Volume 46 Issue 10
Oct.  2025
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Qinfen GAO, Shegang LI, Jun LIU, Yan TANG, Fajun YANG, Yaowu CHEN, Wei ZHANG. Epidemiological Characteristics of Venomous Snakebite in Yunnan Province[J]. Journal of Kunming Medical University, 2025, 46(10): 12-22. doi: 10.12259/j.issn.2095-610X.S20251002
Citation: Qinfen GAO, Shegang LI, Jun LIU, Yan TANG, Fajun YANG, Yaowu CHEN, Wei ZHANG. Epidemiological Characteristics of Venomous Snakebite in Yunnan Province[J]. Journal of Kunming Medical University, 2025, 46(10): 12-22. doi: 10.12259/j.issn.2095-610X.S20251002

Epidemiological Characteristics of Venomous Snakebite in Yunnan Province

doi: 10.12259/j.issn.2095-610X.S20251002
  • Received Date: 2025-08-26
    Available Online: 2025-10-02
  • Publish Date: 2025-10-28
  •   Objective  To explore the epidemiological characteristics and treatment outcomes of venomous snake bites in Yunnan Province from 2023 to 2024.   Methods  A retrospective analysis was performed on 1, 727 snakebite cases collected from 16 administrative regions in Yunnan Province between January 2023 and December 2024, focusing on the following indicators: (1) demographic characteristics (age and gender distribution); (2) characteristics of injury events (location, time distribution, and affected body parts); (3) composition of venomous snake species; (4) clinical features and treatment protocols; (5) efficacy evaluation indicators (time for local symptom relief, duration of hospital stay, and follow-up results).   Results  High-incidence areas for snake bites in Yunnan Province included Wenshan (308/1727), Kunming (285/1727), Qujing (270/1727), Lincang (139/1727), Baoshan (120/1727), and Dali (105/1727), with incidents primarily occurring from June to September. The most frequently encountered venomous snake species were Ovophis and Trimeresurus, known for their hemotoxic venom. Bite victims were mainly young adults. Clinical manifestations primarily included pain and swelling, with bites mainly occurring on limbs and in mountainous or forested areas. Anti-venom treatment concentrated on anti-ancistrodon acutus serum. Swelling generally subsided within 2 (2, 3) days, with an average hospital stay of 4 (3, 5) days. 96.46% of patients receiving standardized treatment fully recovered, with a follow-up disability rate of 0.35%.   Conclusion  The incidents of venomous snake bites in Yunnan Province have significant regional and seasonal concentration, with Wenshan, Kunming, Qujing and other areas being high-risk areas. The peak period of incidents is from June to September in summer, and the main types of snakes causing injuries are those containing blood toxins; The victim group is mainly young people, and bites often occur in the limbs, with typical symptoms of pain and swelling; The main treatment is anti snake serum; Snake bite patients who receive formal diagnosis and treatment have a higher recovery rate and a lower follow-up disability rate, but there is still a need to raise public awareness of standardized diagnosis and treatment for snake bites.
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  • [1]
    Alcoba G, Sharma S K, Bolon I, et al. Snakebite epidemiology in humans and domestic animals across the Terai region in Nepal: A multicluster random survey[J]. Lancet Glob Health, 2022, 10(3): e398-e408. doi: 10.1016/S2214-109X(22)00028-6
    [2]
    Afroz A, Siddiquea B N, Chowdhury H A, et al. Snakebite envenoming: A systematic review and meta-analysis of global morbidity and mortality[J]. PLoS Negl Trop Dis, 2024, 18(4): e0012080. doi: 10.1371/journal.pntd.0012080
    [3]
    Ahmed S M, Ahmed M, Nadeem A, et al. Emergency treatment of a snake bite: Pearls from literature[J]. Emerg Trauma Shock, 2008, 1(2): 97-105. doi: 10.4103/0974-2700.43190
    [4]
    Kasturiratne A, Wickremasinghe A R, De Silva N, et al. The global burden of snakebite: A literature analysis and modelling based on regional estimates of envenoming and deaths[J]. PLoS Med, 2008, 5(11): e218. doi: 10.1371/journal.pmed.0050218
    [5]
    Liang M, Liang P, Luo W, et al. Epidemiological analysis of 952 venomous snake bite in Wuzhou City of Guangxi Zhuang Autonomous Region[J]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, 2022, 34(1): 85-90.
    [6]
    Minghui R, Malecela M N, Cooke E, et al. WHO's Snakebite envenoming strategy for prevention and control[J]. Lancet Glob Health, 2019, 7(7): e837-e838. doi: 10.1016/S2214-109X(19)30225-6
    [7]
    李稳, 方庆, 李兴华, 等. 湖北地区毒蛇咬伤流行病学调查及随访分析[J]. 临床急诊杂志, 2023, 24(3): 131-136.
    [8]
    王剀, 吕植桐, 王健, 等. 云南省爬行动物名录和地理区划更新[J]. 生物多样性, 2022, 30(4): 123-153.
    [9]
    Zhong G H, Chen W D, Liu Q, et al. Valid or not? Yunnan mountain snake Plagiopholis unipostocularis (Serpentes: Colubridae: Pseudoxenodontinae)[J]. Zootaxa, 2015, 4020(2): 390-396.
    [10]
    Alirol E, Sharma S K, Bawaskar H S, et al. Snake bite in South Asia: A review[J]. PLoS Negl Trop Dis, 2010, 4(1): e603. doi: 10.1371/journal.pntd.0000603
    [11]
    中华医学会急诊医学分会, 国家急诊质控中心, 中国医师协会急诊医师分会, 等. 中国蛇伤救治指南[J]. 中华急诊医学杂志, 2024, 33(7): 891-906.
    [12]
    李其斌, 吕传柱, 梁子敬, 等. 2018年中国蛇伤救治专家共识[J]. 中国急救医学, 2018, 38(12): 1026-1034.
    [13]
    Hua Z. Biogeographical divergence of the flora of Yunnan, southwestern China initiated by the uplift of Himalaya and extrusion of Indochina block[J]. PLoS One, 2012, 7(9): e45601. doi: 10.1371/journal.pone.0045601
    [14]
    Lai R, Yan S, Wang S, et al. The Chinese guideline for management of snakebites[J]. World J Emerg Med, 2024, 15(5): 333-355. doi: 10.5847/wjem.j.1920-8642.2024.076
    [15]
    Hou S B, Yuan Z Y, Wei P F, et al. Molecular phylogeny and morphological comparisons of the genus Hebius Thompson, 1913 (Reptilia: Squamata: Colubridae) uncover a new taxon from Yunnan Province, China, and support revalidation of Hebius septemlineatus (Schmidt, 1925)[J]. Zool Res, 2021, 42(5): 620-625. doi: 10.24272/j.issn.2095-8137.2021.093
    [16]
    丁利, 史静耸, 王馨. 蝮蛇中国毒蛇的第一旺族[J]. 森林与人类, 2025, 5(2): 38-47.
    [17]
    Li K E, Yu M, Wu Y Y, et al. A new species of the genus Achalinus (Squamata: Xenodermatidae) from southeastern Yunnan Province, China[J]. Zootaxa, 2020, 4860(1): 4860-4866.
    [18]
    高琴芬, 张玮, 马静怡, 等. 竹叶青蛇咬伤所致的功能障碍及诊疗策略进展[J]. 中国急救医学, 2025, 45(4): 359-364.
    [19]
    Iliyasu G, Tiamiyu A B, Daiyab F M, et al. Effect of distance and delay in access to care on outcome of snakebite in rural north-eastern Nigeria[J]. Rural Remote Health, 2015, 15(4): 3496.
    [20]
    Dehghani R, Rabani D, Panjeh Shahi M, et al. Incidence of snake bites in Kashan, Iran during an eight year period (2004-2011)[J]. Arch Trauma Res, 2012, 1(2): 67-71. doi: 10.5812/atr.6445
    [21]
    Kumar K S, Narayanan S, Udayabhaskaran V, et al. Clinical and epidemiologic profile and predictors of outcome of poisonous snake bites - an analysis of 1, 500 cases from a tertiary care center in Malabar, North Kerala, India[J]. Int J Gen Med, 2018, 11: 209-216. doi: 10.2147/IJGM.S136153
    [22]
    陈伟, 俞点, 彭张玲. 福建武夷山毒蛇咬伤流行病学特征分析[J]. 蛇志, 2025, 37(2): 148-151.
    [23]
    刘安平, 薛植瑞, 陈江华, 等. 贵州遵义地区毒蛇咬伤流行病学分析及预防救治体会[J]. 创伤外科杂志, 2025, 27(6): 430-436.
    [24]
    李学红, 高继伟, 任魁, 等. 云南省普洱市802例毒蛇咬伤流行病学分析[J]. 蛇志, 2024, 36(2): 121-125.
    [25]
    王长久. 季德胜蛇药治疗毒蛇咬伤的效果观察[J]. 当代医药论丛, 2019, 17(6): 173-174.
    [26]
    Seifert S A, Armitage J O, Sanchez E E. Snake envenomation[J]. Reply N Engl J Med, 2022, 386(11): 1100.
    [27]
    Hifumi T, Yamamoto A, Morokuma K, et al. Clinical efficacy of antivenom and cepharanthine for the treatment of Mamushi (Gloydius blomhoffii) bites in tertiary care centers in Japan[J]. Jpn J Infect Dis, 2013, 66(1): 26-31. doi: 10.7883/yoken.66.26
    [28]
    Silva A, Hifumi T, Sakai A, et al. Rhabdophis tigrinus is not a pit viper but its bites result in venom-induced consumptive coagulopathy similar to many viper bites[J]. J Intensive Care, 2014, 2(1): 43. doi: 10.1186/s40560-014-0043-6
    [29]
    Tan C H, Palasuberniam P, Tan K Y. Snake venom proteomics, immunoreactivity and toxicity neutralization studies for the asiatic mountain pit vipers, Ovophis convictus, Ovophis tonkinensis, and Hime habu, Ovophis okinavensis[J]. Toxins (Basel), 2021, 13(8): 6-13.
    [30]
    Maduwage K, Isbister G K. Current treatment for venom-induced consumption coagulopathy resulting from snakebite[J]. PLoS Negl Trop Dis, 2014, 8(10): e3220. doi: 10.1371/journal.pntd.0003220
    [31]
    Margono F, Outwater A H, Lowery Wilson M, et al. Snakebite treatment in Tanzania: Identifying gaps in community practices and hospital resources[J]. Int J Environ Res Public Health, 2022, 19(8): 19084701.
    [32]
    Isbister G K. Antivenom availability, delays and use in Australia[J]. Toxicon X, 2023, 17(8): 100145.
    [33]
    Jeon Y J, Kim J W, Park S, et al. Risk factor, monitoring, and treatment for snakebite induced coagulopathy: A multicenter retrospective study[J]. Acute Crit Care, 2019, 34(4): 269-275. doi: 10.4266/acc.2019.00591
    [34]
    Navaeifar M R, Zakariaei Z, Ghadiri A, et al. Compartment syndrome following snakebite in a boy: A case report and literature review[J]. Int J Surg Case Rep, 2023, 10(5): 108050.
    [35]
    Canas C A. Is the acute compartment syndrome diagnosed in snake bites true?: A review[J]. Medicine (Baltimore), 2024, 103(40): e40008.
    [36]
    Luo Y, Zhang J, Zhai C, et al. Clinical study on the application of covered vacuum sealing drainage technology to the bite of venomous snakes of trimeresurus stejnegeri in Guangxi[J]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, 2020, 32(10): 1241-1246.
    [37]
    林起庆, 何斌, 李峥. 小切口负压治疗对竹叶青蛇咬伤后肢体肿胀和凝血功能的影响[J]. 蛇志, 2018, 30(3): 396-398.
    [38]
    Faisal T, Tan K Y, Tan N H, et al. Proteomics, toxicity and antivenom neutralization of Sri Lankan and Indian Russell's viper (Daboia russelii) venoms[J]. J Venom Anim Toxins Incl Trop Dis, 2021, 27(30): e20200177.
    [39]
    Abraham S V, Hakkeem B, Mathew D, et al. Hematotoxic snakebite victim with trauma: The role of guided transfusion, rotational thromboelastometry, and tranexamic acid[J]. Wilderness Environ Med, 2020, 31(4): 470-481. doi: 10.1016/j.wem.2020.08.003
    [40]
    Holla S K, Rao H A, Shenoy D, et al. The role of fresh frozen plasma in reducing the volume of anti-snake venom in snakebite envenomation[J]. Trop Doct, 2018, 48(2): 89-93. doi: 10.1177/0049475518756083
    [41]
    Qian X H, Ma L. Fibrinolytic enzyme from Agkistrodon halys brevicaudus (Korean mamushi) snake venom[J]. Toxicon, 1991, 29(11): 1381-1386. doi: 10.1016/0041-0101(91)90125-B
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