Chemical Composition and Biological Activity of <i>Dendrobium primulinum</i>

Runqi GU; Qinchang LIAO; Ying ZHOU; Canyu HE; Yaqi ZHAO; Chenxi ZHUANG; Yupeng LI

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Runqi GU, Qinchang LIAO, Ying ZHOU, Canyu HE, Yaqi ZHAO, Chenxi ZHUANG, Yupeng LI. Chemical Composition and Biological Activity of Dendrobium primulinum[J]. Journal of Kunming Medical University.

Citation:

Runqi GU, Qinchang LIAO, Ying ZHOU, Canyu HE, Yaqi ZHAO, Chenxi ZHUANG, Yupeng LI. Chemical Composition and Biological Activity of Dendrobium primulinum[J]. Journal of Kunming Medical University.

Runqi GU, Qinchang LIAO, Ying ZHOU, Canyu HE, Yaqi ZHAO, Chenxi ZHUANG, Yupeng LI. Chemical Composition and Biological Activity of Dendrobium primulinum[J]. Journal of Kunming Medical University.

Citation:

Runqi GU, Qinchang LIAO, Ying ZHOU, Canyu HE, Yaqi ZHAO, Chenxi ZHUANG, Yupeng LI. Chemical Composition and Biological Activity of Dendrobium primulinum[J]. Journal of Kunming Medical University.

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Chemical Composition and Biological Activity of Dendrobium primulinum

Runqi GU^{1, 2},
Qinchang LIAO³,
Ying ZHOU³,
Canyu HE^{1, 2},
Yaqi ZHAO^{1, 2},
Chenxi ZHUANG^{1, 2, 4
,
,},
Yupeng LI^{1, 2
,
,}

1.
School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural
2.
School of Modern Biomedicine Industry，Kunming Medical University，KunmingYunnan 650500
3.
Institute of Caulis Dendrobii of Longling County，Baoshan Yunnan 678300
4.
School of Pharmacy，Honghe Health Vocational College，Honghe Yunnan 661100，China

Received Date: 2024-09-02
Available Online: 2025-02-18

Abstract

Abstract

Objective To study the chemical composition of and identify its active components. Methods The chemical constituents of were extracted using solvents, followed by separation through silica gel and gel column chromatography, with structural identification performed via spectral analysis. The in vitro activity screening of some compounds was conducted using the MTT assay. Results Seven compounds were isolated and identified from Dendrobium primulinum, namely 7-dihydroxy-2, 4-methoxyphenanthrene（1）, densiflorol B （2）, 3, 4, 7-trihydroxy-2-methoxy-9, 10-dihydrophenanthrene （3）, thunalbene （4）, phillygenin （5）, 3β-hydroxy-5α, 8α-epidioxyergosta-6, 22-diene （6）、4-hydroxy-3, 5-dimethoxy--cinnamaldehyde （7） . Antitumor activity tests were performed on compounds 1 to 5, revealing that compound 1 exhibited strong inhibitory activity against the MCF-7/S cell line, with an IC50 of 5.13 μM. Conclusion Compounds 1 to 6 are reported for the first time from Dendrobium primulinum, while compound 7 is reported for the first time from this genus.
- Dendrobium primulinum,
- Chemical constituents,
- Bioactive activity

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References(15)

References

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