Correlation Study of Brain Structural and Functional Alterations with the rs12678428 Polymorphism in Adults with Childhood Left-Behind Experiences

Menghua LV; Yin MO

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Menghua LV, Yin MO. Correlation Study of Brain Structural and Functional Alterations with the rs12678428 Polymorphism in Adults with Childhood Left-Behind Experiences[J]. Journal of Kunming Medical University.

Citation:

Menghua LV, Yin MO. Correlation Study of Brain Structural and Functional Alterations with the rs12678428 Polymorphism in Adults with Childhood Left-Behind Experiences[J]. Journal of Kunming Medical University.

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Correlation Study of Brain Structural and Functional Alterations with the rs12678428 Polymorphism in Adults with Childhood Left-Behind Experiences

Menghua LV,
Yin MO^,

Department of Medical Imaging，The First Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2026-03-03

Abstract

Abstract

Objective To explore the effects of childhood left-behind experiences and the depression-related risk gene rs12678428 polymorphism on brain structure and function in adulthood. Methods Healthy adults from southern China, with or without left-behind experiences, were recruited between September 2022 and August 2025. Demographic data, venous blood samples and MRI data were collected. Participants were divided into two genotype groups according to the presence of the T allele of rs12678428: TT+TC and CC. Gray matter volume （GMV）, amplitude of low-frequency fluctuation （ALFF）, fractional ALFF （fALFF）, regional homogeneity （ReHo）, and degree centrality （DC） were compared between different genotypes in the non-left-behind and left-behind groups. The functions of differential brain regions were analyzed, and the relationships among left-behind experience, rs12678428 polymorphism, and brain structure and function were further explored. Results No significant differences in gender, age, or education level were found between the TT+TC and CC groups （P >  0.05）. In the non-left-behind group, significant differences in GMV, ALFF, ReHo, and DC were observed between TT+TC and CC genotypes （P < 0.05）, mainly in the bilateral insula, temporal lobe, postcentral gyrus and fusiform gyrus. In the left-behind group, significant differences in GMV, ALFF, fALFF, and ReHo were found between TT+TC and CC genotypes（P <  0.05）, predominantly in the bilateral pericalcarine cortex, lingual gyrus, precentral gyrus, postcentral gyrus and caudate nucleus. Conclusion The rs12678428 gene polymorphism is closely associated with alterations in brain structure and function, and left-behind experiences may modulate its pattern of effects.
- Rs12678428,
- Childhood left-behind experience,
- Adults,
- Brain structure,
- Brain function

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References(22)

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