A Clinical Study of Combined Therapy of Colchicine and Benzbromarone Capsules in the Treatment of Gouty Arthritis at Non-Acute Episode Stage

Liu Jun Hui; Zhong Fei; Han Shao Ling; Zou Lei

Article Contents

Article Navigation > Journal of Kunming Medical University > 2018 > 39(02): 71-75

Liu Jun Hui , Zhong Fei , Han Shao Ling , Zou Lei . A Clinical Study of Combined Therapy of Colchicine and Benzbromarone Capsules in the Treatment of Gouty Arthritis at Non-Acute Episode Stage[J]. Journal of Kunming Medical University, 2018, 39(02): 71-75.

Citation:

Liu Jun Hui , Zhong Fei , Han Shao Ling , Zou Lei . A Clinical Study of Combined Therapy of Colchicine and Benzbromarone Capsules in the Treatment of Gouty Arthritis at Non-Acute Episode Stage[J]. Journal of Kunming Medical University, 2018, 39(02): 71-75.

Citation:

Liu Jun Hui , Zhong Fei , Han Shao Ling , Zou Lei . A Clinical Study of Combined Therapy of Colchicine and Benzbromarone Capsules in the Treatment of Gouty Arthritis at Non-Acute Episode Stage[J]. Journal of Kunming Medical University, 2018, 39(02): 71-75.

PDF( 226 KB)

A Clinical Study of Combined Therapy of Colchicine and Benzbromarone Capsules in the Treatment of Gouty Arthritis at Non-Acute Episode Stage

Funds:

基金：四川省科技厅科技支撑计划基金资助项目 (2014SZ0282);

Received Date: 2017-10-19

Abstract

Abstract

Objective To explore and analyze the clinical values of combined therapy of colchicine and benzbromalone capsules in the treatment of gouty arthritis of non-acute episode. Methods From December 2015 to February 2017, 60 patients with gouty arthritis who were not in acute attack were randomly divided into the combined group and the control group, with 30 cases in each group. The control group was given benzbromarone capsules and the combined group was given colchicine combined with benzbromarone capsules. The changes of laboratory indexes [blood uric acid, erythrocyte sedimentation rate (ESR) , C reactive protein (CRP) , alanine aminotransferase (ALT) , glomerular filtration rate (GFR) ], and clinical symptoms (pain, lesion joint limitation, fever, redness and tenderness) were measured and compared in the two groups before and after the treatment. The daily living ability scale (SF-36) was used to evaluate the quality of daily life before and after the treatment, and the incidence rate of drug adverse reactions during the treatment was also counted. Results No significant differences were found in the laboratory related indexes, clinical symptoms and quality of life before the treatment between the two groups (P>0.05) . After the treatment, the levels of ALT and GFR were not significantly fluctuated in the two groups, but the levels of blood uric acid, ESR, CRP, pain symptoms and quality of life were improved, and the increasing degree in the combined group was more significant than that of the control group. and the number of episodes of acute gouty arthritis in the combined group was also lower than that in the control group, and the difference between the above indexes was statistically significant (P<0.05) . The total incidence rate of adverse reactions was 30% in the combined group, which was not significantly different from that in the control group with 26.67% (χ2 = 0.180, P = 0.857) . Conclusions The use of colchicine combined with benzbromalone capsules is as the safe as the single use of benzbromalone capsules and the effect of the former one is better than that of the latter one in the treatment of gouty arthritis at non-acute episode stage.
- Colchicine,
- Benzbromarone capsules,
- Gouty arthritis at non-acute episode stage

FullText(HTML)

References(22)

References

[1]周丽丽.吲哚美辛加如意金黄散外敷治疗急性痛风性关节炎的疗效观察[J].重庆医学, 2015, 44 (7) :969-970.

[2]潘承.排酸保肾方治疗高尿酸血症及急性痛风性关节炎临床研究[J].四川中医, 2016, 34 (6) :100-102.

[3]高莹, 张治然, 汤志宏, 等.苯溴马隆联合痛风定胶囊治疗痛风性关节炎的疗效观察[J].临床军医杂志, 2015, 43 (10) :1060-1062.

[4]李建军, 王为.萆薢黄柏饮与秋水仙碱治疗痛风的疗效对比观察[J].中国中医急症, 2015, 24 (2) :317-318.

[5]中华医学会风湿病学分会.原发性痛风诊断和治疗指南[J].中华风湿病学杂志, 2011, 15 (6) :410-413.

[6]袁艳平, 李长贵.急性痛风性关节炎的规范化治疗[J].医学综述, 2014, 20 (21) :3902-3905.

[7]丁小力, 戈朝晖, 刘云宏, 等.肩关节内玻璃酸钠注射联合口服扶他林、乙哌立松治疗早期冻结肩的临床效果[J].宁夏医科大学学报, 2015, 37 (7) :845-847.

[8]刘晓波, 陈丽燕, 李爱民.探讨以SF-36量表为主要内容的生存质量评估在中医治疗类风湿关节炎疗效评价体系中的重要性[J].中国中医药信息杂志, 2016, 23 (10) :10-12.

[9]孟伟, 周陆凝, 张真瑞, 等.自拟土丹汤治疗急性痛风性关节炎及高尿酸血症疗效观察[J].四川中医, 2016, 34 (5) :110-113.

[10]袁艳平, 李长贵.痛风性关节炎患者血清白细胞介素-1β、肿瘤坏死因子-α、环氧化酶-2水平的动态变化研究[J].中华风湿病学杂志, 2013, 17 (12) :818-822.

[11]梁慧英, 廖琳, 何善智, 等.中西医结合分期治疗慢性期痛风性关节炎30例临床观察[J].中医杂志, 2015, 56 (2) :136-139.

[12]金晓畅, 郝志民, 于清欣, 等.六味痛风饮治疗痛风性关节炎60例临床观察[J].山东中医药大学学报, 2015, 39 (3) :235-237.

[13]顾雪, 张莉, 孟梅霞, 等.黄葵胶囊联合苯溴马隆治疗尿酸性肾病临床研究[J].国际中医中药杂志, 2016, 38 (9) :804-807.

[13]李爱平, 王振青.秋水仙碱联合别嘌醇治疗急性痛风性关节炎疗效分析[J].河北医学, 2014, 20 (11) :1912-1913.

[14]刘颖, 李志琛, 陈建斌, 等.小剂量秋水仙碱联合糖皮质激素治疗急性痛风性关节炎的疗效观察[J].解放军医学杂志, 2015, 40 (8) :652-655.

[15]崔炎, 王平, 张榜, 等.急性痛风性关节炎与血尿酸及尿酸盐结晶的关系[J].中国中西医结合外科杂志, 2014, 20 (5) :501-503.

[16]李育红, 张清安, 万文军, 等.秋水仙碱两种给药方案治疗痛风急性发作的临床观察[J].中国药房, 2013, 24 (28) :2642-2644.

[17]杨彦龙, 李小琴, 史静, 等.小剂量秋水仙碱联合得宝松治疗急性痛风性关节炎的疗效分析[J].检验医学与临床, 2016, 13 (15) :2103-2105.

[18]张杰, 邓文郁, 陈芍, 等.重组人Ⅱ型肿瘤坏死因子受体抗体融合蛋白联合甲氨蝶呤治疗类风湿关节炎50例临床观察[J].实用医院临床杂志, 2015, 12 (5) :180-182, 183.

[19]石玲玲, 郑佳鹏, 郭志民, 等.关节镜下碱性灌洗液治疗痛风性关节炎的实验研究[J].西部医学, 2015, 27 (8) :1138-1140.

[20]梁华玉, 王育琴.苯溴马隆肝毒性机制的研究进展[J].药物不良反应杂志, 2016, 18 (4) :286-289.

[21]柯渠青, 邱晓堂, 黄妮, 等.小剂量秋水仙碱联合依托考昔治疗急性痛风性关节炎的临床观察[J].中国医药导报, 2016, 13 (33) :129-132.

Relative Articles(20)

Relative Articles

[1]	Feifei XIE, Yinzi XIN, Min XU, Jinghan LI, Wei WANG. Mechanisms of Long Non-Coding RNAs in Cartilage Development and Related Diseases. Journal of Kunming Medical University, 2024, 45(10): 1-7. doi: 10.12259/j.issn.2095-610X.S20241001
[2]	Qing HU, Chuan LI, Chong SHI, Mo RUAN, Jingze YANG. Application Effect of A New Modified 3D PSI in Total Knee Arthroplasty for Knee Osteoarthritis. Journal of Kunming Medical University, 2024, 45(3): 84-91. doi: 10.12259/j.issn.2095-610X.S20240313
[3]	Shu-fa WEI, Jia-hui CHEN, Yi-ming LIANG, Jun-hong LIU, Yi YANG, Biao LI. Comparative Analysis of Early Efficacy of Arthroscopy Combined with Open High Tibial Osteotomy in the Treatment of Knee Osteoarthritis. Journal of Kunming Medical University, 2021, 42(12): 83-88. doi: 10.12259/j.issn.2095-610X.S20211224
[4]	Yi Nan Xing , Liang Qing Qing , Zhang Wei Qiang , Shi Qi , Wang Yong Jun , Xu Hao , Zhang Ting . Advances in Synovitis Associated with Osteoarthritis. Journal of Kunming Medical University, 2019, 40(03): 136-139.
[5]	Wang Tao , Zhang Wei Qiang , Ai Yuan Liang , Tang Xiao Xia , Guo Ying , Li Fan Bing . . Journal of Kunming Medical University, 2019, 40(01): 53-57.
[6]	Dong Wei , Yuan Xiao Lin , Li Jiao , Li Zheng Yan , Liu Wei Tong , Yu Xiao Ling , Zhang Ying . The Research of Effects of Applying Cataplasm of Paris Polyphylla Smith Var. Yunnanensis (Franch.) Hand.-Mazz on Acute Gouty Arthritis and Inflammation. Journal of Kunming Medical University, 2018, 39(02): 21-24.
[7]	Lu Yuan Yuan , Long Ting , Feng Lei , Liu Wei Chao , Li Guo Hui , Wu Lei . . Journal of Kunming Medical University, 2018, 39(11): 139-142.
[8]	Zhang Wei Qiang , Li Ju Bao , Li Fan Bing , Li Peng Fei . Effect of SCARF Osteotomy Operation of Hallux Valgus on the Stage of Knee Osteoarthritis Patients in the Lesion Side. Journal of Kunming Medical University, 2017, 38(09): 100-104.
[9]	Pan Li , Pan Bao Long , Li Jun E , Wu Ying Song . Laboratory Diagnosis and Correlation Analysis on Rheumatoid Arthritis Complicated with Coronary Heart Disease. Journal of Kunming Medical University, 2017, 38(06): 82-86.
[10]	Pan Bao Long , Wu Ling , Pan Li , Zhang Yuan Yuan , Li Jun E , Zhan Xue Liang . Application of Related Laboratory Indexes in Early Rheumatoid Arthritis. Journal of Kunming Medical University, 2017, 38(11): 96-100.
[11]	Yang Yong Qiang , Fu Chang Hong , Li Fu Bing , Yao Ling , Wan Zhi Ying , Li Jun . Application of Ilizarov External Fixator in the Arthrodesis of End-stage Complex Ankle Arthritis. Journal of Kunming Medical University, 2017, 38(07): 60-63.
[12]	Li Long Teng , Li Yan Lin , Wang Kun , Xiao Yu , Yan Xiang Jia . The Role of Singal Pathways in Osteoarthritis. Journal of Kunming Medical University, 2017, 38(04): 137-141.
[13]	Liu Hu Jun , Gao Li Ping . Influences of Different Doses of Ambroxol Hydrochloride Injection on Inflammatory Cytokines in Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease with Acute Exacerbation. Journal of Kunming Medical University, 2017, 38(09): 119-123.
[14]	Yang Zai Ying . The Effect of Osteoporosis on the Pathogenesis of Osteoarthritis. Journal of Kunming Medical University,
[15]	Hu Wei Hua . The Observation of Clinical Effect of Using Ambroxol in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Journal of Kunming Medical University,
[16]	Chang Song Jie . The Clinical Efficacy and Safety of Decreasing Blood Uric Acid by Benzene Bromine Malone in Treatment of Hyperuricemia with Elderly Hypertension and Diabetes Mellitus. Journal of Kunming Medical University,
[17]	Dai Long Jin . . Journal of Kunming Medical University,
[18]	Deng Peng Peng . . Journal of Kunming Medical University,
[19]	Yang Yang . . Journal of Kunming Medical University,
[20]	Zhang Xiao Chao . . Journal of Kunming Medical University, 2013, 34(02): 1-1.