Studies on the Correlation between Esophageal Manometry and Short-Term Efficacy of Endoscopic Myomectomy in Patients with Achalasia

Yingye SONG; Juanping LI; Rui LI

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Yingye SONG, Juanping LI, Rui LI. Studies on the Correlation between Esophageal Manometry and Short-Term Efficacy of Endoscopic Myomectomy in Patients with Achalasia[J]. Journal of Kunming Medical University.

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Yingye SONG, Juanping LI, Rui LI. Studies on the Correlation between Esophageal Manometry and Short-Term Efficacy of Endoscopic Myomectomy in Patients with Achalasia[J]. Journal of Kunming Medical University.

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Studies on the Correlation between Esophageal Manometry and Short-Term Efficacy of Endoscopic Myomectomy in Patients with Achalasia

Yingye SONG^{1, 2},
Juanping LI^{1, 2},
Rui LI^{1, 2
,
,}

1.
Department of The First Affiliated Hospital of Soochow University，Suzhou Jiangsu 215006
2.
Department of Gastroenterology，The Seventh People's Hospital of Changzhou City Changzhou，Jiangsu Changzhou 213011，China

Received Date: 2025-04-25
Available Online: 2025-08-13

Abstract

Abstract

Objective To investigate the correlation between esophageal manometry and short-term efficacy of Preoral endoscopic myotomy in patients with achalasia of cardia （AC）. Methods Clinical data of AC patients who underwent POEM treatment for the first time in the Department of Gastroenterology at The First Affiliated Hospital of Soochow University from January 2019 to September 2024 were selected and grouped based on the 2020 Chicago 4.0 and Ling classifications. Baselin e data and surgical response rates of the patients were analyzed so as to compare Eckardt scores and esophageal manometry data of patients in different groupsand analyze the correlation between esophageal manometry data and postoperative clinical efficacy. Results （1） , The surgical success rate of 272 patients included in this study was 100%. The preoperative Eckardt score was （6.65 ± 1.48） points, and the Eckardt score 3 months after the surgery was （1.05 ± 0.56） points. The Eckardt score after POEM surgery decreased significantly compared to preoperative levels, and the difference was statistically significant （t = 19.823, P < 0.001）. The postoperative Eckardt scores of the three groups of patients classified by Chicago and the five groups of patients classified by Ling were significantly lower than those before the surgery, and the differences were statistically significant （P < 0.05）. （2） The postoperative LESP and 4SIRP of the three groups of patients classified by Chicago were significantly reduced compared with preoperative levels, and the differences were statistically significant （P < 0.05）. And there was a statistically significant difference in the postoperative LESP and 4SIRP among the three groups of patients （P < 0.05）; Further comparison using Bonferroni method showed that the LESP and 4SIRP of Group II were lower than those of Group I and Group III （both P < 0.05）, but there was no statistically significant difference between Group I and Group III （both P > 0.05）. The postoperative LESP and 4SIRP of the five groups of patients classified by Ling were also lower than those before the surgery, and the comparison was statistically significant （P < 0.05）. There was also a statistically significant difference （P < 0.05） in the postoperative LESP and 4SIRP among the five groups of patients; Further comparison using Bonferroni method showed that the LESP and 4SIRP of groups IIa, IIb, IIc, and III were significantly lower than those of group I （all P < 0.05）, but there was no statistically significant difference between groups IIa, IIb, IIc, and III （all P > 0.05）. （3） The severity of 4SIRP and Eckardt scores showed a moderate correlation （r = 0.428, P = 0.001）; The severity of LESP and Eckardt scores showed a mild correlation （r = 0.245, P = 0.004）. Conclusion The short-term clinical efficacy of POEM treatment for AC is significant, with Chicago type II AC patients showing the best response to POEM treatment. Ling’ s classification of type IIa, IIb, IIc, and III shows better efficacy than type I; Moreover, there is a moderate correlation between the 4SIRP and Eckardt scores in the HRM parameters, which has good evaluation value for the postoperative efficacy of POEM.
- Achalasia of cardia,
- High resolution esophageal manometry,
- Preoral endoscopic myotomy

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References(25)

References

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