Bao Yu Lian , Zhu Yu Hong , Li Qin , Bao Tian Hao . A Study of microRNA-124 Expression in blood Serum of Patients with Intracerebral Hemorrhage[J]. Journal of Kunming Medical University, 2018, 39(02): 100-103.
Citation: Bao Yu Lian , Zhu Yu Hong , Li Qin , Bao Tian Hao . A Study of microRNA-124 Expression in blood Serum of Patients with Intracerebral Hemorrhage[J]. Journal of Kunming Medical University, 2018, 39(02): 100-103.

A Study of microRNA-124 Expression in blood Serum of Patients with Intracerebral Hemorrhage

Funds:

基金: 国家自然科学基金项目 (81060102); 云南省科技计划项目 (2017FE467-152);

  • Received Date: 2017-10-19
  • Objective To observe microRNA-124 expression in the serum of patient with intracerebral hemorrhage and explore the relationship between the expression and associated clinical factors. Me thods Thirty serum specimen were collected among patients with intracerebral hemorrhage, who were checked up at the same time in the hospital. Relative expression of microRNA-124 in serum was detected. The variation of Micro RNA-124 expression between the two groups and clinical data of patients with intracerebral hemorrhage were analyzed. The relationship between microRNA-124 and clinical factors related to intracerebral hemorrhage was explored. Re s ults Compared with healthy people, microRNA-124 expression in serum increased among patients with intracerebral hemorrhage (P <0.05) . The expression is related to the bleeding volume and onset time (P <0.05) .Meanwhile, no obvious correlation is established between serum microRNA-124 expression and other factors in patients with intracerebral hemorrhage, such as gender, bleeding area, with or without surgical treatment (including minimally invasive and craniotomy) , a history of high blood pressure, fasting venous blood glucose levels (FPG) , and cerebrovascular disease history (P >0.05) . Conclus ion The serum microRNA-124 expression in patients with intracerebral hemorrhage is higher than that in healthy people. Bleeding volume positively increases expression. A higher expression is seen within one week at the onset of intracerebral hemorrhage compared to that one week after.
  • loading
  • [1] 中华医学会神经病学分会脑血管病学组.中国脑出血诊治指南2014[J].中华神经科杂志, 2015, 48 (6) :435-444.
    [2]
    [2]HARFE B D.Micro RNAs in vertebrate development[J].Curr Opin Genet Dev, 2005, 15 (4) :410-415.
    [3]
    [3]KAO-PING CHANG, HSIAO-CHEN LEE, SHU-HUNG HUANG, et al.Micro RNA Signatures in Ischemia-Reperfusion Injury[J].Annals of Plastic Surgery, 2012, 69 (6) :668-671.
    [4]
    [4] SAYED D, ABDELLATIF M.Micro RNAs in development and disease[J].Physiol Rev, 2011, 91 (3) :827-887.
    [5]
    [5] LUI Z D, TIAN Y, ANDER B P, et al.Brain and blood micro RNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainite seizures[J].J Cerebral Blood Flow Metab, 2010, 30 (1) :92-101.
    [6]彭志锋.下调micro RNA-181b在小鼠缺血性脑损伤中的神经保护作用[J].中国病理生理杂志, 2015, 31 (2) :224-228.
    [7]
    [7]KENNETH J, THOMAS D.Analysis relative gene expression data using real-time quantitative PCR and the 2-△△Ct Methods[J].Methods, 2011, 25 (4) :402-408.
    [8]
    [8] CHEN X, BA Y, MA L, et al.Characterization of micro RNAs in serum:A novel class of biomarkers for diagnosis of cancer and other diseases[J].Cell Res, 2008, 18 (10) :997-1006.
    [9]
    [9] WENG H, SHEN C, HIROKAWA G, et al.Plasma mi R-124 as a biomarker for cerebral infarction[J].Biol Res, 2011, 32 (2) :135-141.
    [10]林洋, 芮耀诚.脑缺血大鼠脑组织及血浆中micro RNA-124a表达的变化[J].中国脑血管病杂志, 2011, 8 (3) :143-147.
    [11]
    [11] DIEHL P, FRICKE A, SANDER L, et al.Microparticles:major transport vehicles for distinct micro RNAs in circulation[J].Cardiovasc Res, 2012, 93 (4) :633-644.
    [12]
    [12] STEINER T, JUVELA S, UNTERBERG A, et al.European stroke organization guidelines for the management of intracranial aneurysms and subarachnoid haemorrhage[J].Cerebrovasc Dis, 2013, 35 (2) :93-112.
    [13]
    [13]LATERZA O F, LIM L, GARRETT-ENGELE P W, et al, Plasma micro RNAs as sensitive and specific biomarkers of tissue injury[J].Clin Chem, 2009, 55 (5) :1977-1983.
    [14]
    [14]LEUNG L Y, CHAN C P, LEUNG Y K, et al.Comparison of mi R-124-3p and mi R-16 for early diagnosis of hemorrhagic ischemic stroke[J].Clin Chim Acta, 2014, 433 (6) :139-144.
  • Relative Articles

    [1] Kun WANG, Jun PU, Tao YANG, Lu WANG, Dongbo LI. Comparison of Effect of Microscopic Surgery via Different Approaches in Treatment of Young Patients with Severe Hypertensivebasal Ganglia Hemorrhage. Journal of Kunming Medical University, 2024, 45(7): 56-61.  doi: 10.12259/j.issn.2095-610X.S20240708
    [2] Xinbang WANG, An HU, Xipeng ZHAO, Yan WANG, Wei DING, Lipeng CAO, Yu GU, Ke XU, Yunfeng ZHANG. Effect of Ommaya Capsule on Cerebral Hemorrhage Complicated with Acute Hydrocephalus and its Effect on Blood-brain Barrier Function. Journal of Kunming Medical University, 2024, 45(10): 96-104.  doi: 10.12259/j.issn.2095-610X.S20241015
    [3] Guangping ZHAO, Panpan LIU, Fei LIU, Wei LI, Yongxue CHEN, Kai ZHANG. Observations on Hemodynamics and Stress Response of the Different Anesthesia Methods in Stereotactic Intracranial Hematoma Removal for Hypertensive Intracerebral Hemorrhage. Journal of Kunming Medical University, 2022, 43(5): 117-122.  doi: 10.12259/j.issn.2095-610X.S20220521
    [4] Ying-xia WANG, Qin HE, Guo-fang WANG, Xuan ZHANG. Expression and Significance of microRNA-21 and EGFR in Non-small Cell Lung Cancer. Journal of Kunming Medical University, 2021, 42(8): 101-105.  doi: 10.12259/j.issn.2095-610X.S20210818
    [5] Yan Ting Ting , Tian Dan , Li Xin , Zu Yun Fen , Li Chong Yang , Shang Xue Qin . . Journal of Kunming Medical University, 2018, 39(09): 15-17.
    [6] Li Ming . Surgical Management of Sylvian Lateral Fissure Approach in the Treatment of Patients with Hypertensive Intracerebral Hemorrhage on Basal Ganglia. Journal of Kunming Medical University,
    [7] Zhan Zi Lan . Influence of Nursing Intervention on Mental State, Complications and Satisfaction in Patients with Cerebral Hemorrhage. Journal of Kunming Medical University,
    [8] Wei Liang , Wang Qi , Yang Cheng , Zhang Yan Fei , Guan Hong Xin , Sun Zhi Yang . The Effects of Mild Hypothermia on MODS Caused by Cerebral Hemorrhage. Journal of Kunming Medical University, 2016, 37(12): 57-61.
    [9] Wang Dan . . Journal of Kunming Medical University,
    [10] Wang Hai Feng . . Journal of Kunming Medical University,
    [11] Liu Le Wan . . Journal of Kunming Medical University,
    [12] Ni Zhong Mei . . Journal of Kunming Medical University,
    [13] Huang Wei . . Journal of Kunming Medical University,
    [14] Gao Li Ping . . Journal of Kunming Medical University,
    [15] Zhang Lei . . Journal of Kunming Medical University,
    [16] Dong Jian Ping . . Journal of Kunming Medical University,
    [17] Liu Ze Fei . . Journal of Kunming Medical University,
    [18] Guo Chang Gui . . Journal of Kunming Medical University,
    [19] . . Journal of Kunming Medical University,
    [20] Zhuang Yong Hui . . Journal of Kunming Medical University,
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1354) PDF downloads(58) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return