Clinical Relationship between Glycolysis，Iron Metabolism Indicators and Cardiovascular Status in Patients with Chronic Obstructive Pulmonary Disease-Coronary Artery Disease

Bin FANG; Yunpeng HU; Na HAO

doi:10.12259/j.issn.2095-610X.S20251010

Volume 46 Issue 10

Oct. 2025

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Bin FANG, Yunpeng HU, Na HAO. Clinical Relationship between Glycolysis，Iron Metabolism Indicators and Cardiovascular Status in Patients with Chronic Obstructive Pulmonary Disease-Coronary Artery Disease[J]. Journal of Kunming Medical University, 2025, 46(10): 85-90. doi: 10.12259/j.issn.2095-610X.S20251010

Citation:

Bin FANG, Yunpeng HU, Na HAO. Clinical Relationship between Glycolysis，Iron Metabolism Indicators and Cardiovascular Status in Patients with Chronic Obstructive Pulmonary Disease-Coronary Artery Disease[J]. Journal of Kunming Medical University, 2025, 46(10): 85-90. doi: 10.12259/j.issn.2095-610X.S20251010

Citation:

Bin FANG, Yunpeng HU, Na HAO. Clinical Relationship between Glycolysis，Iron Metabolism Indicators and Cardiovascular Status in Patients with Chronic Obstructive Pulmonary Disease-Coronary Artery Disease[J]. Journal of Kunming Medical University, 2025, 46(10): 85-90. doi: 10.12259/j.issn.2095-610X.S20251010

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Clinical Relationship between Glycolysis，Iron Metabolism Indicators and Cardiovascular Status in Patients with Chronic Obstructive Pulmonary Disease-Coronary Artery Disease

doi: 10.12259/j.issn.2095-610X.S20251010

1.
Department of Respiratory Medicine
2.
Physical Examination Department，Zhuozhou Hospital，Zhuozhou Hebei 072750，China

Received Date: 2025-02-05
Publish Date: 2025-10-28

Abstract

Abstract

Objective To evaluate the predictive value of pyruvate kinase M2（PKM2） and transferrin saturation （TSAT） for major adverse cardiovascular events （MACE） in chronic obstructive pulmonary disease （COPD）- coronary artery disease （CAD） patients after percutaneous coronary intervention （PCI）, and to analyze the relationship between these indicators and patients' cardiac function status. Methods The study cohort included 94 COPD-CAD patients diagnosed in Zhuozhou Hospital from January 2020 to May 2022. Left ventricular end-diastolic volume （LVEDV）, left ventricular end-systolic volume （LVSV）, left ventricular ejection fraction （LVEF）, mitral valve inflow velocity （E） and early diastolic mitral annular velocity （e'） were assessed by echocardiography. Plasma PKM2 and TSAT levels were analyzed using enzyme-linked immunosorbent assay kit. All patients were followed up for 2 years. The study end point was defined as MACE. Results During follow-up, 22 patients （23.4%） experienced MACE. Compared with the non-MACE group, the MACE group showed increased peripheral blood PKM2 levels （P < 0.05） and decreased TSAT levels （P < 0.05）. PKM2 was positively correlated with left ventricular end-systolic volume and E/e' （r = 0.204 and 0.209, both P < 0.05）, and negatively correlated with ejection fraction and TSAT （r = -0.430 and -0.641, both P < 0.001）. TSAT was negatively correlated with left ventricular end-diastolic volume, left ventricular end-systolic volume and E/e' （r = -0.309, -0.470, -0.411, all P < 0.001）, and positively correlated with ejection fraction （r = 0.470, P < 0.001）. PKM2 （Hr = 9.375, 95%CI = 4.145～21.203） and TSAT （Hr = 0.753, 95%CI = 0.645～0.878） were independent influencing factors of MACE events in COPD-CAD patients （P < 0.05）. The AUC of PKM2 and TSAT in predicting MACE events were 0.835 （95%CI = 0.729～0.940） and 0.878 （95%CI = 0.811～0.946）, respectively, with specificity of 72.7% and 90.9%, and sensitivity of 87.5% and 80.6%, respectively. Conclusion In patients with COPD-CAD treated by PCI, the changes of PKM2 and TSAT levels are independently related to MACE events, and are helpful to predict the occurrence of MACE events.
- Pyruvate kinase M2,
- Transferrin saturation,
- Chronic obstructive pulmonary disease,
- Coronary artery disease,
- Cardiovascular events,
- Percutaneous coronary intervention

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References(20)

References

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