Clinical Characteristics and Prognostic Analysis of Maintenance Hemodialysis Patients With Initial Treatment Tuberculosis

Haixia GU; Jiangli PENG; anxin CHEN; Rui YIN; qiqi XIAO; Jie CHEN

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Haixia GU, Jiangli PENG, anxin CHEN, Rui YIN, qiqi XIAO, Jie CHEN. Clinical Characteristics and Prognostic Analysis of Maintenance Hemodialysis Patients With Initial Treatment Tuberculosis[J]. Journal of Kunming Medical University.

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Clinical Characteristics and Prognostic Analysis of Maintenance Hemodialysis Patients With Initial Treatment Tuberculosis

1.
College of Pharmacy，Dali University，Dali Yunnan 671000
2.
Dept.of Pharmacy，Kunming 3rd People's Hospital，Kunming Yunnan 650041，China

Abstract

Abstract

Objective To analyze the clinical characteristics, treatment and prognosis of patients undergoing maintenance hemodialysis and treatment-naive tuberculosis, and to explore the prognostic factors, so as to provide a reference for the clinical treatment of patients undergoing hemodialysis and tuberculosis. Methods The clinical data of 70 patients with hemodialysis and treatment-naive tuberculosis admitted to the Third People's Hospital of Kunming from October 31, 2020～October 31, 2023 were retrospectively collected, and the clinical characteristics of the patients were analyzed, and the occurrence of adverse reactions, treatment outcomes and prognostic factors were observed. Results Among the 70 patients, pulmonary tuberculosis was the primary type （64 cases, accounting for 91.43%）, and extrapulmonary tuberculosis was also quite common （56 cases, accounting for 80.00%）. The most widely used anti-tuberculosis regimen is isoniazid, rifampicin, ethambutol, and moxifloxacin in a four-drug combination; During anti-tuberculosis treatment, 55 patients （78.57%） improved. A total of 13 adverse reactions occurred in 11 patients （15.71%）, and the most common ones were itching, rash and blurred vision. The hemoglobin, lymphocyte count and CD8⁺ T lymphocyte count in the treatment improvement group were higher than those in the ineffective group （P < 0.05）. Conclusion Dialysis patients have a high risk of tuberculosis infection, mainly pulmonary tuberculosis, and extrapulmonary tuberculosis is more common. 78.57% of the patients had improved tuberculosis treatment, and the overall prognosis was poor, and the low hemoglobin level was associated with ineffective treatment.
- tuberculosis,
- Hemodialysis,
- chronic kidney disease,
- clinical features,
- Treat,
- prognosis

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