Efficacy of CO<sub>2</sub> Fractional Laser Combined with Interferon in Treating Persistent High-Risk HPV Infection of the Cervix

Xinghui CHEN; Lisha MA; Yuan WANG; Lichi ZHANG; Aiju CHEN; Hongxian LI; Junjing HE

doi:10.12259/j.issn.2095-610X.S20250717

Volume 46 Issue 7

Jul. 2025

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Article Navigation > Journal of Kunming Medical University > 2025 > 46(7): 139-145

Xinghui CHEN, Lisha MA, Yuan WANG, Lichi ZHANG, Aiju CHEN, Hongxian LI, Junjing HE. Efficacy of CO2 Fractional Laser Combined with Interferon in Treating Persistent High-Risk HPV Infection of the Cervix[J]. Journal of Kunming Medical University, 2025, 46(7): 139-145. doi: 10.12259/j.issn.2095-610X.S20250717

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Xinghui CHEN, Lisha MA, Yuan WANG, Lichi ZHANG, Aiju CHEN, Hongxian LI, Junjing HE. Efficacy of CO₂ Fractional Laser Combined with Interferon in Treating Persistent High-Risk HPV Infection of the Cervix[J]. Journal of Kunming Medical University, 2025, 46(7): 139-145. doi: 10.12259/j.issn.2095-610X.S20250717

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Efficacy of CO₂ Fractional Laser Combined with Interferon in Treating Persistent High-Risk HPV Infection of the Cervix

doi: 10.12259/j.issn.2095-610X.S20250717

Health Management Center，Maternal and Child Health Hospital of Kunming，Kunming Yunnan 650031，China

Received Date: 2025-04-06
Publish Date: 2025-07-21

Abstract

Abstract

Objective To investigate the clinical efficacy of intravaginal CO₂ fractional laser combined with interferon in treating persistent high-risk HPV infection of the cervix and its impact on vaginal microecology. Methods A total of 211 patients with persistent high-risk HPV infection of the cervix who visited Kunming Maternal and Child Health Care Hospital from June 2022 to July 2024 were selected and randomly divided into a follow-up （blank control） group （n = 70）, an interferon treatment group （n = 70）, and a combined treatment group （n = 71）. The follow-up group received regular follow-ups. The interferon treatment group was treated with recombinant human interferon α-2b, and the combined treatment group received a combination of CO₂ matrix laser and interferon treatment. The total effective rate, levels of inflammatory factors, and vaginal microecological recovery were compared among the three groups at 3 and 6 months after treatment. Results Overall efficacy: The overall efficacy rates of the combined treatment group at 3 months and 6 months were 73.24% and 81.69%, respectively, significantly higher than those of the interferon group （47.14% and 60.00%） and the blank control group （11.43% and 18.57%）（all P < 0.001）. Inflammatory factors: Post-treatment levels of IL-1 and TNF-α in the combined treatment group were significantly lower than those in the other two groups （P < 0.001）. Vaginal microbiota: The combined treatment group had a significantly higher rate of normal PH （84.51%） and normal lactobacillus levels（92.96%） compared to the other two groups （P < 0.001）. Conclusion CO₂ lattice laser combined with interferon can effectively eliminate HPV, improve inflammation and vaginal microenvironment, and demonstrates superior efficacy to monotherapy, with good safety.
- CO₂ lattice laser,
- Interferon,
- Persistent high-risk HPV infection,
- Vaginal microecology

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References(31)

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