Clinical Applications and Potential Mechanisms of Repetitive Transcranial Magnetic Stimulation in Prolonged Disorders of Consciousness

Jianlin PU; Jing FU; Zhong LI; Qiuyue MAO; Hongpeng LIU; Yadong LIU; Xuesong GAI

doi:10.12259/j.issn.2095-610X.S20251001

Volume 46 Issue 10

Oct. 2025

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Jianlin PU, Jing FU, Zhong LI, Qiuyue MAO, Hongpeng LIU, Yadong LIU, Xuesong GAI. Clinical Applications and Potential Mechanisms of Repetitive Transcranial Magnetic Stimulation in Prolonged Disorders of Consciousness[J]. Journal of Kunming Medical University, 2025, 46(10): 1-11. doi: 10.12259/j.issn.2095-610X.S20251001

Citation:

Jianlin PU, Jing FU, Zhong LI, Qiuyue MAO, Hongpeng LIU, Yadong LIU, Xuesong GAI. Clinical Applications and Potential Mechanisms of Repetitive Transcranial Magnetic Stimulation in Prolonged Disorders of Consciousness[J]. Journal of Kunming Medical University, 2025, 46(10): 1-11. doi: 10.12259/j.issn.2095-610X.S20251001

Citation:

Jianlin PU, Jing FU, Zhong LI, Qiuyue MAO, Hongpeng LIU, Yadong LIU, Xuesong GAI. Clinical Applications and Potential Mechanisms of Repetitive Transcranial Magnetic Stimulation in Prolonged Disorders of Consciousness[J]. Journal of Kunming Medical University, 2025, 46(10): 1-11. doi: 10.12259/j.issn.2095-610X.S20251001

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Clinical Applications and Potential Mechanisms of Repetitive Transcranial Magnetic Stimulation in Prolonged Disorders of Consciousness

doi: 10.12259/j.issn.2095-610X.S20251001

1.
The Second Clinical Medical College of Yunnan University of Traditional Chinese Medicine，Kunming Yunnan 650500
2.
Department of Rehabilitation Medicine，The First People’s Hospital of Yunnan Province，Kunming Yunnan 650032，China

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Corresponding author: 盖雪松，云南省第一人民医院康复医学科主任，主任医师，神经外科专业硕士，硕士研究生导师，兴滇名医。长期从事神经疾病康复、骨科与运动康复的临床康复工作，开展干细胞联合富血小板血浆治疗膝骨关节炎、神经调控促醒及帕金森与阿尔茨海默病治疗、脊髓磁电刺激结合中药外治治疗压力性尿失禁等临床工作及研究。担任中华康复医学会阿尔茨海默病及认知功能障碍康复专委会全国常委、中华康复医学会手功能康复专委会全国委员、中华康复医学会社区专委会全国委员、中华康复医学会脑功能检测与康复专委会全国委员、云南省康复医学会常务理事、云南省康复医学会社区康复专委会副主任委员、云南省康复医学会脑血管病康复专委会副主任委员、云南省康复医学会中西医结合康复专委会副主任委员。以第一作者及通讯作者发表SCI等论文十余篇，专著1部，主持国家自然科学基金、云南省生物医药重大专项及省级科研基金项目6项，获批新型实用专利2项，参与获得省级科技进步一等奖。
Received Date: 2025-03-11
Available Online: 2025-10-20
Publish Date: 2025-10-28

Abstract

Abstract

Prolonged disorders of consciousness （pDoC） are complex and prolonged conditions that severely impact patient prognosis and remain a clinical treatment challenge. In recent years, neural regulation-based awakening therapies have been widely applied in the assessment and treatment of pDoC patients. Repetitive transcranial magnetic stimulation （rTMS） technology can regulate neural activity and improve patients' consciousness states, demonstrating positive awakening effects for pDoC patients. However, the optimal stimulation parameters and awakening mechanisms of rTMS remain unclear. This article reviews the pathological mechanisms of pDoC, clinical applications of rTMS at different targeting sites and stimulation frequencies, and focuses on exploring how rTMS promotes consciousness recovery through neural mechanisms such as altering neural pathways, reshaping brain networks, promoting synaptic plasticity and neurotransmitter release, regulating neurotrophic factor expression, and modulating cerebral hemodynamics. Based on artificial intelligence, the article also prospects the future clinical research applications of rTMS.
- Repetitive transcranial magnetic stimulation,
- Prolonged disorders of consciousness,
- Concionsness recovery,
- Neuromodulation,
- Action mechanism

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References(77)

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[8]	Yue XU, Chan WANG, Shucheng LIN, Huijie ZHANG, Yi TAN, Shuwei ZHANG, Xiaofeng ZENG, Zhen LI. Advances in the Mechanism of Hepatotoxic Effects Induced by α-amanitin. Journal of Kunming Medical University, 2022, 43(12): 153-158. doi: 10.12259/j.issn.2095-610X.S20221228
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[12]	Zhen-dong YANG, Yun-yan LAN, Yu ZHENG, Yu-ran FENG, Mei ZHU. Changes of c-Fos Protein and Structural Plasticity in Nucleus Accumbens of Mice after Ultrasound Stimulation. Journal of Kunming Medical University, 2021, 42(6): 45-49. doi: 10.12259/j.issn.2095-610X.S20210645
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