Analysis of Frailty Status and Influencing Factors in Lung Cancer Patients Undergoing Radiotherapy

Jiang ZHANG; Xijuan ZHAO; Jiang WU; Bingkun YANG; Ni YANG; Liping ZHOU

Article Contents

Article Navigation > Journal of Kunming Medical University > 2024 >

Jiang ZHANG, Xijuan ZHAO, Jiang WU, Bingkun YANG, Ni YANG, Liping ZHOU. Analysis of Frailty Status and Influencing Factors in Lung Cancer Patients Undergoing Radiotherapy[J]. Journal of Kunming Medical University.

Citation:

PDF( 633 KB)

Analysis of Frailty Status and Influencing Factors in Lung Cancer Patients Undergoing Radiotherapy

1.
Dept. of Radiotherapy，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118
2.
Dept. of Oncology，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2024-05-06
Available Online: 2024-09-04

Abstract

Abstract

Objective To investigate the current status of frailty in lung cancer patients undergoing radiotherapy and analyze its influencing factors. Methods The convenience sampling method was used to select 241 lung cancer patients admitted to the radiation therapy department of a tertiary Grade A tumor specialty hospital in Yunnan Province from January to December 2023. A questionnaire survey was conducted using the General Information Survey Questionnaire, Fried Weakness Scale, Anderson Symptom Assessment Scale （MDASI）, Hospital Anxiety and Depression Scale （SDS）, Nutrition Risk Screening 2002, and Barthel Index Scale. Results The frailty in lung cancer patients undergoing radiotherapy was 55.19%, with a total frailty score of 3.00（1.00, 4.00） points. The results of logistic regression analysis showed that age, number of radiotherapy sessions, hemoglobin count, Barthel index, Anderson symptom assessment score, and anxiety score were the influencing factors of frailty in lung cancer patients undergoing radiotherapy （P < 0.05）. Conclusion The incidence of frailties in patients with lung cancer radiotherapy is high. Age, radiotherapy frequency, hemoglobin count, Barthel index, Anderson symptom rating and anxiety score are the factors affecting frailties in patients with lung cancer radiotherapy. Clinical medical staff should promptly evaluate the frailty of lung cancer radiotherapy patients and identify their risk factors, and actively take intervention measures to prevent or control the occurrence and development of frailty.
- Lung cancer,
- Radiotherapy,
- Frailty,
- Influencing factor

FullText(HTML)

References(35)

References

[1]	Bray F,Laversanne M,Sung H,et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin,2024,74(3):229-263. doi: 10.3322/caac.21834
[2]	Nan J,Duan Y,Wu S,et al. Perspectives of older adults,caregivers,healthcare providers on frailty screening in primary care: A systematic review and qualitative meta-synthesis[J]. BMC Geriatr,2022,22(1):482. doi: 10.1186/s12877-022-03173-6
[3]	Gobbens R,Uchmanowicz I. Frailty viewed from a nursing perspective[J]. SAGE Open Nurs,2023,9: 23779608221150598.
[4]	秦莉媛,侯晓婷,杨萍. 肺癌患者症状群的研究进展[J]. 中华护理杂志,2019,54(1):119-124. doi: 10.3761/j.issn.0254-1769.2019.01.024
[5]	Li Y,Wang Q,Liu C,et al. Symptom clusters and their impact on quality of life among Chinese patients with lung cancer: A cross-sectional study[J]. Eur J Oncol Nurs,2023,67:102465. doi: 10.1016/j.ejon.2023.102465
[6]	Komici K,Bencivenga L,Navani N,et al. Frailty in patients with lung cancer: A systematic review and meta-analysis[J]. Chest,2022,162(2):485-497. doi: 10.1016/j.chest.2022.02.027
[7]	Chen K,Yang D,Li F,et al. Changes in the symptom clusters of elderly patients with lung cancer over the course of postoperative rehabilitation and their correlation with frailty and quality of life: A longitudinal study[J]. Eur J Oncol Nurs,2023,67:102388. doi: 10.1016/j.ejon.2023.102388
[8]	Dai S,Yang M,Song J,et al. Impacts of frailty on prognosis in lung cancer patients: A Systematic review and meta-Analysis[J]. Front Med (Lausanne),2021,8:715513. doi: 10.3389/fmed.2021.715513
[9]	Raghavan G,Shaverdian N,Chan S,et al. Comparing outcomes of patients with early-stage non-small-cell lung cancer treated with stereotactic body radiotherapy based on frailty status[J]. Clin Lung Cancer,2018,19(5):e759-e766. doi: 10.1016/j.cllc.2018.05.008
[10]	Ethun C G,Bilen M A,Jani A B,et al. Frailty and cancer: Implications for oncology surgery,medical oncology,and radiation oncology[J]. CA Cancer J Clin,2017,67(5):362-377. doi: 10.3322/caac.21406
[11]	Rodrigues E D,Gonsalves D,Teixeira L,et al. Frailty-the missing constraint in radiotherapy treatment planning for older adults[J]. Aging Clin Exp Res,2022,34(10):2295-2304. doi: 10.1007/s40520-022-02200-1
[12]	Güzelöz Z,Gök Balcı U. The Impact of radiotherapy on frailty in patients aged 65 and over[J]. Cureus,2023,15(10):e46351.
[13]	中华医学会肿瘤学分会,中华医学会杂志社. 中华医学会肺癌临床诊疗指南(2022版)[J]. 中华肿瘤杂志,2022,44(6):457-490. doi: 10.3760/cma.j.cn112152-20220413-00255
[14]	胡春健. 小样本下Kendall τ相关系数的显著性检验[J]. 控制工程,2013,20(6):1195-1197. doi: 10.3969/j.issn.1671-7848.2013.06.048
[15]	Fried L P,Tangen C M,Walston J,et al. Frailty in older adults: Evidence for a phenotype[J]. J Gerontol A Biol Sci Med Sci,2001,56(3):M146-156. doi: 10.1093/gerona/56.3.M146
[16]	Cleeland C S,Mendoza T R,Wang X S,et al. Assessing symptom distress in cancer patients: The M. D. Anderson symptom inventory[J]. Cancer,2000,89(7):1634-1646. doi: 10.1002/1097-0142(20001001)89:7<1634::AID-CNCR29>3.0.CO;2-V
[17]	王德生,王爱平. 安德森症状评估量表在癌症病人症状群研究中的应用[J]. 护理研究,2013,27(19):1923-1924. doi: 10.3969/j.issn.1009-6493.2013.19.002
[18]	Wondie Y,Mehnert A,Hinz A. The hospital anxiety and depression scale (HADS) applied to ethiopian cancer patients[J]. PLoS One,2020,15(12):e0243357. doi: 10.1371/journal.pone.0243357
[19]	斯彩娟,王卫光,洪秀芳,等. NRS2002、SGA在恶性肿瘤住院患者营养筛查与评估中的应用[J]. 浙江医学,2021,43(11):1192-1195. doi: 10.12056/j.issn.1006-2785.2021.43.11.2019-2659
[20]	杜春花,姜媛. 综合康复治疗对脑部恶性肿瘤患者术后Barthel指数评分及生活质量的影响[J]. 中国肿瘤临床与康复,2021,28(4):429-431.
[21]	陈菲菲,庞永慧,茅乃权,等. 老年肺癌患者衰弱现状及影响因素分析[J]. 护理学报,2020,27(15):7-11.
[22]	胡葵茹,周心玫,刘利群,等. 2016年云南省宣威市肺癌疾病负担估算[J]. 中国肿瘤,2021,30(2):137-143. doi: 10.11735/j.issn.1004-0242.2021.02.A006
[23]	Tree A C,Ostler P,van der Voet H,et al. Intensity-modulated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): 2-year toxicity results from An open-label,randomised,phase 3,non-inferiority trial[J]. Lancet Oncol,2022,23(10):1308-1320. doi: 10.1016/S1470-2045(22)00517-4
[24]	Imam T,Konstant-Hambling R,Fluck R,et al. The hospital frailty risk score-outcomes in specialised services[J]. Age Ageing,2021,50(2):511-518. doi: 10.1093/ageing/afaa156
[25]	Hou Y G,Feng S M,Wang S M,et al. The construction and validation of a frailty risk prediction model for older adults with lung cancer: A cross-sectional study[J]. Eur J Oncol Nurs,2023,64:102316. doi: 10.1016/j.ejon.2023.102316
[26]	Rodr í guez-G ó mez I,Mañas A,Losa-Reyna J,et al. Prospective changes in the distribution of movement behaviors are associated with bone health in the elderly according to variations in their frailty levels[J]. J Bone Miner Res,2020,35(7):1236-1245. doi: 10.1002/jbmr.3988
[27]	Brush J,Lipnick S L,Phillips T,et al. Molecular mechanisms of late normal tissue injury[J]. Semin Radiat Oncol,2007,17(2):121-130. doi: 10.1016/j.semradonc.2006.11.008
[28]	汪燃,黄菲. 中老年肺癌患者胸部放疗期间症状群的调查及护理对策[J]. 中华护理杂志,2023,58(13):1596-1602. doi: 10.3761/j.issn.0254-1769.2023.13.010
[29]	张江,吴江,赵喜娟,等. 集束化护理对鼻咽癌放疗患者口腔黏膜炎及张口受限的影响[J]. 昆明医科大学学报,2021,42(5):170-175. doi: 10.12259/j.issn.2095-610X.S20210531
[30]	Ruan Y,Guo Y,Kowal P,et al. Association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in China[J]. BMC Geriatr,2019,19(1):327. doi: 10.1186/s12877-019-1342-5
[31]	Jiang N,Chen X C,Zhao Y. Analysis of the risk factors for myelosuppression after concurrent chemoradiotherapy for patients with advanced non-small cell lung cancer[J]. Support Care Cancer,2013,21(3):785-791. doi: 10.1007/s00520-012-1580-y
[32]	Loewenthal J,Berning M J,Wayne P M,et al. Holistic frailty prevention: The promise of movement-based mind-body therapies[J]. Aging Cell,2024,23(1):e13986. doi: 10.1111/acel.13986
[33]	Dent E ,Martin F C ,Bergman H ,et al. Management of frailty: Opportunities,challenges,and future directions[J]. The Lancet,2019,394(10206): 1376-1386.
[34]	Wan D,Wang R,Wei J,et al. Translation and validation of the Chinese version of the Japan frailty scale[J]. Front Med (Lausanne),2023,10:1257223. doi: 10.3389/fmed.2023.1257223
[35]	Gill T M,Baker D I,Gottschalk M,et al. A program to prevent functional decline in physically frail,elderly persons who live at home[J]. N Engl J Med,2002,347(14):1068-1074. doi: 10.1056/NEJMoa020423

Relative Articles(20)

Relative Articles

[1]	Ying WANG, Cong FU, Ying FU. Clinical Implications of Serum LDH，CysC，and PWR Level Detection in Lung Cancer Patients. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20240424
[2]	Xuesong HU, Wenbin DONG, Shifu LI, Liyue CHEN, Yingzhou MIAO, Bing SHEN, WenRui ZHOU, Shaoxing DONG. Frailty and Related Factors in Elderly Patients with Chronic Pain. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20241020
[3]	Yajie SAI, Lvxin YAO, Ling CHENG, Li SHEN, Cailian QI, Zhaoxia WANG, Huatao NIU. Correlation Analysis between the Caregiver Burden and Life Meaning in Patients with the Early Diagnosis of Lung Cancer. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20230906
[4]	Jiang WU, Shuifen DAI, Qin LIU, Shoutao YANG, Jiang ZHANG, Jiao YANG, Qiongyao GUAN. Effect of Nutrition Clinical Nursing Pathway for Nasopharyngeal Carcinoma Patients Concurrent Radiotherapy and Chemotherapy. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20230510
[5]	Yongchang LV, Wei LUO, Xugang ZHANG, Ran CAO, Ziqiang LI, Rong WANG, Qiying ZHENG, Yuekun LIU, Tingyan LIU, Jili YIN, Peipei DING, Kun WANG. Effect of Combined Intervention of Thoracic Surgery and Rehabilitation Department on Fast Track Surgery of Patients after Uniportal Video-assisted Thoracoscopic Surgery. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20221013
[6]	Yanyan FEI, Yangshan FU, Bingkun YANG, Lijuan LI, Shuifen DAI, Jiang WU, Qin LIU. Needs Assessment of Health Education for Dysphagia in Nasopharyngeal Carcinoma Radiotherapy Patients Based on KANO Model. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20220829
[7]	Yuxiao XIA, Xiuli FENG, Wei GUO, Shanjiao ZHONG, Yu DING, Manman DONG, Xuewei YANG, Ying ZHOU. Comparison of Frailty Assessment Methods for Predicting Postoperative Complications in Hospitalized Elderly Patients. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20220723
[8]	Ming-jie NING, Ying CHEN. Research Progress of The Correlation between Lung Microbiome and Lung Cancer. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210336
[9]	Chang LIU, Zhen-hua LI, Ying WANG, Yan-qin RUAN, Lai-hao QU, Ding-biao LI. Applications of Lung Cancer MDT Combined with PBL + CBL Model in the Clinical Teaching. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210911
[10]	Jiang ZHANG, Xi-juan ZHAO, Jiang WU, Yan LIU, Li-juan LI, Ye CHEN. Application of Family Empowerment Nursing Intervention Program in Patients with Lung Cancer Undergoing Radiotherapy. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20211242
[11]	Jiang WU, Yan-yan FEI, Shui-fen DAI, Li YANG, Qian ZHOU, Ling ZHANG, Tao SHI. Effect of Standard Nutrition Intervention on Quality of Life in Patients with Rhinitis after Radiotherapy. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210728
[12]	Zhao Min , Bi Jun Qiang , Zhou Yong Chun , Zhang Jin Ping , Luo Lei . Characteristics and Trends of Disease Constitution of 9553 Inpatients with Lung Cancer in Yunnan Province. Journal of Kunming Medical University,
[13]	Fan Min Juan , Zhong Yun Hua , Shen Wen , Yuan Kai Fen , Zhao Guo Hou , Wang Shu Kun , Wen Lin Qiao . HSF2 Promotes Heat Shock Protein Expression in Lung Cancer. Journal of Kunming Medical University,
[14]	Wang Hong . Role of Prostaglandin E2 in the Pathogenesis of COPD with Lung Cancer. Journal of Kunming Medical University,
[15]	Lu Xi Wei . Clinical Effects of Cisplatin Combined with Temozolomide and Radiotherapy in Treatment of Glioblastomas after Surgery. Journal of Kunming Medical University,
[16]	Pan Long Fang . . Journal of Kunming Medical University,
[17]	Ma Jian Qiang . . Journal of Kunming Medical University,
[18]	Chen Jin Run . . Journal of Kunming Medical University,
[19]	Shi Lei . . Journal of Kunming Medical University,
[20]	. . Journal of Kunming Medical University,