Effects of Early Statin Therapy on Collateral Circulation，Responsible Vessels，and TXB2/PGF1α in Large Artery Occlusive Stroke

Fei YANG; Jing LI; Yanjun CHEN; Xuemei WU; Guoyong REN

doi:10.12259/j.issn.2095-610X.S20251016

Volume 46 Issue 10

Oct. 2025

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Article Navigation > Journal of Kunming Medical University > 2025 > 46(10): 129-136

Fei YANG, Jing LI, Yanjun CHEN, Xuemei WU, Guoyong REN. Effects of Early Statin Therapy on Collateral Circulation，Responsible Vessels，and TXB2/PGF1α in Large Artery Occlusive Stroke[J]. Journal of Kunming Medical University, 2025, 46(10): 129-136. doi: 10.12259/j.issn.2095-610X.S20251016

Citation:

Fei YANG, Jing LI, Yanjun CHEN, Xuemei WU, Guoyong REN. Effects of Early Statin Therapy on Collateral Circulation，Responsible Vessels，and TXB2/PGF1α in Large Artery Occlusive Stroke[J]. Journal of Kunming Medical University, 2025, 46(10): 129-136. doi: 10.12259/j.issn.2095-610X.S20251016

Citation:

Fei YANG, Jing LI, Yanjun CHEN, Xuemei WU, Guoyong REN. Effects of Early Statin Therapy on Collateral Circulation，Responsible Vessels，and TXB2/PGF1α in Large Artery Occlusive Stroke[J]. Journal of Kunming Medical University, 2025, 46(10): 129-136. doi: 10.12259/j.issn.2095-610X.S20251016

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Effects of Early Statin Therapy on Collateral Circulation，Responsible Vessels，and TXB2/PGF1α in Large Artery Occlusive Stroke

doi: 10.12259/j.issn.2095-610X.S20251016

Department of Neurology，Taiyuan Iron and Steel （Group） Co.，Ltd. General Hospital，Taiyuan Shanxi 030003，China

Received Date: 2025-02-24
Publish Date: 2025-10-28

Abstract

Abstract

Objective To investigate the effects of early statin therapy on collateral circulation, responsible vessel improvement, and thromboxane B2 （TXB2）/prostaglandin F1 （PGF1α） in acute ischemic stroke with large vessel occlusion （AIS-LVO）. Methods From May 2021 to May 2023, 105 AIS-LVO patients treated with statins within 3 days of admission were selected as the statin group from the Neurology Department of Taiyuan Iron and Steel （Group） General Hospital. Concurrently, 105 early AIS-LVO patients not treated with statins were selected as the non-statin group. The study compared symptom scores [National Institutes of Health Stroke Scale （NIHSS）, modified Rankin Scale （mRS）, Swallowing Standard Assessment （SSA）, and Functional Oral Intake Scale （FOIS） scores], responsible vessel improvement, TXB2/PGF1α levels, and endothelial function indicators [basic fibroblast growth factor （bFGF） and circulating endothelial cells （CECs）]. Results After 1 and 2 weeks , the statin group showed lower NIHSS, mRS, and SSA scores, and higher FOIS scores compared to the non-statin group （P < 0.02）. The statin group demonstrated higher rates of responsible vessel velocity increase, collateral circulation compensation, and superior CTA collateral circulation grading （P < 0.05）. At 1 and 2 weeks, the statin group had lower TXB2 and TXB2/PGF1α levels, and higher PGF1α levels compared to the non-statin group （P < 0.02）. The statin group showed lower bFGF levels and higher CECs levels （P < 0.02）. After 3 months, the statin group had a higher proportion of mRS scores of 0～2 （P < 0.05）. Conclusion Early statin therapy in AIS-LVO patients can improve responsible vessel blood flow and endothelial function, regulate TXB2/PGF1α levels, promote collateral circulation compensation, and enhance swallowing and neurological function recovery.
- Acute ischemic stroke with large vessel occlusion,
- Statins,
- Thromboxane B2,
- Prostaglandin F1 alpha,
- Collateral circulation

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References(35)

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