Expression Levels of Serum RAGE and CXCL10 in Children with Bronchiolitis and Their Correlation with Disease Severity

Weina WANG; Wenlu HAN; Yun DU; Shuai GAO

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Weina WANG, Wenlu HAN, Yun DU, Shuai GAO. Expression Levels of Serum RAGE and CXCL10 in Children with Bronchiolitis and Their Correlation with Disease Severity[J]. Journal of Kunming Medical University.

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Weina WANG, Wenlu HAN, Yun DU, Shuai GAO. Expression Levels of Serum RAGE and CXCL10 in Children with Bronchiolitis and Their Correlation with Disease Severity[J]. Journal of Kunming Medical University.

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Expression Levels of Serum RAGE and CXCL10 in Children with Bronchiolitis and Their Correlation with Disease Severity

Department of Clinical Laboratory，Zhangjiakou Maternity and Child Health Hospital，Zhangjiakou Hebei 075000，China

Received Date: 2026-01-14

Abstract

Abstract

Objective To explore the relationship between serum levels of receptor for advanced glycation end product （RAGE） and CXC chemokine ligand 10 （CXCL10） and disease severity in children with bronchiolitis. Methods A total of 102 children with bronchiolitis admitted to Zhangjiakou Maternal and Child Health Hospital from January 2023 to July 2024 were enrolled and stratified by disease severity into mild group （n = 39）, moderate group （n = 31）, and severe group （n = 32）. Ninety healthy children from routine physical examinations at the same hospital during the same period served as controls. Clinical data including age and sex were collected for each group. T-test, χ²test, or one-way ANOVA were used to compare clinical characteristics and serum RAGE and CXCL10 levels among groups. Spearman correlation analysis was conducted to determine correlation, logistic regression analysis was used to identify influencing factors, and ROC curve analysis to assess predictive value. Results Serum RAGE and CXCL10 levels in children with bronchiolitis were significantly higher than those in the control group （t = 10.518, 9.631, P < 0.05）. There was a statistically significant difference in premature birth rate among children with mild, moderate, and severe bronchiolitis （χ² = 11.226, P < 0.05）. With increasing disease severity, neutrophil percentage, neutrophil/lymphocyte ratio, serum RAGE and CXCL10 levels progressively increased （F/χ²=7.883, 14.749, 30.808, 16.483, P < 0.05）, while lymphocyte percentage progressively decreased （χ²=13.938, P < 0.05）. Serum RAGE and CXCL10 levels were positively correlated with disease severity （r = 0.699, 0.485, P < 0.05）. Elevated serum RAGE and CXCL10 levels were independent risk factors for disease severity（OR = 1.726, 1.761, P < 0.05）. The risk of moderate/severe disease in patients with high serum RAGE and CXCL10 levels was 1.900-fold （95%CI 1.250-2.887） and 1.613-fold （95%CI 1.108-2.347） higher than in those with low levels, respectively. The combined AUC of serum RAGE and CXCL10 for predicting disease severity was 0.951, superior to single biomarker assessment （Z_{RAGE -combination} =2.084, P = 0.037, Z_{CXCL10 -combination} =2.738, P = 0.006）. Conclusion Serum RAGE and CXCL10 levels are elevated in children with bronchiolitis and are risk factors for disease severity. Combined assessment of both biomarkers has superior clinical predictive value.
- Bronchiolitis,
- Severity of disease,
- Receptor for advanced glycation end product,
- CXC chemokine ligand 10

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References(24)

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