Correlation between Epidermal Growth Factor Gene Polymorphisms and Non-small Cell Lung Cancer

Yueting YAO; Shuai LI; Yang CAO; Mu LIN; Zhengguang LUO; Xiaobo CHEN; Qianli MA

doi:10.12259/j.issn.2095-610X.S20250910

Volume 46 Issue 9

Sep. 2025

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Yueting YAO, Shuai LI, Yang CAO, Mu LIN, Zhengguang LUO, Xiaobo CHEN, Qianli MA. Correlation between Epidermal Growth Factor Gene Polymorphisms and Non-small Cell Lung Cancer[J]. Journal of Kunming Medical University, 2025, 46(9): 89-97. doi: 10.12259/j.issn.2095-610X.S20250910

Citation:

Yueting YAO, Shuai LI, Yang CAO, Mu LIN, Zhengguang LUO, Xiaobo CHEN, Qianli MA. Correlation between Epidermal Growth Factor Gene Polymorphisms and Non-small Cell Lung Cancer[J]. Journal of Kunming Medical University, 2025, 46(9): 89-97. doi: 10.12259/j.issn.2095-610X.S20250910

Citation:

Yueting YAO, Shuai LI, Yang CAO, Mu LIN, Zhengguang LUO, Xiaobo CHEN, Qianli MA. Correlation between Epidermal Growth Factor Gene Polymorphisms and Non-small Cell Lung Cancer[J]. Journal of Kunming Medical University, 2025, 46(9): 89-97. doi: 10.12259/j.issn.2095-610X.S20250910

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Correlation between Epidermal Growth Factor Gene Polymorphisms and Non-small Cell Lung Cancer

doi: 10.12259/j.issn.2095-610X.S20250910

1.
Department of Medical Laboratory，The Third People’s Hospital of Yunnan Province，Kunming Yunnan 650011
2.
Department of Thoracic Surgery，The Third Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118
3.
Department of Laboratory Medicine，The Second People’s Hospital of Baoshan，Baoshan Yunnan 678000
4.
Department of Thoracic Surgery，The First Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2024-12-16
Available Online: 2025-10-28
Publish Date: 2025-09-25

Abstract

Abstract

Objective To investigate the correlation between single nucleotide polymorphisms （SNPs） of the EGF gene, including rs11569017 （A>T）, rs2237051 （A>G）, rs3733625 （C>T）, and rs4444903 （A>G）, and the risk of non-small cell lung cancer （NSCLC） in a Han population of Yunnan. Methods A total of 439 patients with NSCLC and 520 healthy controls were recruited in Yunnan Province between January 2022 and December 2023. Genotyping of four SNP loci in the EGF gene was performed using TaqMan probes, followed by analysis of allele, genotype, genetic model, and haplotype distribution frequencies between NSCLC and control groups. Stratified analyses were further conducted based on NSCLC pathological types and clinical stages. Results The rs2237051 locus showed significant differences in allele （P = 0.011） and genotype （P = 0.042） frequencies between the squamous cell carcinoma （SCC） group and the control group. The frequency of the A allele was lower in the SCC group than in the control group （OR = 0.71, 95%CI 0.54～1.85）, but there was no difference after Bonferroni correction （P > 0.0125）. Under the log-additive model, the rs2237051-2G/G + A/G genotype was associated with an increased risk of SCC （P = 0.01; OR = 1.42, 95%CI 1.08～1.86）. However, the association lost statistical significance after Bonferroni correction （P > 0.0125）. The haplotype rs11569017-rs2237051-rs3733625-rs4444903 has no difference between the two groups （P > 0.0125）. The stratified analysis revealed no significant associations between the genetic loci and different disease stages （P > 0.0125）. Conclusion In the Yunnan Han population, the individuals carrying the rs2237051-A allele of the EGF gene have a significantly lower risk of squamous lung cancer, but further functional experiments are needed to verify the protective mechanism.
- Non-small cell lung cancer,
- Epidermal growth factor,
- Single nucleotide polymorphism,
- Correlation

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References(26)

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