Research Progress of Mesenchymal Stem Cells in the Treatment of Allergic Rhinitis via the Treg-ILC2 Axis

Rui CHEN; Shouming CAO; Haiying WU; Haosu HUANG; Xiaoying ZHOU; Weiyue HAN; Zongcheng JIANG

doi:10.12259/j.issn.2095-610X.S20260301

Volume 47 Issue 3

Mar. 2026

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Rui CHEN, Shouming CAO, Haiying WU, Haosu HUANG, Xiaoying ZHOU, Weiyue HAN, Zongcheng JIANG. Research Progress of Mesenchymal Stem Cells in the Treatment of Allergic Rhinitis via the Treg-ILC2 Axis[J]. Journal of Kunming Medical University, 2026, 47(3): 1-11. doi: 10.12259/j.issn.2095-610X.S20260301

Citation:

Rui CHEN, Shouming CAO, Haiying WU, Haosu HUANG, Xiaoying ZHOU, Weiyue HAN, Zongcheng JIANG. Research Progress of Mesenchymal Stem Cells in the Treatment of Allergic Rhinitis via the Treg-ILC2 Axis[J]. Journal of Kunming Medical University, 2026, 47(3): 1-11. doi: 10.12259/j.issn.2095-610X.S20260301

Citation:

Rui CHEN, Shouming CAO, Haiying WU, Haosu HUANG, Xiaoying ZHOU, Weiyue HAN, Zongcheng JIANG. Research Progress of Mesenchymal Stem Cells in the Treatment of Allergic Rhinitis via the Treg-ILC2 Axis[J]. Journal of Kunming Medical University, 2026, 47(3): 1-11. doi: 10.12259/j.issn.2095-610X.S20260301

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Research Progress of Mesenchymal Stem Cells in the Treatment of Allergic Rhinitis via the Treg-ILC2 Axis

doi: 10.12259/j.issn.2095-610X.S20260301

Department of Otorhinolaryngology，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

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Corresponding author: 吴海莺，医学博士，三级主任医师，博士生导师。云南省医学学科带头人；加拿大多伦多大学访问学者；中国医药教育协会眩晕分会常委；云南女医师协会耳鼻喉分会主任委员；云南省康复医学会言语与听力康复专委会主任委员；云南省医学会耳鼻咽喉头颈外科学分会委员；鼻科学组组长；省级专家工作站项目负责人。研究领域：变应性鼻病，鼻颅底外科。主持国家自然科学基金、省、厅级科研项目共4项。以第一/通讯作者在American Journal of Rhinology & Allergy，World Allergy Organ J，Int Immunopharmacol发表多篇代表作。参编人民卫生出版社及其它出版社专著5部。
Received Date: 2025-12-09
Available Online: 2026-03-08
Publish Date: 2026-03-31

Abstract

Abstract

Allergic rhinitis （AR） is a chronic airway disorder predominantly driven by type 2 inflammation, in which T helper （Th） cells, innate lymphoid cells （ILCs）, and their characteristic type 2 cytokines serve as the core pathogenic mechanisms. Recent evidence highlights that the immune imbalance between regulatory T cells （Tregs） and group 2 innate lymphoid cells （ILC2s）, termed as the Treg-ILC2 axis, has been recognized as a critical regulatory hub in AR pathogenesis. Mesenchymal stem cells （MSCs）, characterized by potent immunomodulatory properties, can induce iTreg differentiation and suppress ILC2 hyperactivation through the secretion of soluble factors （e.g., TGF-β, IL-10） and direct cell-to-cell contact mediated by the ICOS-ICOSL （inducible T-cell costimulator-inducible T-cell costimulator ligand ） interaction. By reviewing the cross-talk mechanisms between Tregs and ILC2s, this article focuses on the research progress of MSCs in restoring immune homeostasis in AR via the Treg-ILC2 axis, aiming to provide theoretical foundations and novel insights for precise immune-targeted therapies for AR.
- Allergic rhinitis,
- Immune-targeted therapy,
- Group 2 innate lymphoid cells,
- Regulatory T cells,
- Mesenchymal stem cells,
- Animal model

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References(84)

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