Inhibitory Effect of Low-Molecular-Weight Heparin and Insulin Supplemented with Fenofibrate Capsules on Local Inflammation in Patients with Hypertriglyceridemic Acute Pancreatitis

Yao TANG; Ting XU; Jun WU

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Yao TANG, Ting XU, Jun WU. Inhibitory Effect of Low-Molecular-Weight Heparin and Insulin Supplemented with Fenofibrate Capsules on Local Inflammation in Patients with Hypertriglyceridemic Acute Pancreatitis[J]. Journal of Kunming Medical University.

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Inhibitory Effect of Low-Molecular-Weight Heparin and Insulin Supplemented with Fenofibrate Capsules on Local Inflammation in Patients with Hypertriglyceridemic Acute Pancreatitis

Yao TANG^1
,,
Ting XU^{2
,
,},
Jun WU³

1.
Department of General Surgery
2.
Department of Gastroenterology，Xi’an No.3 Hospital，The Affiliated Hosptial of Northwest University，Xi’an Shaanxi 710000
3.
Department of Neurology，Xi’an High-tech Hospital，Xi’an Shaanxi 710000，China

Received Date: 2025-07-17
Available Online: 2025-10-08

Abstract

Abstract

Objective To investigate the effect of low-molecular-weight heparin, insulin, combined with fenofibrate on local inflammation in patients with hyperlipidemic acute pancreatitis （HL-SAP）. Methods 157 HL-SAP patients admitted to the Gastroenterology Department of Xi'an Third Hospital from January 2022 to February 2024 were enrolled and randomly divided into a conventional group （n = 79） and a combined group （n = 78）. The conventional group received standard treatment combined with fenofibrate capsules, while the combined group received standard treatment combined with low-molecular-weight heparin, insulin supplemented with fenofibrate capsules. The symptoms, blood lipid levels, inflammatory factors, liver and kidney functions, pancreatic enzyme indicators, MCTSI scores, pancreatic edema, local complications, adverse reactions and efficacy of the two groups were analyzed. Results Compared with the conventional group, the combined group showed significantly improved effectiveness （P < 0.05）. After one week of treatment, the combined group had shorter times for abdominal pain relief, peritoneal sign resolution, gastrointestinal function recovery, and hospital stay （P < 0.05）. The combined group showed better improvements in TC, TG, CRP, TNF-α, IL-6, ALT, AST, Scr, BUN, LPS, AMS, APACHE II scores, and MCTSI scores compared to the conventional group （P < 0.05）. Pancreatic edema volume was smaller in the combined group, with superior improvement; complications and adverse reactions were lower in the combined group （P < 0.05）. Conclusion Low-molecular-weight heparin, insulin combined with fenofibrate capsules can effectively improve clinical outcomes in HL-SAP patients, reduce inflammatory factor levels, stabilize blood lipids, improve liver and kidney function and pancreatic enzyme indicators, reduce local pancreatic complications and adverse reactions, and demonstrate good clinical value and treatment safety, warranting further clinical promotion.
- Hyperlipidemic acute pancreatitis,
- Low-molecular-weight heparin,
- Insulin,
- Fenofibrate capsules,
- Blood lipids,
- Local inflammation

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References(28)

References

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