Diagnostic value of adenosine stress-resting gated myocardial perfusion imaging in the diagnosis of three-vessel coronary heart disease

Liju HONG; Feipeng WU; Qiyan WU; Xiandong ZHENG; Rui YANG; Dandan CHEN; Youjun ZHOU

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Liju HONG, Feipeng WU, Qiyan WU, Xiandong ZHENG, Rui YANG, Dandan CHEN, Youjun ZHOU. Diagnostic value of adenosine stress-resting gated myocardial perfusion imaging in the diagnosis of three-vessel coronary heart disease[J]. Journal of Kunming Medical University.

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Diagnostic value of adenosine stress-resting gated myocardial perfusion imaging in the diagnosis of three-vessel coronary heart disease

Department of Nuclear Medicine，Yan’an Hospital Affiliated to Kunming Medical University，Kunming Yunnan 650051，China

Received Date: 2024-09-15
Available Online: 2025-02-18

Abstract

Abstract

Objective To evaluate the diagnostic value of adenosine load - resting gated myocardial perfusion imaging for three-vessel disease in coronary artery disease （CAD） patients using coronary angiography as the gold standard. Methods A retrospective study was conducted, including 318 patients diagnosed with CAD who underwent coronary angiography at Yanan Hospital Affiliated to Kunming Medical University from January 2021 to December 2022. Based on the results of coronary angiography, the 318 CAD patients were divided into a three-vessel disease group （n = 166） and a non-three-vessel disease group （single and double vessel disease group, n = 152）. All the subjects underwent adenosine stress-resting GMPI within two weeks. Adenosine stress-resting GMPI myocardial perfusion parameters （SSS, SRS, SDS）, cardiac function parameters （LVEF, LVEDV, LVSV） and left ventricular mechanical contraction synchronization parameters （PSD, PHB） were collected. The diagnostic value of adenosine stress - resting gated myocardial perfusion imaging for three-vessel disease in CAD was explored. Results Among the perfusion parameters, SSS had the highest AUC of 0.781, while sLVEF had the highest AUC of 0.748 among cardiac function parameters, and sPHB had the highest AUC of 0.724 among synchrony parameters. The AUCs of combined parameters were all higher than those of perfusion parameters, cardiac function parameters, and synchrony parameters （P < 0.05）. The changes in ΔLVESV and ΔLVEF between the three- vessel disease group and the non-three vessel disease group showed statistical significance （P < 0.05）. Conclusion The perfusion, cardiac function and synchronization parameters of adenosine stress-resting gated myocardial perfusion imaging have high diagnostic value for three-vessel coronary heart disease, and the combined detection of the three parameters provides even greater diagnostic value for three-vessel coronary heart disease.
- Adenosine,
- Stress-gated myocardial perfusion imaging,
- Coronary heart disease,
- Three-vessel disease

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[1]	胡盛寿,高润霖,刘力生,等. 《中国心血管病报告2018》概要[J]. 中国循环杂志,2019,34(3):209-220. doi: 10.3969/j.issn.1000-3614.2019.03.001
[2]	Jie L,Feng X X,Duan Y F,et al. Using machine learning to aid treatment decision and risk assessment for severe three-vessel coronary artery disease[J]. J Geriatr Cardiol,2022,19(5):367-376.
[3]	Glazier J J,Ramos-Parra B,Kaki A. Therapeutic Options for Left Main,Left Main Equivalent,and Three-Vessel Disease[J]. International Journal of Angiology,2021,30(1):76-82. doi: 10.1055/s-0041-1723977
[4]	Sirajuddin A,Mirmomen S M,Kligerman S J,et al. Ischemic Heart Disease: Noninvasive Imaging Techniques and Findings[J]. Radiographics,2021,41(4):990-1021. doi: 10.1148/rg.2021200125
[5]	Knuuti J,Wijns W,Saraste A,et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes[J]. Eur Heart J,2020,41(3):407-477. doi: 10.1093/eurheartj/ehz425
[6]	Society of Nuclear Medicine of Chinese Medical A,Society of Cardiology of Chinese Medical A. [Guideline for the clinical use of myocardial radionuclide imaging (2018)][J]. Zhonghua Xin Xue Guan Bing Za Zhi,2019,47(7):519-527.
[7]	Schlattmann P,Wieske V,Bressem K K,et al. The effectiveness of coronary computed tomography angiography and functional testing for the diagnosis of obstructive coronary artery disease: Results from the individual patient data Collaborative Meta-Analysis of Cardiac CT (COME-CCT)[J]. Insights Imaging,2024,15(1):208. doi: 10.1186/s13244-024-01702-y
[8]	Gulati M,Levy P D,Mukherjee D,et al. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines [J]. Circulation,2021,144(22):455.
[9]	Herner M,Agasthi P. Cardiac Stress Imaging [M]. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Pradyumna Agasthi declares no relevant financial relationships with ineligible companies. ; StatPearls Publishing Copyright © 2024,StatPearls Publishing LLC. 2024.
[10]	Gopal S,Murphy C. Nuclear Medicine Stress Test [M]. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Christie Murphy declares no relevant financial relationships with ineligible companies. ; StatPearls Publishing Copyright © 2024,StatPearls Publishing LLC. 2024.
[11]	中华医学会核医学分会,中华医学会心血管病学分会. 核素心肌显像临床应用指南(2018)[J]. 中华心血管病杂志,2019,47(7):519-527.
[12]	中华医学会心血管病学分会介入心脏病学组,中华医学会心血管病学分会动脉粥样硬化与冠心病学组,中国医师协会心血管内科医师分会血栓防治专业委员会,et al. 稳定性冠心病诊断与治疗指南[J]. 中华心血管病杂志,2018,46(9):680-694.
[13]	Neumann F J,Sousa-Uva M,Ahlsson A,et al. 2018 ESC/EACTS Guidelines on myocardial revascularization[J]. Eur Heart J,2019,40(2):87-165. doi: 10.1093/eurheartj/ehy394
[14]	中华医学会心血管病学分会介入心脏病学组,中国医师协会心血管内科医师分会血栓防治专业委员会,中华心血管病杂志编辑委员会. 中国经皮冠状动脉介入治疗指南(2016)[J]. 中华心血管病杂志,2016,44(5):382-400.
[15]	Bax J J,Achenbach S,Valgimigli M,et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes[J]. European Heart Journal,2020,41(3):407-477. doi: 10.1093/eurheartj/ehz425
[16]	Garcia-Cardenas M,Espejel-Guzman A,Antonio-Villa N E,et al. Diagnosis,performance and added value of assessing ventricular dyssynchrony by phase analysis in patients with three-vessel disease: A single-center cross-sectional study in Mexico[J]. J Nucl Cardiol,2023,30(3):1219-1229. doi: 10.1007/s12350-022-03136-9
[17]	Gimelli A,Liga R,Duce V,et al. Accuracy of myocardial perfusion imaging in detecting multivessel coronary artery disease: A cardiac CZT study[J]. J Nucl Cardiol,2017,24(2):687-695. doi: 10.1007/s12350-015-0360-8
[18]	Hida S,Chikamori T,Tanaka H,et al. Diagnostic value of left ventricular dyssynchrony after exercise and at rest in the detection of multivessel coronary artery disease on single-photon emission computed tomography[J]. Circ J,2012,76(8):1942-1952. doi: 10.1253/circj.CJ-11-1392
[19]	Patel J J,Alzahrani T. Myocardial Perfusion Scan [M]. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Talal Alzahrani declares no relevant financial relationships with ineligible companies. StatPearls Publishing Copyright © 2024,StatPearls Publishing LLC. 2024.
[20]	Alexánderson-Rosas E,Hernández-Sandoval S. Gated SPECT beyond myocardial perfusion: Assessment of mechanical left ventricular synchrony[J]. J Nucl Cardiol,2022,29(3):975-977. doi: 10.1007/s12350-020-02518-1
[21]	Khidir M J,Delgado V,Ajmone Marsan N,et al. Mechanical dyssynchrony in patients with heart failure and reduced ejection fraction: How to measure?[J]. Curr Opin Cardiol,2016,31(5):523-530. doi: 10.1097/HCO.0000000000000314
[22]	Lima R S L,Watson D D,Goode A R,et al. Incremental value of combined perfusion and function over perfusion alone by gated SPECT myocardial perfusion imaging for detection of severe three-vessel coronary artery disease[J]. Journal of the American College of Cardiology,2003,42(1):64-70. doi: 10.1016/S0735-1097(03)00562-X
[23]	Camilletti J,Erriest J,Espinola-Zavaleta N,et al. Left ventricular dyssynchrony and abnormalities in wall motion,assessed by gated-SPECT as ischemic auxiliary markers[J]. Journal of Nuclear Cardiology,2018,27(6):2261-2268.

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