The Mechanism of Protein Lactylation Modification in Sepsis Organ Dysfunction

Couwen LI; Bing GONG; Runfei SHAO; Zhuange SHI; Lishun YANG; Guobing CHEN

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Couwen LI, Bing GONG, Runfei SHAO, Zhuange SHI, Lishun YANG, Guobing CHEN. The Mechanism of Protein Lactylation Modification in Sepsis Organ Dysfunction[J]. Journal of Kunming Medical University.

Citation:

Couwen LI, Bing GONG, Runfei SHAO, Zhuange SHI, Lishun YANG, Guobing CHEN. The Mechanism of Protein Lactylation Modification in Sepsis Organ Dysfunction[J]. Journal of Kunming Medical University.

Couwen LI, Bing GONG, Runfei SHAO, Zhuange SHI, Lishun YANG, Guobing CHEN. The Mechanism of Protein Lactylation Modification in Sepsis Organ Dysfunction[J]. Journal of Kunming Medical University.

Citation:

Couwen LI, Bing GONG, Runfei SHAO, Zhuange SHI, Lishun YANG, Guobing CHEN. The Mechanism of Protein Lactylation Modification in Sepsis Organ Dysfunction[J]. Journal of Kunming Medical University.

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The Mechanism of Protein Lactylation Modification in Sepsis Organ Dysfunction

1.
Graduate School of Kunming University of Science and Technology，Kunming Yunnan 650500
2.
Department of Emergency，Yunnan First People’s Hospital，Kunming Yunnan 650032，China

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Corresponding author: 陈国兵，博士，主任医师，博士研究生导师，云南省第一人民医院医务处处长、急诊医学学科带头人，云南省中青年学术技术带头人、云南省兴滇英才医疗卫生人才、云南省医学高端人才，曾担任英国苏塞克斯大学附属医院访问学者。在学术科研领域，主持国家自然科学基金 2 项、省部级课题 15 项；近 5 年发表 SCI 论文 9 篇（累计影响因子 49.76 分）、中文核心期刊论文 9 篇。培养硕士研究生 14 人、博士研究生 2 人。于 2020 年 11 月获九三学社新冠肺炎疫情防控全国先进个人，2021 年 6 月获云南省省级卫生健康系统 “优秀共产党员” 称号。兼任中国医药教育协会蛇伤防治专业委员会副主任委员，云南省急诊医学质控中心副主任委员，云南省医学会急诊医学分会常委、呼吸支持学组组长，云南省医学会重症医学分会重症康复学组副组长、青年委员会委员，以及云南省医师协会体外生命支持专业委员会常委、老年重症医师分会委员、重症医师分会委员。
Received Date: 2025-06-17
Available Online: 2025-08-13

Abstract

Abstract

This article aims to explore the mechanism of protein lactate modification （Kla） in sepsis and multiple organ dysfunction syndrome （MODS）. By regulating gene transcription and inflammatory factor expression, Kla participates in sepsis organ function damage, and can also destroy the cell structure and metabolic homeostasis, aggravating sepsis induced lung, kidney, heart, brain, liver organ damage. By conducting in-depth study on its mechanism, it will help to explore new therapeutic targets and provide innovative ideas for clinical treatment of sepsis.
- Protein lactylation modification,
- Sepsis,
- Multiple organ dysfunction

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References(39)

References

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