The Expression and Significance of IL-17 and IL-23 in Patients with B-cell non-Hodgkin Lymphoma Treated by RCHOP

Huang Ying; Liu Yi Han; Li Cheng Ping; Wu Kun; Zeng Yun

Article Contents

Article Navigation > Journal of Kunming Medical University > 2017 > 38(08): 67-72

Huang Ying , Liu Yi Han , Li Cheng Ping , Wu Kun , Zeng Yun . The Expression and Significance of IL-17 and IL-23 in Patients with B-cell non-Hodgkin Lymphoma Treated by RCHOP[J]. Journal of Kunming Medical University, 2017, 38(08): 67-72.

Citation:

Huang Ying , Liu Yi Han , Li Cheng Ping , Wu Kun , Zeng Yun . The Expression and Significance of IL-17 and IL-23 in Patients with B-cell non-Hodgkin Lymphoma Treated by RCHOP[J]. Journal of Kunming Medical University, 2017, 38(08): 67-72.

Citation:

PDF( 551 KB)

The Expression and Significance of IL-17 and IL-23 in Patients with B-cell non-Hodgkin Lymphoma Treated by RCHOP

Funds:

基金：云南省教育厅科学研究基金资助项目 (2013Y292);

Received Date: 2017-05-03

Abstract

Abstract

Objectives To detect the expression levels of IL-17 and IL-23 in peripheral blood of B-cell non-Hodgkin lymphoma patients treated by RCHOP and to study the role of IL-17 and IL-23 in NHL.Methods Twenty-five patients with B-cell NHL who achieved remission after 6 to 8 cycles of R-CHOP as a NHL group, 20 healthy volunteers were recruited as a normal control group.RT-PCR was used to detect the expression levels of IL-17 m RNA and IL-23 m RNA in NHL patients and health volunteers.Results The expression levels of IL-17 m RNA and IL-23 m RNA in the patients with NHL before therapy and the patients with NHL who achieved remission were lower than that in the normal control group (P<0.05) .The expression levels of IL-17 m RNA and IL-23 m RNA in the patients with NHL who achieved remission were higher than that in the patients with NHL before therapy (P=0.001, P<0.05) .Conclusions IL-17 and IL-23 m RNA levels are higher after treated with R-CHOP. The expression levels of IL-17 m RNA and IL-23 m RNA in NHL patients are related with prognosis and efficacy.
- Non-Hodgkin lymphoma,
- Interleukin-17,
- Interleukin-23,
- Rituximab,
- Prognosis

FullText(HTML)

References(13)

References

[1]	[1]SIEGEL R L, MILLER K D, JEMAL A.Cancer statistics, 2015[J].CA Cancer J Clin, 2015, 65 (1) :5-29.
[2]	[2]STASICR, DELPOETAG, STIPAE, et al.Response to B-cell depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura[J].Blood, 2007, 110 (8) :2924-2930.
[3]	[3]STASI R, COOPERN, DELPOETAG, et al.Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab[J].Blood, 2008, 112 (4) :1147-1150.
[4]	[4]SHAHRARAS, HUANGQ, MANDELINAM, et al.TH-17 cells in rheumatoid arthritis[J].Arthritis Res Ther, 2008, 10 (4) :R93.
[5]	[5]RACKEMK.Immunopathogenesis of multiple sclerosis[J].Ann Indian Acad Neurol, 2009, 12 (4) :215-220.
[6]	[6]ZHOU L, LITTMANDR.Transcriptional regulatory networks in Th17 cell differentiation[J].Curr Opin Immunol, 2009, 21 (2) :146-152.
[7]	[7]STARK M A, HUO Y, BURCIN T L, et al.Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17[J].Immunity, 2005, 22 (3) :285-294.
[8]	[8]TZANKOVA, MEIERC, HIRSCHMANNP, et al.Correlation of high numbers of intratumoral FOXP3+regulatory T cells with improved survival in germinal center like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma[J].Haematologica, 2008, 93 (2) :193-200.
[9]	[9]GHILARDIN, OUYANGW.Targeting the development and effector functions of TH17 cells[J].Semin Immunol, 2007, 19 (6) :383-393.
[10]	[10]SAKAGUCHI S.Regulatory T cells:Key controllers of immunologic self-tolerance[J].Cell, 2000, 101 (5) :455-458.
[11]	[11]PARK H, LIZ, YANGXO, et al.A distinct lineage of CD4T cells regulates tissue inflammation by producing interleukin 17[J].Nat Immunol, 2005, 6 (11) :1133-1141.
[12]	[12]OPPMANNB, LESLEYR, BLOMB, et al.Novel p19 protein engages IL-12p40 to form a cytokine from a cytokine, IL-23, with biological activities similar as well as distinct from IL-12[J].Immunity, 2000, 13 (5) :715-725.
[13]	[13]LU T, YUS, LIUY, et al.Aberrant circulating Th17 cells in patients with B-cell non-hodgkin’s lymphoma[J].PLo S One, 2016, 11 (1) :e0148044.

Relative Articles(20)

Relative Articles

[1]	Xinyi MEN, Jing ZHAO, Yongchun SHEN, Hui JI, Xiuxia WANG. The Relationship between Peripheral Blood Immunoglobulin，Erythrocyte Sedimentation Rate，Homocysteine and the Degree of Central Nervous System Vasculitis in Children and Their Influence on Prognosis. Journal of Kunming Medical University, 2024, 45(12): 1-7.
[2]	Xingxu LIU, Meihua LI, Chaofeng REN, Weiping WANG, Li LI, Yuan BO, Chunmei ZHANG, Jing JIANG, Zhangmin ZHENG, Dongyu ZHOU. Correlation Between KL-6，IL-17 and CTD-ILD. Journal of Kunming Medical University, 2024, 45(10): 111-115. doi: 10.12259/j.issn.2095-610X.S20241017
[3]	Chunyan LIU, Bingqing CHANG, Chao LI, Xin REN, Xiaoqin LIU. The Relationship between T Lymphocyte Subsets and Pathological Characteristics of Acute Myeloid Leukemia and the Value of Predicting Chemotherapy Prognosis. Journal of Kunming Medical University, 2024, 45(5): 116-122. doi: 10.12259/j.issn.2095-610X.S20240518
[4]	Qi NIE, Li LIU, Yue TIAN, Xiaoyan MAO, Qulian GUO, Xin TIAN. Abnormal Clinical Features and Prognosis of ACTH in Pediatric Acute B Lymphocytic Leukemia. Journal of Kunming Medical University, 2024, 45(10): 75-84. doi: 10.12259/j.issn.2095-610X.S20241012
[5]	Jiadai TANG, Jing YANG, Hongli SONG, Jiaojiao CHEN, Zhonghui MIAO, Lin XIE. Correlation of Metastatic and Prognostic Factors in 318 Cases of Primary Gastric Cancer. Journal of Kunming Medical University, 2023, 44(2): 75-87. doi: 10.12259/j.issn.2095-610X.S20230218
[6]	Ting GAO, Sheng HUANG, Rong GUO, Dedian CHEN. Clinicopathological Features and Prognosis of Mucinous Breast Carcinoma. Journal of Kunming Medical University, 2023, 44(3): 54-60. doi: 10.12259/j.issn.2095-610X.S20230306
[7]	Xiaohua LU, Hongxin YUAN. The Analysis of the Correlation between BTLA，CTLA-4 Gene Polymorphisms and the Efficacy and Prognosis of TACE Combined Targeted Therapy for Liver Cancer. Journal of Kunming Medical University, 2023, 44(9): 126-135. doi: 10.12259/j.issn.2095-610X.S20230927
[8]	Xia ZHANG, Wensha NIE, Huiping WANG, Zuohua WANG, Chunxia WANG, Yuxia ZHENG. Efficacy of Rituximab Combined with Methylprednisolone in the Treatment of Autoimmune Encephalitis and Its Effect on Peripheral Blood PD-1 and PD-L1. Journal of Kunming Medical University, 2023, 44(4): 123-127. doi: 10.12259/j.issn.2095-610X.S20230428
[9]	Changmeng HU, Lin WU. Correlation Between Silva Type and Prognosis of Cervical HPV-associated Adenocarcinoma. Journal of Kunming Medical University, 2022, 43(8): 113-121. doi: 10.12259/j.issn.2095-610X.S20220817
[10]	Bo TIAN, Yinzhong SHEN, Jinsong BAI, Jun LIU, Haiyun CHEN, Jianjun SUN. Clinical Characteristics of Talaromyces Marneffei Disease and Disseminated Nontuberculosis Mycobacterium Disease in AIDS Patients. Journal of Kunming Medical University, 2022, 43(7): 140-144. doi: 10.12259/j.issn.2095-610X.S20220718
[11]	Shizhou LI, Xiaoguang HE, Yan LIN, Yuxiao LI, Xi YANG, Xiaoyu WANG, Shenghao YANG. Clinical Analysis of Cervical Lymph Node Metastatic Squamous Cell Carcinoma of Unknown Primary Site. Journal of Kunming Medical University, 2022, 43(7): 80-85. doi: 10.12259/j.issn.2095-610X.S20220710
[12]	Honglan CHEN, Yi WU, Tao HU, Yuming WANG. Potential Value of G6PD Activity Detection in the Peripheral Blood for the Diagnosis and Prognosis of Cervical Cancer Patients with High Risk Human Papillomavirus Infection. Journal of Kunming Medical University, 2022, 43(2): 89-95. doi: 10.12259/j.issn.2095-610X.S20220203
[13]	Jian-pei SU, Wei-meng TIAN, Jun GU, Mi-yu HE. Association between C-reactive Protein/Albumin Ratio and Long-term Prognosis in Elderly Patients with Heart Failure. Journal of Kunming Medical University, 2020, 41(12): 128-132. doi: 10.12259/j.issn.2095-610X.S20201236
[14]	Zhang Ai Ling . Conventional Segmentation and Large Fractionated Three-dimensional Conformal Radiotherapy in the Treatment of Non Small Cell Lung Cancer with Superior Vena Cava Syndrome. Journal of Kunming Medical University,
[15]	Nie Bo . Clinical Characteristic of 34 Patients with Extranodal Nasal Type NK/T-Cell Lymphoma. Journal of Kunming Medical University,
[16]	Huang Ying , Liu Yi Han , Li Cheng Ping , Wu Kun , Zeng Yun . Expression of IL-17 and IL-23 in Patients with B-cell non-HodgkinLymphoma Treated by RCHOP. Journal of Kunming Medical University, 2016, 37(12): 76-81.
[17]	Liu Ju Peng . . Journal of Kunming Medical University,
[18]	Yang Jing . . Journal of Kunming Medical University,
[19]	Shi Lei . . Journal of Kunming Medical University,
[20]	Liu Jian Gang . . Journal of Kunming Medical University,