Early Warning Value of Netrin-1，miR-144 and miR-21 for Miscarriage in Patients with PCOS Infertility

Yi ZENG; Honggui PAN; Binmei LONG

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Yi ZENG, Honggui PAN, Binmei LONG. Early Warning Value of Netrin-1，miR-144 and miR-21 for Miscarriage in Patients with PCOS Infertility[J]. Journal of Kunming Medical University.

Citation:

Yi ZENG, Honggui PAN, Binmei LONG. Early Warning Value of Netrin-1，miR-144 and miR-21 for Miscarriage in Patients with PCOS Infertility[J]. Journal of Kunming Medical University.

Yi ZENG, Honggui PAN, Binmei LONG. Early Warning Value of Netrin-1，miR-144 and miR-21 for Miscarriage in Patients with PCOS Infertility[J]. Journal of Kunming Medical University.

Citation:

Yi ZENG, Honggui PAN, Binmei LONG. Early Warning Value of Netrin-1，miR-144 and miR-21 for Miscarriage in Patients with PCOS Infertility[J]. Journal of Kunming Medical University.

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Early Warning Value of Netrin-1，miR-144 and miR-21 for Miscarriage in Patients with PCOS Infertility

1.
Department of Obstetrics，Nanchong Central Hospital，Nanchong Sichuan 637000
2.
Department of Obstetrics and Gynecology，Da Yi County Women's and Children's Hospital，Da Yi Sichuan 611300，China

Received Date: 2026-02-04

Abstract

Abstract

Objective To investigate the serum expression levels of neuroaxon guidance factor-1 （Netrin-1）, microRNA-144 （miR-144）, and microRNA-21 （miR-21） in infertile patients with polycystic ovary syndrome （PCOS） and their combined predictive value for miscarriage. Methods The clinical data of 238 PCOS infertility patients who underwent in vitro fertilization and embryo transfer （IVF/icf-et） and had successful clinical pregnancy in Nanchong Central Hospital from August 2020 to August 2023 were collected and retrospectively analyzed. The mixed interference of age, basic endocrine profiles, the number of embryo transferred and the quality of embryos was studied to ensure the objectivity of the conclusion. According to the early pregnancy miscarriage, the patients were divided into a miscarriage group （n = 60） and a non-miscarriage group （n = 178）. The general data and the serum expression levels of Netrin-1, miR-144 and miR-21 were compared between the two groups. Logistic regression equation was used to analyze the influencing factors of miscarriage in patients with PCOS infertility. The receiver operating characteristic curve （ROC） was drawn to analyze the predictive value of serum Netrin-1, miR-144 and miR-21 expression in predicting miscarriage in patients with PCOS infertility. Results BMI and the proportion of insulin resistance in the miscarriage group were higher than those in the non-miscarriage group, and LH levels was higher than that in the non-miscarriage group （P < 0.05）. The serum levels of Netrin-1 and miR-144 in the miscarriage group were lower than those in the non-miscarriage group, while miR-21 was higher than those in the non-miscarriage group （P < 0.05）. BMI, insulin resistance, LH, Netrin-1, miR-144, and miR-21 were all influencing factors for miscarriage in PCOS infertility patients （P < 0.05）. The AUC for the combined prediction of serum Netrin-1, miR-144 and miR-21 in predicting miscarriage in infertile patients with PCOS was 0.938, which was higher than that of single prediction AUC of 0.763, 0.772 and 0.760 （P < 0.05）. Conclusion Netrin-1, mir-144 and miR-21 are the influencing factors for miscarriage in patients with PCOS infertility. The combined detection of netrin-1, mir-144 and miR-21 is helpful to improve the predictive value for miscarriage, and can provide evidence-based support for the reproductive centers to establish a stratified management system for early pregnancy in PCOS assisted pregnancy population.
- Polycystic ovary syndrome,
- Infertile,
- Neural axon guidance factor-1,
- MicroRNA-144,
- MicroRNA-21

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References(25)

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