Relationship between the Platelet Autophagy-related Factor Expression and Peritoneal Metastasis of Gastric Cancer

Xiaoxiao FAN; Xuan ZENG; Pingping ZHOU; Xi LIU; Feifei ZHU; Yanji LUO; Yi WU

doi:10.12259/j.issn.2095-610X.S20250715

Volume 46 Issue 7

Jul. 2025

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Article Navigation > Journal of Kunming Medical University > 2025 > 46(7): 125-130

Xiaoxiao FAN, Xuan ZENG, Pingping ZHOU, Xi LIU, Feifei ZHU, Yanji LUO, Yi WU. Relationship between the Platelet Autophagy-related Factor Expression and Peritoneal Metastasis of Gastric Cancer[J]. Journal of Kunming Medical University, 2025, 46(7): 125-130. doi: 10.12259/j.issn.2095-610X.S20250715

Citation:

Xiaoxiao FAN, Xuan ZENG, Pingping ZHOU, Xi LIU, Feifei ZHU, Yanji LUO, Yi WU. Relationship between the Platelet Autophagy-related Factor Expression and Peritoneal Metastasis of Gastric Cancer[J]. Journal of Kunming Medical University, 2025, 46(7): 125-130. doi: 10.12259/j.issn.2095-610X.S20250715

Citation:

Xiaoxiao FAN, Xuan ZENG, Pingping ZHOU, Xi LIU, Feifei ZHU, Yanji LUO, Yi WU. Relationship between the Platelet Autophagy-related Factor Expression and Peritoneal Metastasis of Gastric Cancer[J]. Journal of Kunming Medical University, 2025, 46(7): 125-130. doi: 10.12259/j.issn.2095-610X.S20250715

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Relationship between the Platelet Autophagy-related Factor Expression and Peritoneal Metastasis of Gastric Cancer

doi: 10.12259/j.issn.2095-610X.S20250715

1.
Department of Medical Laboratory，Changsha Traditional Chinese Medicine Hospital/Affiliated Hospital of Hunan University of Traditional Chinese Medicine，Changsha Hunan 410000
2.
Department of Laboratory Medicine，Hunan Chest Hospital，Changsha Hunan 410000
3.
Department of Laboratory Medicine，Hunan Provincial People’s Hospital/The First Affiliated Hospital of Hunan Normal University，Changsha Hunan 410000，China

Received Date: 2025-04-11
Publish Date: 2025-07-21

Abstract

Abstract

Objective To investigate the relationship between the expression of platelet autophagy related factors and peritoneal metastasis of gastric cancer. Methods The data of 360 patients with gastric cancer who underwent surgery in Hunan Provincial People’ s Hospital from January 2021 to May 2023 were reviewed. Patients were divided into non-peritoneal metastasis group (n = 322) and peritoneal metastasis group (n = 38) according to whether peritoneal metastasis occurred or not. The following information was collected: patient's personal information （i.e. age, sex, body mass index） and tumor characteristics （i.e. location, size, pathological type, histopathological differentiation, lymphatic infiltration）. Platelets were collected from all subjects, and the levels of autophagy-associated protein 7（ATG7）, benzalkonium chloride 1（BECN1）, microtubule-associated protein 1 light chain 3（LC3） and sequestosome 1（p62） were measured by enzyme-linked immunosorbent assay （ELISA）. Results Among the 360 patients included, peritoneal metastasis was detected in 38 cases. Compared with the non-peritoneal metastasis group, the peritoneal metastasis group exhibited decreased BMI（P < 0.05）, while the tumor size, non-ulcerative tumor, number of lymph node metastasis, infiltration depth, number of cases of lymphatic invasion, platelet count, platelet LC3-II level, platelet ATG7 level and CEA level were increased （P < 0.05）. Multivariate logistic regression analysis showed that BMI （OR = 1.094）, lymphatic invasion （OR = 2.658）, and LC3-II （OR = 3.793） and ATG7（OR = 2.010） were independent influencing factors for peritoneal metastasis in patients with gastric cancer （P < 0.05）. LC3-II > 2.59ng/ml had the highest ability to predict peritoneal metastasis in patients with gastric cancer （AUC = 0.932）, followed by ATG7（AUC = 0.916）. Conclusions Elevated levels of platelet LC3-Ⅱ and ATG7 are independently related to peritoneal metastasis in patients with gastric cancer, and can be used to predict the occurrence of peritoneal metastasis, which is helpful to guide individualized treatment.
- Gastric cancer,
- Platelets,
- Autophagy,
- Peritoneal metastasis

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