Effect of Azithromycin Sequential Therapy Combined with Methylprednisolone on Pulmonary Function Indices and Immune Indices in Children with Severe Mycoplasma Pneumonia

Lan LIU; Xuejun ZHAO; Hongju FANG

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Lan LIU, Xuejun ZHAO, Hongju FANG. Effect of Azithromycin Sequential Therapy Combined with Methylprednisolone on Pulmonary Function Indices and Immune Indices in Children with Severe Mycoplasma Pneumonia[J]. Journal of Kunming Medical University.

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Effect of Azithromycin Sequential Therapy Combined with Methylprednisolone on Pulmonary Function Indices and Immune Indices in Children with Severe Mycoplasma Pneumonia

Department of Pediatrics，Youxian District Maternal and Child Health Hospital，Mianyang Sichuan 621000，China

Received Date: 2026-03-02
Available Online: 2026-10-29

Abstract

Abstract

Objective To investigate the effects of azithromycin sequential therapy combined with methylprednisolone on pulmonary function indices and immune indices in children with severe Mycoplasma pneumonia. Methods A retrospective analysis was conducted on the clinical data of 150 children with severe Mycoplasma pneumoniae pneumonia admitted to a certain hospital from January 2023 to June 2025. According to different treatment modalities, they were divided into a study group（n = 75, treated with azithromycin sequential therapy combined with methylprednisolone） and a control group（n = 75, treated with azithromycin sequential therapy） .The clinical efficacy, inflammatory factors, pulmonary function indices, immune indices, and adverse reactions of the two groups were compared. Results After treatment, the clinical pulmonary infection score, levels of interleukin-6, procalcitonin, soluble programmed death receptor ligand 1, and high-sensitivity C-reactive protein, as well as chest imaging score and airway mucosal inflammation score in the study group were all lower than those in the control group （P < 0.05）. The maximum voluntary ventilation, forced expiratory volume in the first second, peak expiratory flow, forced vital capacity, forced expiratory flow at 75% of vital capacity, forced expiratory flow at 50% of vital capacity, and levels of immunoglobulin A, immunoglobulin G, complement C3, and complement C4 were all higher than those in the control group, and the duration of fever, cough, sputum production, and moist rales were shorter than those of the control group （P < 0.05）; After treatment, there was no statistically significant difference in the total incidence of adverse reactions between the two groups （P > 0.05）. Conclusion Azithromycin sequential therapy combined with methylprednisolone can improve the levels of inflammatory factors and pulmonary function indices, regulate immunity, and enhance therapeutic efficacy in children with severe Mycoplasma pneumoniae pneumonia, with a certain level of safety.
- Azithromycin,
- Methylprednisolone,
- Severe Mycoplasma pneumoniae pneumonia in children

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References(25)

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