Traditional Chinese Medicine Targeting the Wnt/β-Catenin Signaling Pathway to Modulate Neuroinflammation in Alzheimer's Disease

Lanxi FANG; Guanlin LIU; Weiyan HU; Ping GAN

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Lanxi FANG, Guanlin LIU, Weiyan HU, Ping GAN. Traditional Chinese Medicine Targeting the Wnt/β-Catenin Signaling Pathway to Modulate Neuroinflammation in Alzheimer's Disease[J]. Journal of Kunming Medical University.

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Traditional Chinese Medicine Targeting the Wnt/β-Catenin Signaling Pathway to Modulate Neuroinflammation in Alzheimer's Disease

Lanxi FANG^{1, 2},
Guanlin LIU^{1, 2},
Weiyan HU³,
Ping GAN^{1
,
,}

1.
School of Basic Medicine，Kunming Medical University，Kunming Yunnan 650500
2.
The First Clinical School of Kunming Medical University，Kunming Yunnan 650500
3.
School of Pharmaceutical Sciences，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2026-04-10

Abstract

Abstract

Under the increasingly severe aging demographics, neurodegenerative diseases such as Alzheimer’ s disease （AD） pose serious threats to population health. AD is characterized by progressive cognitive decline and memory loss. Its pathogenic mechanisms are complex, featuring a prolonged disease course and pathological characteristics that encompass multiple aspects, including β-amyloid protein deposition, tau protein hyperphosphorylation, neuroinflammatory responses, and oxidative stress, presenting formidable challenges for AD prevention and treatment. Currently, monoclonal antibody-based targeted therapeutics for AD not only show limited efficacy but are also associated with significant adverse effects. In contrast, traditional Chinese medicine, utilizing its multi-component and multi-target systemic regulatory advantages, exhibits unique potential in intervening in the complex pathological processes of AD, particularly in modulating neuroinflammatory responses. This article systematically reviews the central role of the Wnt/β-catenin signaling pathway in regulating neuroinflammation in Alzheimer's disease and summarizes recent research advances in the treatment of AD by traditional Chinese medicine and its active components through intervention in this pathway, aiming to provide novel theoretical evidence and strategic references for AD prevention and treatment.
- Alzheimer’ s disease,
- Wnt/β-catenin signaling pathway,
- Traditional Chinese medicine,
- Neuroinflammation

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References(53)

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