Predictive Value of INETs combined with Neutrophil Indicators for Thromboembolic Complications in Patients under ECMO Assistance

Xin LIU; Changyu LI; Na LI; Jing QIANG; Rong JI; Wenhui MENG; Zesheng ZHANG

doi:10.12259/j.issn.2095-610X.S202607

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Article Navigation > Journal of Kunming Medical University > 2026 > Accepted Manuscript

Xin LIU, Changyu LI, Na LI, Jing QIANG, Rong JI, Wenhui MENG, Zesheng ZHANG. Predictive Value of INETs combined with Neutrophil Indicators for Thromboembolic Complications in Patients under ECMO Assistance[J]. Journal of Kunming Medical University. doi: 10.12259/j.issn.2095-610X.S202607

Citation:

Xin LIU, Changyu LI, Na LI, Jing QIANG, Rong JI, Wenhui MENG, Zesheng ZHANG. Predictive Value of INETs combined with Neutrophil Indicators for Thromboembolic Complications in Patients under ECMO Assistance[J]. Journal of Kunming Medical University. doi: 10.12259/j.issn.2095-610X.S202607

Citation:

Xin LIU, Changyu LI, Na LI, Jing QIANG, Rong JI, Wenhui MENG, Zesheng ZHANG. Predictive Value of INETs combined with Neutrophil Indicators for Thromboembolic Complications in Patients under ECMO Assistance[J]. Journal of Kunming Medical University. doi: 10.12259/j.issn.2095-610X.S202607

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Predictive Value of INETs combined with Neutrophil Indicators for Thromboembolic Complications in Patients under ECMO Assistance

doi: 10.12259/j.issn.2095-610X.S202607

Department of Cardiovascular Surgery，Inner Mongolia Autonomous Region People’s Hospital，Hohhot Inner Mongolia 010010，China

Received Date: 2026-02-02

Abstract

Abstract

Objective To evaluate the predictive value of neutrophil extracellular traps （NETs）–related indicators combined with neutrophil functional indices for thrombotic complications in patients receiving extracorporeal membrane oxygenation （ECMO） support. Methods The single-center prospective cohort study consecutively enrolled 100 patients receiving ECMO-assisted therapy at the Inner Mongolia Autonomous Region People's Hospital from January 2023 to December 2024. Patients were divided into non-thrombotic complication group and thrombotic complication group based on the presence or absence of thrombotic complications. The total study population was further divided into MACE group and non-MACE group according to the occurrence of MACE events. General patient data, medical history, and ECMO-related parameters were collected.Routine blood tests, coagulation function, NETs markers [myeloperoxidase-DNA complexes （MPO-DNA） and citrullinated histone H3 （CitH3）], and neutrophil functional indices [surface markers （CD11b, CD62L） and reactive oxygen species （ROS） production]were measured. Thrombotic complications were identified through imaging examinations and clinical evaluation. The predictive value of each indicator was assessed using t-test, chi-square test, correlation analysis, and receiver operating characteristic （ROC） curve analysis. Results Among the 100 patients, 30 （30.0%） developed thrombotic complications. MPO levels were significantly higher in the thrombosis group than in the non-thrombosis group （P < 0.05）. During follow-up, 23 patients experienced MACE. Levels of MPO and ceruloplasmin （CER） were significantly higher in the MACE group （P < 0.05）. CER levels were correlated with MPO levels （r = 0.333, P < 0.001）. ROC analysis showed that MPO had better predictive performance for MACE than CER （AUC: 0.867 vs 0.856, P < 0.05）, whereas CER demonstrated better performance in predicting thrombotic complications than MPO（AUC: 0.865 vs 0.825, P < 0.05）. Conclusion NETs-related indicators combined with neutrophil functional indices have potential predictive value for thrombotic complications in ECMO-supported patients and may aid in clinical risk assessment.
- ECMO,
- Thromboembolic complications,
- Neutrophils,
- NETs

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References(18)

References

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