Efficacy of Butylphthalide Combined with Atorvastatin in the Treatment of Cerebral Infarction and Its Effects on the Expression of vWF，PAI-1 and Ve Cadherin in Vascular Endothelium

Kejiao LI; Zichen LIU; Sha CHANG; Xue SONG; Fang LI

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Kejiao LI, Zichen LIU, Sha CHANG, Xue SONG, Fang LI. Efficacy of Butylphthalide Combined with Atorvastatin in the Treatment of Cerebral Infarction and Its Effects on the Expression of vWF，PAI-1 and Ve Cadherin in Vascular Endothelium[J]. Journal of Kunming Medical University.

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Efficacy of Butylphthalide Combined with Atorvastatin in the Treatment of Cerebral Infarction and Its Effects on the Expression of vWF，PAI-1 and Ve Cadherin in Vascular Endothelium

Kejiao LI^1
,,
Zichen LIU^{1
,
,},
Sha CHANG¹,
Xue SONG²,
Fang LI²

1.
Department of Neurology
2.
Department of Laboratory Medicine，Langfang Fourth People’s Hospital，Langfang Hebei 065700，China

Received Date: 2025-04-16

Abstract

Abstract

Objective To analyze the efficacy of butylphthalide combined with atorvastatin in the treatment of cerebral infarction and its effect on the expression of vascular endothelial hemophilia factor （VWF）, prothrombin activator inhibitor-1 （PAI-1） and vascular endothelial cadherin （VE-cadherin）. Methods A total of 150 patients with cerebral infarction admitted to Langfang Fourth People's Hospital from October 2021 to October 2023 were randomly assigned into two groups （75 cases each）. The control group received atorvastatin alone, while the experimental group was treated with butylphthalide combined with atorvastatin. The therapeutic efficacy, cerebral blood flow status, plaque stability index, vascular endothelial function index and treatment safety of the two groups were compared between the two groups. Results The total effective rate in the experimental group （90.67%） was higher than that in the control group （（74.67%, P < 0.05）. After treatment, the improvement in hemodynamic indicators in the experimental group was greater than that in the control group （P < 0.05）. After treatment, the carotid intima-media thickness （IMT）, plaque thickness and plaque area in the experimental group were lower than those in the control group （P < 0.05）. After the treatment, the MRI examination indicators in the experimental group included a higher fibrous cap and a lower lipid core than the control group （P < 0.05）. Additionally, the expression levels of vWF, PAI-1 and ve cadherin in the experimental group were lower than those in the control group （P < 0.05）. During a 1-year follow-up, the scores of Stroke Quality of Life Scale （SS-QOL） in the experimental group were higher than those in the control group （P < 0.05）. No statistically significant difference was observed in the incidence of adverse reactions between the two groups （P > 0.05）. Conclusion The combination of atorvastatin and butylphthalide is effective in the treatment of cerebral infarction. This therapeutic approach not only helps to improve cerebral blood flow state but also enhances the stability of carotid atherosclerotic plaque. It positively modulates vascular endothelial function and has a high safety profile.
- Cerebral infarction,
- Atorvastatin,
- Butylphthalide,
- Vascular endothelium,
- Hemodynamics,
- Plaque stability

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References(21)

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