Relationship Between Serum CD46，KLF7，FURIN and Clinicopathological Features in Patients with Chronic Cervicitis Combined with HPV Infection and Their Prognostic Predictive Value

Zhiying ZHANG; Peijing SHI

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Zhiying ZHANG, Peijing SHI. Relationship Between Serum CD46，KLF7，FURIN and Clinicopathological Features in Patients with Chronic Cervicitis Combined with HPV Infection and Their Prognostic Predictive Value[J]. Journal of Kunming Medical University.

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Relationship Between Serum CD46，KLF7，FURIN and Clinicopathological Features in Patients with Chronic Cervicitis Combined with HPV Infection and Their Prognostic Predictive Value

Zhiying ZHANG¹,
Peijing SHI^{2
,
,}

1.
Department of Health Examination，Yantai Mountain Hospital，Yantai Shandong 264000
2.
Department of Gynecology，The Third People’s Hospital of Jinan ，Jinan Shandong 250132，China

Received Date: 2025-10-23

Abstract

Abstract

Objective To investigate the relationship between serum membrane cofactor protein （CD46）, Krüppel-like factor 7 （KLF7）, Furin protease （FURIN） and clinical-pathological characteristics of chronic cervicitis combined with HPV infection, and their predictive value for prognosis. Methods A total of 217 patients diagnosed with chronic cervicitis complicated by HPV infection, 217 patients with chronic cervicitis, and 217 healthy volunteers from gynecological examination admitted to Yantai Mountain Hospital between December 2022 and December 2024 were enrolled in this study and divided into chronic cervicitis with HPV group, chronic cervicitis group, and healthy control group, respectively. Based on evaluation of therapeutic efficacy after three months of treatment, patients in the chronic cervicitis with HPV group were divided into significant efficacy group （n = 133） and poor efficacy group （n = 84）. Serum levels of CD46, KLF7, and FURIN were measured using ELISA. Spearman and Pearson correlation analyses were employed to assess the correlation between these biomarker levels, HPV risk stratification, and inflammatory cytokine levels. Cox regression analysis was employed to screen for factors affecting poor efficacy in cervicitis complicated with HPV patients. ROC curve analysis was used to evaluate the value of CD46, KLF7, and FURIN levels in predicting poor efficacy in cervicitis combined with HPV patients. Relative risks of poor efficacy at different cutoff values of CD46, KLF7, and FURIN were compared. Results Serum levels of CD46, KLF7, and FURIN in the cervicitis complicated with HPV group were progressively elevated compared to the cervicitis group and healthy control group （P < 0.05）. Serum CD46, KLF7, and FURIN levels in the cervicitis combined with HPV group were significantly higher than those in the cervicitis group and healthy control group （P < 0.05）, and the cervicitis group was higher than the healthy control group （P < 0.05）. Serum CD46, KLF7, and FURIN levels in the high-risk HPV type group were significantly higher than those in the intermediate-risk and low-risk type groups （P < 0.05）, and the intermediate-risk group was higher than the low-risk group （P < 0.05）. Inflammatory factors IL-10 and TNF-α levels in the cervicitis combined with HPV group were higher than those in the cervicitis group （P < 0.05）, while IFN-γ levels were lower （P < 0.05）. Spearman correlation analysis showed that CD46, KLF7, and FURIN levels were positively correlated with HPV risk stratification （r_s = 0.523, 0.486, 0.507, P < 0.05）. Pearson correlation analysis demonstrated that CD46, KLF7, and FURIN levels were positively correlated with IL-10 and TNF-α （r = 0.492, 0.535, 0.527, P < 0.05） and negatively correlated with IFN-γ （r = −0.538, −0.511, −0.479, P < 0.05）. Serum CD46, KLF7, and FURIN levels in the poor efficacy group were significantly higher than those in the significant efficacy group （P < 0.05）; there was no statistically significant difference in age and BMI between the two groups （P > 0.05）. Univariate Cox proportional hazards regression analysis showed that neither age nor BMI was associated with poor efficacy in cervicitis combined with HPV patients （P > 0.05）. Multivariate Cox regression analysis including significant variables revealed that elevated CD46, KLF7, and FURIN levels were all independent factors affecting poor efficacy in cervicitis combined with HPV patients （P < 0.05）. The combined AUC of CD46, KLF7, and FURIN for predicting poor efficacy in cervicitis combined with HPV patients was 0.947 （95%CI: 0.918～0.975）, which was superior to the individual AUC values of CD46 （Z = 2.862, P < 0.05）, KLF7 （Z = 3.584, P < 0.05）, and FURIN （Z = 3.116, P < 0.05）. The relative risk of poor prognosis in cervicitis combined with HPV patients with CD46≥253.39, KLF7≥5.91, and FURIN≥135.41 expression was 1.958, 1.691, and 2.041 times that of patients with CD46 < 253.39, KLF7 < 5.91, and FURIN < 135.41, respectively （χ² = 34.775, 22.380, 40.412, P < 0.05）. Conclusion Serum CD46, KLF7, and FURIN levels are elevated in patients with chronic cervicitis combined with HPV infection, and all three are correlated with HPV risk stratification and inflammatory factor levels. The combined detection of CD46, KLF7, and FURIN has high predictive value for poor efficacy in cervicitis combined with HPV patients.
- CD46,
- KLF7,
- FURIN,
- Chronic cervicitis complicated with HPV infection,
- Clinical pathological features,
- Prognosis,
- Prediction

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