Serum sCD276 and HE4 Levels in Ovarian Cancer Patients and Their Correlation with Postoperative Recurrence

Ruisheng XING; Hua LIU; Li GAO; Xiaobai FANG; Lei ZHAO

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Ruisheng XING, Hua LIU, Li GAO, Xiaobai FANG, Lei ZHAO. Serum sCD276 and HE4 Levels in Ovarian Cancer Patients and Their Correlation with Postoperative Recurrence[J]. Journal of Kunming Medical University.

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Ruisheng XING, Hua LIU, Li GAO, Xiaobai FANG, Lei ZHAO. Serum sCD276 and HE4 Levels in Ovarian Cancer Patients and Their Correlation with Postoperative Recurrence[J]. Journal of Kunming Medical University.

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Serum sCD276 and HE4 Levels in Ovarian Cancer Patients and Their Correlation with Postoperative Recurrence

1.
Gynecology Department，The Affiliated Hospital of Shandong Second Medical University，Weifang Shandong 261041
2.
Department of Obstetrics and Gynecology，Anqiu People’s Hospital，Anqiu Shandong 262100，China

Abstract

Abstract

Objective To investigate and analyze the correlation between serum soluble CD276 （sCD276） and human epididymis protein 4 （HE4） levels in ovarian cancer patients and postoperative recurrence. Methods A retrospective study enrolled 52 ovarian cancer patients treated at the Affiliated Hospital of Shandong Second Medical University from February 2022 to April 2023 as the study group. Additionally, 50 normal healthy subjects examined during the same period were selected as the control group. Serum levels of sCD276 and HE4 were compared, and the correlation between serum sCD276 and HE4 levels and pathological characteristics of ovarian cancer patients was determined. Patients underwent one-year postoperative follow-up and were stratified into a recurrence group （n = 12） and non-recurrence group （n = 40） based on recurrence status during follow-up. Serum sCD276 and HE4 levels were compared between the two groups. Cox regression analysis was employed to identify high-risk factors for postoperative recurrence. Receiver operating characteristic （ROC） curves were constructed to analyze the predictive value of sCD276 and HE4 for postoperative recurrence. Kaplan-Meier survival analysis was performed. Results Compared with the control group, serum sCD276 and HE4 levels were elevated in the study group. Compared with the non-recurrence group, the recurrence group showed elevated serum sCD276 and HE4 levels, as well as significant differences in tissue differentiation degree, lymph node metastasis, postoperative residual tumor diameter, carcinoembryonic antigen （CEA）, regulatory T lymphocyte （Treg） ratio, folate receptor 1 （FOLR1）, and carbohydrate antigen 125 （CA125）（P < 0.05）. Cox regression analysis identified tissue differentiation degree, lymph node metastasis, postoperative residual tumor diameter, CEA, Treg ratio, FOLR1, sCD276, and HE4 were all risk factors for postoperative recurrence in ovarian cancer. ROC curve analysis revealed that combined detection of sCD276 and HE4 had superior diagnostic efficacy compared with single-marker detection, with statistically significant differences （P < 0.05）. Kaplan-Meier survival analysis showed that patients with high levels of sCD276 and HE4 had higher mortality rates than those with low levels （P < 0.05）. Conclusion Serum sCD276 and HE4 levels are elevated in ovarian cancer patients and are associated with postoperative recurrence, making them useful for assessing postoperative recurrence status in ovarian cancer patients.
- Ovarian cancer,
- Soluble CD276,
- Human epididymal protein 4,
- Recurre

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References(20)

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