Correlation and Significance of FCN3，IGF-1 and Immune Function in Children with Recurrent Respiratory Tract Infection

Jing LAN; Huaying YANG; Jianhong CHENG

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Jing LAN, Huaying YANG, Jianhong CHENG. Correlation and Significance of FCN3，IGF-1 and Immune Function in Children with Recurrent Respiratory Tract Infection[J]. Journal of Kunming Medical University.

Citation:

Jing LAN, Huaying YANG, Jianhong CHENG. Correlation and Significance of FCN3，IGF-1 and Immune Function in Children with Recurrent Respiratory Tract Infection[J]. Journal of Kunming Medical University.

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Correlation and Significance of FCN3，IGF-1 and Immune Function in Children with Recurrent Respiratory Tract Infection

Department of Pediatrics，Zigong Maternal and Child Health Hospital，Zigong Sichuan 643000，China

Received Date: 2025-09-28
Available Online: 2026-01-03

Abstract

Abstract

Objective To investigate the efficacy of combining serum fibronectin 3 （FCN3） with insulin-like growth factor 1 （IGF-1） in evaluating recurrent respiratory tract infections （RRTIs） in children and its correlation with immune function. Methods A total of 142 children with RRTIs （RRTIs group） and 142 children with acute occasional respiratory tract infection （infection group） admitted to Zigong Maternal and Child Health Hospital from September 2022 to August 2024 were selected. Additionally, 50 healthy children during the same period were selected as the control group. Another 50 children with respiratory tract infection from September 2024 to January 2025 were selected as the validation set for prospective cohort validation. The baseline data and serum levels of FCN3 and IGF-1 were compared among the three groups. The evaluation value of FCN3 and IGF-1 for the risk of RRTIs was analyzed. The immune functions （CD3⁺ T lymphocytes, CD4⁺ T lymphocytes, CD4⁺/CD8⁺） were compared among the three groups, and their correlation with serum level of FCN3 and IGF-1 was analyzed. Results The levels of serum FCN3 and IGF-1 in the RRTIs group were lower than those in the infection group and the control group （P < 0.05）, the level of serum FCN3 in the infection group was lower than that in the control group, However, there was no significant difference in the levels of serum IGF-1 between the infection group and the control group （P > 0.05）. Elevated FCN3 and IGF-1 were independently associated protective factors for RRTIs （P < 0.05）. The AUC value of the combined evaluation of RRTIs using serum FCN3 and IGF-1 is greater than that of serum FCN3 and IGF-1 （P < 0.05）. The levels of CD3⁺ T lymphocytes, CD4⁺ T lymphocytes, and CD4⁺/CD8⁺ in the RRTIs group were lower than those in the infection group and the control group, with the infection group having lower levels than the control group （P < 0.05）. The levels of serum FCN3 and IGF-1 were positively correlated with CD3⁺ T lymphocytes, CD4⁺ T lymphocytes, and CD4⁺/CD8⁺ （all P < 0.05）. The Kappa value consistency analysis showed that the coincidence rate of the ROC results of FCN3 and IGF-1 combined with clinical practice in the validation set was 90.00 %, and the Kappa value was 0.799 （95%CI: 0.524～0.912）（P < 0.001）. Conclusion The levels of serum FCN3 and IGF-1 in children with RRTIs are closely related to immune function, and the combined detection of their levels has certain evaluation value for the risk of RRTIs.
- Repeated respiratory tract infection,
- Fibroin 3,
- Insulin-like growth factor 1,
- Evaluation

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References(23)

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