Clinical Study on the Expression Levels of LINC02009 and LOC107984895 in Peripheral Lymphocytes of Patients with Atrial Fibrillation

Yu WANG; Rui PENG; Nini TIAN; Xiaoli ZHAO; Songqing ZHENG; Yongquan JIA; Cheng CHEN; Xueting LUAN; Wenqing MIAO; Wei HUANG

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Yu WANG, Rui PENG, Nini TIAN, Xiaoli ZHAO, Songqing ZHENG, Yongquan JIA, Cheng CHEN, Xueting LUAN, Wenqing MIAO, Wei HUANG. Clinical Study on the Expression Levels of LINC02009 and LOC107984895 in Peripheral Lymphocytes of Patients with Atrial Fibrillation[J]. Journal of Kunming Medical University.

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Clinical Study on the Expression Levels of LINC02009 and LOC107984895 in Peripheral Lymphocytes of Patients with Atrial Fibrillation

1.
Department of Cardiology
2.
Department of General Practice
3.
Department of Laboratory Medicine，The First People’s Hospital of Kunming，Kunming Yunnan 650224 ，China

Received Date: 2024-10-01
Available Online: 2025-03-09

Abstract

Abstract

Objective To investigate the expression levels of LINC02009 and LOC107984895 in peripheral lymphocytes of patients with atrial fibrillation and their clinical significance. Methods A total of 75 hospitalized patients with atrial fibrillation （50 with persistent atrial fibrillation and 25 with paroxysmal atrial fibrillation） from Kunming First People’ s Hospital between January 2023 and December 2023 were selected as study subjects, along with 50 normal control patients.Real-time quantitative PCR was used to detect the expression levels of LINC02009 and LOC107984895 in peripheral blood leukocytes of patients with atrial fibrillation. Logistic regression analysis was employed to assess the relationship between expression levels and risk factors for atrial fibrillation, and ROC curves were used to predict the diagnostic cut-off values for LINC02009 and LOC107984895 in diagnosing atrial fibrillation. Results There were statistically significant differences in baseline diseases such as hypertension and coronary heart disease, biochemical indicators such as Cr and BNP, and myocardial remodeling indicators such as LAd and LVEF between the AF （paroxysmal atrial fibrillation and persistent atrial fibrillation） group and the Normal group （P < 0.05）. The expression levels of LINC02009 and LOC107984895 in the plasma of the atrial fibrillation group were significantly higher than those in the control group （P < 0.05） and were negatively correlated with LVEF （P < 0.05）. The areas under the curve （AUC） of LINC02009 and LOC107984895 in predicting atrial fibrillation were 0.967 （95%CI: 0.938 ～ 0.995） and 0.900 （95%CI: 0.838 ～ 0.963）, respectively. The optimal cut-off values were 1.985 and 0.915, with sensitivities of 88% and 76%, respectively, and specificities of 94% and 90%, respectively. Conclusion LINC02009 and LOC107984895 are independent risk factors for atrial fibrillation and have certain predictive value for the occurrence of atrial fibrillation.
- Atrial fibrillation,
- RNA,
- Long non-coding RNA

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