Predictive Value of Lp-PLA2，sdLDL-C and 25-OH-VD on the Degree of Neurological Impairment and Prognosis in Ischemic Stroke After Intravenous Thrombolysis

Rui WANG; Junxing SONG; Yaru WANG; Hao REN; Hui JI; Mei CHEN

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Article Navigation > Journal of Kunming Medical University > 2026 > Accepted Manuscript

Rui WANG, Junxing SONG, Yaru WANG, Hao REN, Hui JI, Mei CHEN. Predictive Value of Lp-PLA2，sdLDL-C and 25-OH-VD on the Degree of Neurological Impairment and Prognosis in Ischemic Stroke After Intravenous Thrombolysis[J]. Journal of Kunming Medical University.

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Predictive Value of Lp-PLA2，sdLDL-C and 25-OH-VD on the Degree of Neurological Impairment and Prognosis in Ischemic Stroke After Intravenous Thrombolysis

1.
Department of Neurology，Harison International Peace Hospital，Hengshui Hebei 053000，China
2.
Nursing Department，Internal Nursing Teaching and Research Office，Jiazhuang Medical College Shijiazhuang Hebei 05000，China

Received Date: 2026-03-14

Abstract

Abstract

Objective To explore the predictive value of lipoprotein-associated phospholipase A2 （Lp-PLA2）, small dense low-density lipoprotein cholesterol （sdLDL-C）, and 25-hydroxyvitamin D （25-OH-VD） on the degree of neurological impairment and prognosis in patients with ischemic stroke after intravenous thrombolysis. Methods A retrospective analysis was conducted on the medical data of 108 patients with ischemic stroke who received intravenous thrombolysis at Harrison International Peace Hospital from January 2021 to June 2023. Based on the National Institute of Health Stroke Scale （NIHSS） score at admission, patients were divided into mild group （NIHSS < 5, n = 49）, moderate group （NIHSS 5–15, n = 35）, and severe group （NIHSS > 15, n = 24）. Serum levels of Lp-PLA2, sdLDL-C and 25-OH-VD were detected using enzyme-linked immunosorbent assay. Differences in Lp-PLA2, sdLDL-C and 25-OH-VD levels among groups were compared. Spearman correlation analysis was used to explore the relationship between Lp-PLA2, sdLDL-C, 25-OH-VD and the degree of neurological impairment. Receiver operating characteristic （ROC） curves were constructed to evaluate the value of Lp-PLA2, sdLDL-C and 25-OH-VD in assessing disease severity and predicting prognosis. Results The levels of Lp-PLA2, sdLDL-C, NIHSS score and infarct lesion diameter gradually increased, while 25-OH-VD level gradually decreased in the mild, moderate and severe groups （P < 0.05）. Lp-PLA2 and sdLDL-C were positively correlated with disease severity of neurological injury, whereas 25-OH-VD was negatively correlated. The combined detection of the three indicators showed the optimal ROC efficacy in assessing stroke severity and predicting poor prognosis. Conclusion Levels of Lp-PLA2, sdLDL-C and 25-OH-VD are closely associated with the degree of neurological impairment in patients with ischemic stroke after intravenous thrombolysis. The combined detection of the three indicators shows high predictive efficacy for disease severity and prognosis, and can be used as an important reference for clinical evaluation.
- Ischemic Stroke,
- Degree of neurological Impairment,
- Prognosis,
- Lipoprotein-associated phospholipase A2,
- Small dense low-density lipoprotein cholesterol,
- 25-Hydroxyvitamin D

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References(25)

References

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