Research Progress on Non-coding RNA in the Pathogenesis and Clinical Application of Preeclampsia

Yali LIU; Yao SHEN; Xingqi WU; Jinman ZHANG

doi:10.12259/j.issn.2095-610X.S20260317

Volume 47 Issue 3

Mar. 2026

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Article Navigation > Journal of Kunming Medical University > 2026 > 47(3): 151-162

Yali LIU, Yao SHEN, Xingqi WU, Jinman ZHANG. Research Progress on Non-coding RNA in the Pathogenesis and Clinical Application of Preeclampsia[J]. Journal of Kunming Medical University, 2026, 47(3): 151-162. doi: 10.12259/j.issn.2095-610X.S20260317

Citation:

Yali LIU, Yao SHEN, Xingqi WU, Jinman ZHANG. Research Progress on Non-coding RNA in the Pathogenesis and Clinical Application of Preeclampsia[J]. Journal of Kunming Medical University, 2026, 47(3): 151-162. doi: 10.12259/j.issn.2095-610X.S20260317

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Research Progress on Non-coding RNA in the Pathogenesis and Clinical Application of Preeclampsia

doi: 10.12259/j.issn.2095-610X.S20260317

Yali LIU^{1, 2},
Yao SHEN^{1, 2},
Xingqi WU^{1, 2},
Jinman ZHANG^{1, 2
,
,}

1.
Department of Medical Genetics，Yunnan Provincial First People's Hospital/National Key Laboratory of Western China for Eugenics and Birth Defects Prevention and Control，Ministry of Health and Family Planning，Kunming Yunnan 650034
2.
School of Medicine，Kunming University of Science and Technology，Kunming Yunnan 650500，China

Received Date: 2025-12-18
Available Online: 2026-03-08
Publish Date: 2026-03-31

Abstract

Abstract

Preeclampsia （PE） is a pregnancy complication with an unclear etiology, posing a serious threat to maternal and fetal health. It currently lacks effective methods for early prediction and prevention. This review systematically summarizes the latest research advances concerning three categories of non-coding RNAs （ncRNAs）: microRNAs （miRNAs）, long non-coding RNAs （lncRNAs）, and circular RNAs （circRNAs）. It focuses on elucidating the specific mechanisms by which these ncRNAs drive the pathogenesis of PE through complex regulatory networks. These networks impact multiple critical pathological processes, including trophoblast function, placental vascular remodeling, maternal-fetal interface immune inflammation, and oxidative stress. Additionally, the review highlights the significant clinical application potential of ncRNAs as novel biomarkers and therapeutic targets. It also explores the major challenges in current clinical translation and future research directions, aiming to provide theoretical foundations and innovative insights for the precise prevention, diagnosis, and management of PE.
- Preeclampsia,
- Non-coding RNA,
- microRNA,
- Long non-coding RNA,
- Circular RNA

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References(81)

References

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