Risk Factors of Cardiomyopathy in Patients with Diabetes and Their Correlations with the Levels of Serum FOXO1，GDF11 and MMP3

Shengxia ZHAO; Peipei LU; Yuan CHEN; Jinping SONG

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Shengxia ZHAO, Peipei LU, Yuan CHEN, Jinping SONG. Risk Factors of Cardiomyopathy in Patients with Diabetes and Their Correlations with the Levels of Serum FOXO1，GDF11 and MMP3[J]. Journal of Kunming Medical University.

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Risk Factors of Cardiomyopathy in Patients with Diabetes and Their Correlations with the Levels of Serum FOXO1，GDF11 and MMP3

Clinical Examination Center，People’s Hospital of Xinjiang Uygur Autonomous Region，Urumqi Xinjiang 830000，China

Received Date: 2025-06-12
Available Online: 2025-08-13

Abstract

Abstract

Objective To explore the risk factors of cardiomyopathy in patients with diabetes and their correlations with the levels of serum fork head box protein O1 （FOXO1）, growth differentiation factor 11 （GDF11）, and matrix metalloproteinase-3 （MMP3）. Methods 200 patients with diabetes complicated with cardiomyopathy and 200 patients with simple diabetes admitted to the People's Hospital of Xinjiang Uygur Autonomous Region from September 2023 to April 2025 were selected to detect serum FOXO1, GDF11 and MMP3 levels, analyze their correlation with cardiac function parameters, screen risk factors through multifactor logistic regression, construct a nomogram model and a receiver operating characteristic （ROC） curve, and evaluate the diagnostic value. Results The duration of diabetes cardiomyopathy group ≥ 10 years, the expression rate of reactive oxygen species （ROS） ≥ 90%, the insulin resistance index and the levels of FOXO1 and MMP3 were significantly higher than those in the simple diabetes group （P < 0.05）, and the level of GDF11 was lower than that in the simple diabetes group （P < 0.05）. FOXO1 and MMP3 were positively correlated with E/e 'and negatively correlated with LVEF and E/A; GDF11 was negatively correlated with E/e 'and positively correlated with LVEF and E/A （P < 0.05）. The nomogram model showed that the weights of the influencing factors were GDF11, FOXO1, insulin resistance index, MMP3, ROS expression rate, and the course of diabetes. The model calibration was good （χ²=7.336, P = 0.719）. The combined diagnostic AUC of FOXO1, GDF11, and MMP3 was 0.950, which was better than that of a single indicator （P < 0.05）. Conclusion GDF11, FOXO1, Insulin resistance index, MMP3, ROS expression rate and the course of diabetes are risk factors for diabetes cardiomyopathy, and the combination of the three is of high diagnostic value.
- Diabetes mellitus complicated with cardiomyopathy,
- Risk factors,
- FOXO1,
- GDF1,
- MMP3

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References(20)

References

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