Immunopathogenesis of Lichen Planus

Rongyu YANG; Zehua HAN; Xiaotong LIU; Rong LI; Junli HE; Yingying XIANG

doi:10.12259/j.issn.2095-610X.S20261017

Volume 47 Issue 10

Oct. 2026

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Rongyu YANG, Zehua HAN, Xiaotong LIU, Rong LI, Junli HE, Yingying XIANG. Immunopathogenesis of Lichen Planus[J]. Journal of Kunming Medical University, 2026, 47(10): 170-180. doi: 10.12259/j.issn.2095-610X.S20261017

Citation:

Rongyu YANG, Zehua HAN, Xiaotong LIU, Rong LI, Junli HE, Yingying XIANG. Immunopathogenesis of Lichen Planus[J]. Journal of Kunming Medical University, 2026, 47(10): 170-180. doi: 10.12259/j.issn.2095-610X.S20261017

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Immunopathogenesis of Lichen Planus

doi: 10.12259/j.issn.2095-610X.S20261017

1.
Section of Oral Medicine，Department of Stomatology，School of Clinical Medicine, Medical College，Dali University，Dali Yunnan 671000
2.
Department of Stomatology，Yan’an Hospital Affiliated to Kunming Medical University，Kunming Yunnan 650031
3.
School of Stomatology，Kunming Medical University Haiyuan College，Kunming Yunnan 650106，China

Received Date: 2026-05-29
Available Online: 2026-10-10
Publish Date: 2026-10-30

Abstract

Abstract

Lichen planus is a chronic, immune-mediated inflammatory disease characterized by lichenoid interface dermatitis. Its development results from interactions between genetic susceptibility and environmental factors. The immune mechanisms are predominantly T-cell mediated: IFN-γ, TNF-α, and the IL-23/Th17 axis drive inflammation, while CD8⁺cytotoxic T cells induce keratinocyte apoptosis via the perforin/granzyme B and Fas/FasL pathways. JAK-STAT signaling and metabolic abnormalities further amplify the inflammatory response. A systematic review of the etiology, immunopathogenesis, and clinical associations of LP provides a theoretical basis for precision subtyping and targeted therapy.
- Lichen planus,
- Immunity,
- Pathogenesis

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References(78)

References

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