Clinical Efficacy of Intrapleural Injection of Thrombin Combined with Drainage tube Suspension in the Treatment of Refractory Pneumothorax

Zhongqiang ZHANG; Lili HU; Junli CHEN

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Zhongqiang ZHANG, Lili HU, Junli CHEN. Clinical Efficacy of Intrapleural Injection of Thrombin Combined with Drainage tube Suspension in the Treatment of Refractory Pneumothorax[J]. Journal of Kunming Medical University.

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Clinical Efficacy of Intrapleural Injection of Thrombin Combined with Drainage tube Suspension in the Treatment of Refractory Pneumothorax

1.
Dept. of Thoracic Surgery，The 1st Hospital of Handan，Hebei Handan 056001，China

Received Date: 2023-09-18

Abstract

Abstract

Objective To observe the clinical effect of intrathoracic thrombin injection combined with drainage tube suspension in the treatment of refractory pneumothorax. Methods Data of 52 patients with refractory pneumothorax who received continuous closed thoracic drainage in the hospital and were assisted by conventional medical treatment with continuous negative pressure suction from January 2020 to February 2022 were included as the control group. The data of 60 patients with refractory pneumothorax who received intrathoracic thrombin injection combined with drainage tube suspension treatment in the same period were included as the observation group. After 3 weeks of treatment, the clinical efficacy, clinical indicators （incidence of inflammation, pulmonary infection, pulmonary dysfunction and irritating cough）, immune function indicators [mature T lymphocytes （CD3⁺）, induced T cells/helper T cells （CD4⁺）, inhibitory T cells/cytotoxic T cells （CD8⁺）] and the occurrence of adverse drug reactions were compared between the two groups. Results After 3 weeks of treatment, the effective rates of the observation group and the control group were 96.67% （58/60） and 82.69% （43/52） respectively （P < 0.05）. After 3 weeks of treatment, the clinical indicators （incidence of inflammation, pulmonary infection, pulmonary dysfunction and irritating cough） in the observation group were better than those in the control group, with statistical significance （P < 0.05）. After 3 weeks of treatment, the immune function indexes （mature T lymphocytes （CD3⁺）, induced T cells/helper T cells （CD4⁺） and inhibited T cells/cytotoxic T cells （CD8⁺）） in both groups increased, and the difference was statistically significant （P < 0.05）. There were no adverse reactions in the control group and the observation group during treatment, and the difference was not statistically significant （P > 0.05）. Conclusion Intrathoracic thrombin injection combined with drainage tube suspension has a good clinical effect and a high cure rate in the treatment of refractory pneumothorax.
- Thrombin,
- Drainage tube suspension,
- Refractory pneumothorax,
- Clinical efficacy

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References(20)

References

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