The Effectiveness of Liraglutide Combined with Metformin in Improving Glycolipid Metabolism and Hormonal Levels in Polycystic Ovary Syndrome: A Meta-Analysis

Xiaohui GU; Fenrong LV; Ju SUN; Yaping PENG; Dandan WAN

Article Contents

Article Navigation > Journal of Kunming Medical University > 2024 >

Xiaohui GU, Fenrong LV, Ju SUN, Yaping PENG, Dandan WAN. The Effectiveness of Liraglutide Combined with Metformin in Improving Glycolipid Metabolism and Hormonal Levels in Polycystic Ovary Syndrome: A Meta-Analysis[J]. Journal of Kunming Medical University.

Citation:

PDF( 5162 KB)

The Effectiveness of Liraglutide Combined with Metformin in Improving Glycolipid Metabolism and Hormonal Levels in Polycystic Ovary Syndrome: A Meta-Analysis

1.
Dept. General Medicine/Geriatrics，Qujing Second People’s Hospital，Qujing Yunnan 655099
2.
School of Clinical Medicine，Qujing Medical College，Qujing Yunnan 655100，China

Received Date: 2024-06-01
Available Online: 2024-10-14

Abstract

Abstract

Objective To systematically evaluate the effects of liraglutide combined with metformin on glucose and lipid metabolism, sex hormones, reproductive function, and gastrointestinal reactions in patients with polycystic ovary syndrome （PCOS）. Methods We searched databases such as PubMed, WanFang Medical Network, WanFang Database, China National Knowledge Infrastructure（CNKI）, and VIP Journals to collect randomized controlled trials published from January 2011 to August 2022 on the treatment of polycystic ovary syndrome with liraglutide combined with metformin, using Revman 5.4 for the meta-analysis. Results A total of 16 case-control studies were included, involving 1, 436 patients. Compared to metformin alone, the combination of liraglutide and metformin significantly lowered fasting blood sugar, postprandial blood glucoseafter 2 hours, HbA1c, HOMA-IR, FINS, BMI, as well as LH, FSH, and total testosterone in patients with PCOS. It improved lipid levels, helped establish menstrual cycles, and increased the normal ovulation rate and natural conception rate in these patients. However, there was a significantly higher incidence of gastrointestinal reactions in the liraglutide plus metformin group, and the difference was statistically significant （P < 0.05）. Conclusion: The combination of liraglutide and metformin can improve glucose and lipid metabolism in patients with polycystic ovary syndrome （PCOS）, reduce levels of LH, FSH, and total testosterone, help establish regular menstrual cycles, and increase ovulation and pregnancy rates, but it significantly increases gastrointestinal side effects.
- Liraglutide,
- Metformin,
- Polycystic ovary syndrome,
- Glycolipid metabolism

FullText(HTML)

References(28)

References

[1]	Tzotzas T,Karras S N,Katsiki N. Glucagon-like peptide-1 (GLP-1) receptor agonists in the treatment of obese women with polycystic ovary syndrome[J]. Curr Vasc Pharmacol,2017,15(3):218-229. doi: 10.2174/1570161114666161221115324
[2]	Pani A,Gironi I,Di Vieste G,et al. From prediabetes to type 2 diabetes mellitus in women with polycystic ovary syndrome: Lifestyle and pharmacological management[J]. International Journal of Endocrinology,2020,7(8):1-10.
[3]	Siamashvili M ,Davis S N. Update on the effects of GLP-1 receptor agonists for the treatment of polycystic ovary syndrome[J]. Expert Rev Clin Pharmacol,2021,14(9): 1081-1089.
[4]	黄昭穗,栾丽丽,杨骄,等. 利拉鲁肽对多囊卵巢综合征合并糖耐量异常及肥胖患者的代谢及受孕的影响[J]. 中华糖尿病杂志,2015,7(7):437-441. doi: 10.3760/cma.j.issn.1674-5809.2015.07.009
[5]	郝建民,卢涛,邱娟,等. 利拉鲁肽提高肥胖不孕多囊卵巢综合征妇女临床妊娠率的研究[J]. 实用药物与临床,2020,23(1):51-58.
[6]	郑亮,黎淑贞 ,林小玲. 利拉鲁肽联合二甲双胍治疗多囊卵巢综合征患者糖脂代谢紊乱及生殖功能异常[J]. 吉林医学,2022,43(9): 2442-2444.
[7]	赵丹. 利拉鲁肽联合二甲双胍治疗2型糖尿病合并多囊卵巢综合征的临床效果观察[J]. 中国现代医生,2019,57(9):43-45,55.
[8]	谭明灯,崔小平 ,陈平. 利拉鲁肽联合二甲双胍对肥胖型多囊卵巢综合征患者糖脂代谢及生殖功能的影响[J]. 中国计划生育和妇产科,2022,14(9): 74-78.
[9]	王爱媛,吕月,卢雅丹,等. 利拉鲁肽联合二甲双胍治疗2型糖尿病合并多囊卵巢综合征的临床效果观察[J]. 实用妇科内分泌电子杂志,2020,7(35): 34-41.
[10]	杨莉,邓赫男,谭琛,等. 利拉鲁肽辅助治疗多囊卵巢综合征的效果及对卵巢功能的影响[J]. 医学理论与实践,2022,35(10):1712-1714.
[11]	杨茜,张海雄,韩雪梅,等. 利拉鲁肽治疗对肥胖多囊卵巢综合征患者生育功能的影响[J]. 川北医学院学报,2021,36(12):1634-1637. doi: 10.3969/j.issn.1005-3697.2021.12.023
[12]	张波. 利拉鲁肽联合盐酸二甲双胍治疗多囊卵巢综合征伴糖脂代谢紊乱的临床效果[J]. 中国当代医药,2019,26(32):36-38. doi: 10.3969/j.issn.1674-4721.2019.32.011
[13]	苑光彩. 利拉鲁肽治疗2型糖尿病合并多囊卵巢综合征的临床价值研究[J]. 糖尿病新世界,2021,24(1):14-16.
[14]	孙海云,胡玉宏 ,徐水芳. 利拉鲁肽联合二甲双胍对多囊卵巢综合征患者卵巢功能的影响[J]. 现代药物与临床,2021,36(8): 1654-1658.
[15]	孙晖. 利拉鲁肽联合二甲双胍对2型糖尿病合并多囊卵巢综合征患者代谢和内分泌参数的影响研究[J]. 实用妇科内分泌电子杂志,2020,7(3): 16,21.
[16]	仉媛媛,韩晓璐,刘鸿丽,等. 应用利拉鲁肽对中心性肥胖和非中心性肥胖多囊卵巢综合征患者生殖内分泌及糖脂代谢的改善分析[J]. 饮食保健,2020,7(24):21-22.
[17]	Salamun V,Jensterle M,Janez A,et al. Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: A pilot randomized study[J]. Eur J Endocrinol,2018,179(1):1-11. doi: 10.1530/EJE-18-0175
[18]	Jensterle Sever M,Kocjan T,Pfeifer M,et al. Short-term combined treatment with liraglutide and metformin leads to significant weight loss in obese women with polycystic ovary syndrome and previous poor response to metformin[J]. Eur J Endocrinol,2014,170(3):451-459. doi: 10.1530/EJE-13-0797
[19]	Xing C,Zhao H,Zhang J,et al. Effect of metformin versus metformin plus liraglutide on gonadal and metabolic profiles in overweight patients with polycystic ovary syndrome[J]. Front Endocrinol (Lausanne),2022,8(17):421-429.
[20]	柳丽佳,邵铜,方媛,等. 1990—2019年中国多囊卵巢综合征发病趋势分析[J]. 中国预防医学杂志,2023,24(3):259-263.
[21]	Del Olmo-Garcia M I,Merino-Torres J F. GLP-1 receptor agonists and cardiovascular disease in patients with type 2 diabetes[J]. J Diabetes Res,2018,4(2):492-503.
[22]	McCreight L J,Bailey C J ,Pearson E R. Metformin and the gastrointestinal tract[J]. Diabetologia,2016,59(3): 426-435.
[23]	Conway G,Dewailly D,Diamanti-Kandarakis E,et al. European survey of diagnosis and management of the polycystic ovary syndrome: Results of the ESE PCOS Special Interest Group's Questionnaire[J]. Eur J Endocrinol,2014,171(4):489-498. doi: 10.1530/EJE-14-0252
[24]	Long X,Liu H,Xiong W,et al. Low dose of liraglutide combined with metformin leads to a significant weight loss in Chinese Han women with polycystic ovary syndrome: A retrospective study[J]. Gynecol Endocrinol,2023,39(1):648-657.
[25]	Jensterle M,Kravos N A,Goričar K,et al. Short-term effectiveness of low dose liraglutide in combination with metformin versus high dose liraglutide alone in treatment of obese PCOS: Randomized trial[J]. BMC Endocr Disord,2017,17(1):51-59. doi: 10.1186/s12902-017-0201-7
[26]	Lim S S,Hutchison S K,Van Ryswyk E,et al. Lifestyle changes in women with polycystic ovary syndrome[J]. Cochrane Database Syst Rev,2019,3(3):506-512.
[27]	Glueck C J ,Goldenberg N. Characteristics of obesity in polycystic ovary syndrome: Etiology,treatment,and genetics[J]. Metabolism,2019,92(3): 108-120.
[28]	Sikirica M V,Martin A A,Wood R,et al. Reasons for discontinuation of GLP1 receptor agonists: data from a real-world cross-sectional survey of physicians and their patients with type 2 diabetes[J]. Diabetes Metab Syndr Obes,2017,9(10):403-412.

Relative Articles(20)

Relative Articles

[1]	Limei HE, Xuemin FENG, Linjun LI, Ying CHEN, Zexing YANG. Changes of Sex Hormone Levels in Infertile Population with Polycystic Ovary Syndrome after the Assisted Reproductive Technology Treatment. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20240106
[2]	Ziwei ZHANG, Jialin ZHENG, Xiaoyu XU, Hong WANG. Metformin Inhibits high Glucose-induced Vascular Smooth Muscle Cells Proliferation by Promoting Autophagy via AMPK/PPAR-γ. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20231026
[3]	Xiaowei YUAN, Maohua QIN, Lijun WANG, Yuanqi DUAN. Expression of CRP，IL-6 and TNF-a in Serum of Patients with Adolescence Polycystic Ovary Syndrome. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20221026
[4]	Xiaowei YUAN, Maohua QIN, Lijun WANG, Tingxian YANG, Jing JIN. Expression Characteristics of Inflammatory Factors in the Serum of Patients with Adolescence Polycystic Ovary Syndrome. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20220517
[5]	Zheng-jiao DONG, Wen-que ZHANG, Lin-na YANG, Xue-hui HUANG, Yi-yan ZHANG, Wen-yang ZHANG, Jing-jing ZHANG. Quality of Life and Its Influencing Factors in Han Nationality Patients with Polycystic Ovary Syndrome. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210508
[6]	Ting ZHAO, Hong-rong WANG, Zheng-jiao DONG, Mei-xiu GAO, Dong-yan REN, Tao YUAN. Clinical Analysis of Vaginal Microecology in Patients with Polycystic Ovary Syndrome. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210113
[7]	Guo-qiang XUE, Xin-xin WEI, Na YAO, Wen-hua ZHAO. Metformin Protects Type II Diabetic Kidneys by Regulating PARP-1 Activity. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210632
[8]	Yang Huai Yong , Li Lin Da . . Journal of Kunming Medical University,
[9]	Jiang Ting Ting . The Relationship Between Polycystic Ovary Syndrome and Vaspin，Apelin and Leptin. Journal of Kunming Medical University,
[10]	Tian Wei . Liraglutide Improves The Symptoms of Non-alcoholic Fatty Liver Disease by Regulating Fatty Acid β-oxidation. Journal of Kunming Medical University,
[11]	Qiu Mei . Unnecessity of Integrating Metabolic Indices into the Diagnosis of Polycystic Ovary Syndrome. Journal of Kunming Medical University,
[12]	Liu Rong . . Journal of Kunming Medical University,
[13]	Liu Li Xin . . Journal of Kunming Medical University,
[14]	Yang Ying . . Journal of Kunming Medical University,
[15]	Qiu Hong Mei . . Journal of Kunming Medical University,
[16]	. . Journal of Kunming Medical University,
[17]	. Two-dimensional Strain Echocardiography to Assess Left Ventricular Systolic Function in Patients with Metabolic Syndrome. Journal of Kunming Medical University,
[18]	. Retrospective Analysis on Glucolipid Metabolism of 64 Patients with Liver Cirrhosis after Treatment with Recombinant Growth Hormone. Journal of Kunming Medical University,
[19]	. Clinical Effects of Metformin Combined with Clomiphene in Treament of PCOS after Laparoscopic Ovarian Drilling. Journal of Kunming Medical University,
[20]	Qiu Hong Mei . . Journal of Kunming Medical University,