Diagnostic Value of Ultrasonography Combined with Serum IL-1β And CYFRA21-1 in Ovarian Cancer

Shuwei WANG; Yuli ZHANG; Heli LIU; Jie SU

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Shuwei WANG, Yuli ZHANG, Heli LIU, Jie SU. Diagnostic Value of Ultrasonography Combined with Serum IL-1β And CYFRA21-1 in Ovarian Cancer[J]. Journal of Kunming Medical University.

Citation:

Shuwei WANG, Yuli ZHANG, Heli LIU, Jie SU. Diagnostic Value of Ultrasonography Combined with Serum IL-1β And CYFRA21-1 in Ovarian Cancer[J]. Journal of Kunming Medical University.

Shuwei WANG, Yuli ZHANG, Heli LIU, Jie SU. Diagnostic Value of Ultrasonography Combined with Serum IL-1β And CYFRA21-1 in Ovarian Cancer[J]. Journal of Kunming Medical University.

Citation:

Shuwei WANG, Yuli ZHANG, Heli LIU, Jie SU. Diagnostic Value of Ultrasonography Combined with Serum IL-1β And CYFRA21-1 in Ovarian Cancer[J]. Journal of Kunming Medical University.

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Diagnostic Value of Ultrasonography Combined with Serum IL-1β And CYFRA21-1 in Ovarian Cancer

1.
Department of Ultrasound
2.
Department of Gynecology，Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine in Hebei Province，Cangzhou Hebei 061001，China

Abstract

Abstract

Objective To explore the diagnostic value of ultrasound combined with serum interleukin-1β （IL-1β） and cytokeratin 19 fragment antigen 21-1 （CYFRA21-1） in ovarian cancer. Methods From July 2020 to July 2023, 250 patients with ovarian tumors admitted to Cangzhou Integrated Chinese and Western Medicine Hospital were enrolled. Among them, 114 patients confirmed as having ovarian cancer by pathological examination comprised the ovarian cancer group. Additionally, 114 patients were randomly selected from the remaining 136 patients with benign tumors to form the control group. All study subjects underwent diagnosis using color ultrasound diagnostic equipment. Serum levels of IL-1β and CYFRA21-1 were detected using the enzyme linked immunosorbent assay （ELISA） method. Kappa test was used to analyze the consistency between diagnostic methods and surgical pathological results. Multivariate logistic regression analysis was performed to identify risk factors for ovarian cancer occurrence. Receiver operating characteristic （ROC） curve analysis was used to evaluate the diagnostic value of ultrasound combined with serum IL-1β and CYFRA21-1 for ovarian cancer. Results Serum levels of IL-1β and CYFRA21-1 in the ovarian cancer group were significantly elevated compared to the control group （P < 0.05）. Compared with clear cell carcinoma, serum levels of IL-1β and CYFRA21-1 in patients with mucinous adenocarcinoma and serous adenocarcinoma were significantly elevated （P < 0.05）. Serum levels of IL-1β and CYFRA21-1 in ovarian cancer patients showed a progressive increase across stages I<stage II<stage III<stage IV （P < 0.05）. Elevated serum levels of IL-1 β and CYFRA21-1 were risk factors for ovarian cancer （P < 0.05）. The area under the curve （AUC） for the combined ultrasound with serum IL-1β and CYFRA21-1 in diagnosing ovarian cancer was significantly higher than the AUC values of single-indicator diagnosis （Z_{ultrasound～ultrasound+IL-1β+CYFRA21-1}=3.782, P < 0.001; Z_{IL-1β～ultrasound+IL-1β+CYFRA21-1}=4.046, P < 0.001; Z_{CYFRA21-1～ultrasound+IL-1β+CYFRA21-1}=7.279, P < 0.001）. Based on pathological examination results, the consistency of combined diagnosis （Kappa value=0.789） was higher than ultrasound alone （Kappa value=0.658）. Conclusion : The combined diagnostic approach of ultrasound with serum IL-1β and CYFRA21-1 demonstrates high diagnostic efficacy for ovarian cancer and has certain clinical significance.
- Ultrasound,
- Interleukin-1β,
- Cytokeratin 19 fragment antigen 21-1,
- Ovarian cancer,
- Diagnosis

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References(21)

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