Research Progress and Application Prospects of Neuroglia-associated Exosomes in Schizophrenia

Biyao GAO; Fuyi QIN; Yilin LIU; Jia WEN; Xinrui LI; Yuan FANG; Yunqiao ZHANG

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Biyao GAO, Fuyi QIN, Yilin LIU, Jia WEN, Xinrui LI, Yuan FANG, Yunqiao ZHANG. Research Progress and Application Prospects of Neuroglia-associated Exosomes in Schizophrenia[J]. Journal of Kunming Medical University.

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Research Progress and Application Prospects of Neuroglia-associated Exosomes in Schizophrenia

Department of Psychiatry，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2025-03-18
Available Online: 2026-03-29

Abstract

Abstract

Schizophrenia is a severe mental disorder with complex etiology, and its pathogenesis involves the interaction of multiple factors including genetics, environment, and neurobiology. In recent years, exosomes, as the primary mediators of intercellular communication, have provided new possibilities for studying the etiology of schizophrenia, developing diagnostic methods, and identifying therapeutic approaches. This review summarizes the role of glial cells as both source cells and targets of exosomes, their involvement in the pathogenesis and development of schizophrenia, and their potential as diagnostic biomarkers and drug delivery vehicles.The review provides new perspectives and theoretical evidence for the application of exosomes in the diagnosis and treatment of schizophrenia.
- Schizophrenia,
- Exosomes,
- Neuroglia,
- Neuroinflammation,
- Biomarkers,
- Drug delivery

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References(62)

References

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