Effect of Ma Xiong Shu Tong Fang on Migraine and Its Influence on Serum Levels of 5-HT, NF-NF-κB and Inflamatory Cytokines

Zhang Jin Pei; Yang Yi; Jin Yan

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Zhang Jin Pei , Yang Yi , Jin Yan . Effect of Ma Xiong Shu Tong Fang on Migraine and Its Influence on Serum Levels of 5-HT, NF-NF-κB and Inflamatory Cytokines[J]. Journal of Kunming Medical University, 2017, 38(08): 40-43.

Citation:

Zhang Jin Pei , Yang Yi , Jin Yan . Effect of Ma Xiong Shu Tong Fang on Migraine and Its Influence on Serum Levels of 5-HT, NF-NF-κB and Inflamatory Cytokines[J]. Journal of Kunming Medical University, 2017, 38(08): 40-43.

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Effect of Ma Xiong Shu Tong Fang on Migraine and Its Influence on Serum Levels of 5-HT, NF-NF-κB and Inflamatory Cytokines

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基金：国家自然科学基金资助项目 (81470188);

Received Date: 2017-05-10

Abstract

Abstract

Objective To study the safety and effectiveness of Ma Xiong Shu Tong Fang for migraine and evaluate the white matter lesions (WML) by brain MRI.Methods A total of 122 consecutives were randomly divided into control and observation groups and each group had 61 cases.The patients in control group received Flunarizine Hydrochloride Capsules 10 mg/d, and the patients in observation group adopted Ma Xiong Shu Tong Fang three particles per day, and the course was four weeks. Then we compared TCM syndrome integrals, total effective rate and incidence of adverse reactions, serum 5-HT, NF-κB, IL-6 and TNF-αlevels, positive rate and degrees of WML by MRI. Results The TCM syndrome integrals after treatment in observation group was significantly lower than control group (P <0.05) . There were no severe complications in the two groups. The serum 5-HT, NF-κB, IL-6 and TNF-αlevels in observation group were all lower, positive rate of WML was also lower (P<0.05) . Conclusion Ma Xiong Shu Tong Fang is safe and effective for mgraine, it can reduce serum levels of 5-HT, NF-κB, IL-6 and TNF-αand improve WML.
- Ma Xiong Shu Tong Fang,
- Migraine,
- White matter lesions,
- 5-HT,
- NF-κB,
- IL-6

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References(9)

References

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