598-025-00066-7
[57]	de Vos W M,Tilg H,Van Hul M,et al. Gut microbiome and health: Mechanistic insights[J]. Gut,2022,71(5):1020-1032. doi: 10.1136/gutjnl-2021-326789

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