Synergistic Mechanisms and Applications of Phage-antibiotic Combination Therapy

Xuelin LI; Xiaoyan YANG; Zehua HAN; Yuliang CHEN; Xingyuan XU; Chunyan ZHANG; Yingying XIANG

doi:10.12259/j.issn.2095-610X.S20251201

Volume 46 Issue 12

Dec. 2025

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Xuelin LI, Xiaoyan YANG, Zehua HAN, Yuliang CHEN, Xingyuan XU, Chunyan ZHANG, Yingying XIANG. Synergistic Mechanisms and Applications of Phage-antibiotic Combination Therapy[J]. Journal of Kunming Medical University, 2025, 46(12): 1-8. doi: 10.12259/j.issn.2095-610X.S20251201

Citation:

Xuelin LI, Xiaoyan YANG, Zehua HAN, Yuliang CHEN, Xingyuan XU, Chunyan ZHANG, Yingying XIANG. Synergistic Mechanisms and Applications of Phage-antibiotic Combination Therapy[J]. Journal of Kunming Medical University, 2025, 46(12): 1-8. doi: 10.12259/j.issn.2095-610X.S20251201

Citation:

Xuelin LI, Xiaoyan YANG, Zehua HAN, Yuliang CHEN, Xingyuan XU, Chunyan ZHANG, Yingying XIANG. Synergistic Mechanisms and Applications of Phage-antibiotic Combination Therapy[J]. Journal of Kunming Medical University, 2025, 46(12): 1-8. doi: 10.12259/j.issn.2095-610X.S20251201

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Synergistic Mechanisms and Applications of Phage-antibiotic Combination Therapy

doi: 10.12259/j.issn.2095-610X.S20251201

1.
Department of Stomatology
2.
Department of Dermatology，Yan’an Hospital Affiliated to Kunming Medical University，Kunming Yunnan 650031
3.
Department of Stomatology，Xundian Hui and Yi Autonomous County People’s Hospital，Kunming Yunnan 655200，China

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Corresponding author: 向盈盈，博士，主任医师，硕士研究生导师，副教授。云南省高层次卫生健康技术人才医学学科带头人，昆明市春城计划青年拔尖人才，昆明市卫生科技人才培养百工程带头人，担任云南省口腔医学会生物医学专委会副主任委员，云南省口腔医学会修复专委会常务委员，云南女医师协会口腔分会常务委员、秘书，中华口腔医学会全科口腔医学专委会青年委员，中华口腔医学会口腔修复学专委会青年委员。长期从事3D数字化精准口腔种植技术、CAD/CAM制作全瓷冠、嵌体及各类牙体缺损、牙列缺损、牙列缺失等疑难复杂病例临床诊疗工作及噬菌体疗法在口腔临床医学中的应用研究。主持国家自然科学基金1项，省级项目3项，获云南省科技进步奖三等奖1项，云南省卫生科技成果奖三等奖4项，获授权发明专利6项、实用新型专利24项。建立向盈盈专家工作站2个，开展新技术8项。以第一作者及通讯作者发表学术论文26篇，其中SCI论文11篇，代表性成果发表于Canadian Journal of Microbiology、Dyes and Pigments、Journal of Aoac International等期刊，在组织工程TOP期刊Applied Microbiology and Biotechnology发表高水平论文1篇，在Microbial Pathogenesis期刊发表系列文章3篇。
Received Date: 2025-06-30
Available Online: 2025-12-06
Publish Date: 2025-12-25

Abstract

Abstract

The overuse of antibiotics has led to a rapid increase of antibiotic-resistant bacteria, making bacterial infections difficult to control effectively and posing a serious threat to human health. As antibiotic resistance problems become increasingly severe and the development of new antibiotics lags, finding more effective treatment strategies has become an urgent need in global public health. Bacteriophages, as a potential therapeutic option, have attracted increasing attention in recent years; however, bacteriophages have limitations such as a narrow host range and lysogeny. Synergistic effects between bacteriophages and antibiotics enhance bacteriophage lytic activity, reduce antibiotic dosage, significantly lower the risk of resistance development, and demonstrate superior antimicrobial efficacy. This review summarizes the mechanisms and research progress of bacteriophage-antibiotic synergy, aiming to further advance research and clinical application of combined bacteriophage-antibiotic therapy and provide new solutions to address the problem of antibiotic resistance.
- Bacteriophage,
- Antibiotic,
- Combination therapy,
- Resistance,
- Synergistic effects

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References(44)

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