Application of miR-132，BDNF and NRG-1 in the Diagnosis and Prognosis of AI-related Vascular Dementia

Saibing LIU; Liping YAN; Ani SUN

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Saibing LIU, Liping YAN, Ani SUN. Application of miR-132，BDNF and NRG-1 in the Diagnosis and Prognosis of AI-related Vascular Dementia[J]. Journal of Kunming Medical University.

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Saibing LIU, Liping YAN, Ani SUN. Application of miR-132，BDNF and NRG-1 in the Diagnosis and Prognosis of AI-related Vascular Dementia[J]. Journal of Kunming Medical University.

Saibing LIU, Liping YAN, Ani SUN. Application of miR-132，BDNF and NRG-1 in the Diagnosis and Prognosis of AI-related Vascular Dementia[J]. Journal of Kunming Medical University.

Citation:

Saibing LIU, Liping YAN, Ani SUN. Application of miR-132，BDNF and NRG-1 in the Diagnosis and Prognosis of AI-related Vascular Dementia[J]. Journal of Kunming Medical University.

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Application of miR-132，BDNF and NRG-1 in the Diagnosis and Prognosis of AI-related Vascular Dementia

1.
Department of Neurology
2.
Department of Neurology III，Xi’an Gaoxin Hospital，Xi’an Shaanxi 710075，China

Received Date: 2025-09-23
Available Online: 2026-01-03

Abstract

Abstract

Objective To discuss the application of serum microRNA-132 （miR-132） jointed with brain-derived neurotrophic factor （BDNF） and neuregulin-1 （NRG-1） in the diagnosis and prognosis evaluation of acute ischemic stroke （AIS）-related vascular dementia （VD）. Methods A total of 183 patients with AIS and complicated VD admitted to Xi'an Gaoxin Hospital from August 2022 to January 2025 were included as the VD group. They were followed up for 6 months and separated into adverse group （n = 54） and good group （n = 129） based on their prognosis. Another 175 AIS patients who did not have complicated VD during the same period were included as the non VD group. In addition, the influencing factors of poor prognosis in patients with AIS and complicated VD and the predictive efficacy of serum miR-132, BDNF, and NRG-1 levels for poor prognosis in patients with AIS and complicated VD were discussed. Results The levels of serum miR-132, BDNF and NRG-1 in the VD group were all lower than those in the non-VD group （P < 0.05）. Serum miR-132, BDNF and NRG-1 were the influencing factors of AIS complicated with VD （P < 0.05）. The AUC （0.860） of the jointed diagnosis for AIS complicated with VD was higher than that of the individual diagnosis （0.796, 0.758, 0.713）（P < 0.05）. Compared with the good group, the poor group had a higher proportion of admission MMSE scores ≤ 20, and lower levels of serum miR-132, BDNF, and NRG-1 （P < 0.05）. Serum miR-132, BDNF, and NRG-1 were prognostic factors in patients with AIS and complicated VD （P < 0.05）. The AUC of the jointed prediction （0.920） for the prognosis of patients with AIS and complicated VD was obviously higher than that of the individual predictions of each indicator （0.806, 0.788, 0.850）. Conclusion Serum miR-132, BDNF, and NRG-1 are all reduced in patients with AIS and complicated VD. The combined detection of these three markers may have certain application value in the diagnosis and prognosis evaluation of AIS-related vascular disease.
- MicroRNA-132,
- Brain-derived neurotrophic factor,
- Neuregulin-1,
- Acute ischemic stroke,
- Vascular dementia,
- Prognosis

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References(23)

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