The Relationship between PBEF，KLF2，IL-26 and The Condition and Prognosis of Severe Pneumonia in Children

Yan ZHANG; Yun TANG

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Yan ZHANG, Yun TANG. The Relationship between PBEF，KLF2，IL-26 and The Condition and Prognosis of Severe Pneumonia in Children[J]. Journal of Kunming Medical University.

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Yan ZHANG, Yun TANG. The Relationship between PBEF，KLF2，IL-26 and The Condition and Prognosis of Severe Pneumonia in Children[J]. Journal of Kunming Medical University.

Yan ZHANG, Yun TANG. The Relationship between PBEF，KLF2，IL-26 and The Condition and Prognosis of Severe Pneumonia in Children[J]. Journal of Kunming Medical University.

Citation:

Yan ZHANG, Yun TANG. The Relationship between PBEF，KLF2，IL-26 and The Condition and Prognosis of Severe Pneumonia in Children[J]. Journal of Kunming Medical University.

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The Relationship between PBEF，KLF2，IL-26 and The Condition and Prognosis of Severe Pneumonia in Children

Yan ZHANG,
Yun TANG^,

Department of General Internal Medicine，Xi’an Children’s Hospital，Xi’an Shaanxi 710003，China

Received Date: 2025-06-16

Abstract

Abstract

Objective To discuss the relationship between serum pre-B cell colony-enhancing factor （PBEF）, Kruppel like factor 2 （KLF2）, interleukin-26 （IL-26） and the severity and prognosis of severe pneumonia （SP） in children. Methods A total of 180 children with SP admitted to Xi 'an Children's Hospital from March 2023 to March 2025 were selected as the research subjects. The protein levels of PBEF, KLF2 and IL-26 in serum were detected respectively using ELISA kits. The severity of the children's conditions was determined based on the acute physiology and chronic health score Ⅱ （APACHE Ⅱ score）, and they were grouped into the non-critical group （n = 60）, the critical group （n = 75）, and the extremely critical group （n = 45）. According to the prognosis of children with SP, they were divided into the good prognosis group （n = 127） and the poor prognosis group （n = 53）. The correlations between the levels of serum PBEF, KLF2 and IL-26 and the APACHE Ⅱ score were analyzed by the Pearson method. Multivariate logistic regression analysis was conducted to analyze the factors influencing the prognosis and outcome of children with SP. ROC curve was used to analyze the predictive value of serum PBEF, KLF2 and IL-26 levels for the prognosis and outcome of children with SP. Results Compared with the non-critical group, the APACHE Ⅱ score, serum PBEF and IL-26 levels in the critical group and the extremely critical group were all increased （P < 0.05）, and the serum KLF2 level was all decreased （P < 0.05）. Compared with the critical group, the APACHE Ⅱ score and the levels of serum PBEF and IL-26 in the extremely critical group were increased, while the level of serum KLF2 was decreased （P < 0.05）. The levels of serum PBEF and IL-26 in children with SP were positively correlated with the APACHE Ⅱ score, while the level of serum KLF2 was negatively correlated with the APACHE Ⅱ score （P < 0.05）. The proportion of extremely critical patients, APACHE Ⅱ score, serum PBEF and IL-26 levels in the poor prognosis group were increased compared with those in the good prognosis group, while the serum KLF2 level was decreased （P < 0.05）. The elevated levels of serum PBEF and IL-26 and the decreased level of KLF2 are risk factors for poor prognosis in children with SP （P < 0.05）. The AUCs of serum PBEF, KLF2, and IL-26 levels alone and in combination for predicting poor prognosis in children were 0.769, 0.820, 0.814, and 0.933, respectively. The combined predictive value of the three was higher （Z=4.112, 3.893, 4.035, all P < 0.001）. Conclusion With the increase of the severity of the disease in children with SP, the levels of serum PBEF and IL-26 were increased, and the level of KLF2 was decreased. The three can be used as indicators for predicting the prognosis and outcome of children.
- Severe pneumonia,
- Pre-B cell colony-enhancing factor,
- Kruppel like factor 2,
- Interleukin-26,
- Severity of disease,
- Prognostic outcomes

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