Analysis of the Correlation Between miR-125b-5p，Cardiac Function，and Myocardial Injury in Patients with HFpEF

Lu CHEN; Na PANG; Huijing ZHANG; Mengen ZHAI

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Lu CHEN, Na PANG, Huijing ZHANG, Mengen ZHAI. Analysis of the Correlation Between miR-125b-5p，Cardiac Function，and Myocardial Injury in Patients with HFpEF[J]. Journal of Kunming Medical University.

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Lu CHEN, Na PANG, Huijing ZHANG, Mengen ZHAI. Analysis of the Correlation Between miR-125b-5p，Cardiac Function，and Myocardial Injury in Patients with HFpEF[J]. Journal of Kunming Medical University.

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Analysis of the Correlation Between miR-125b-5p，Cardiac Function，and Myocardial Injury in Patients with HFpEF

Department of Cardiology，Hengshui People’s Hospital，Hengshui Hebei 053000，China

Received Date: 2025-12-29

Abstract

Abstract

Objective To investigate the correlation between serum microRNA-125b-5p （miR-125b-5p）, cardiac function indexes and myocardial injury in patients with heart failure with preserved ejection fraction （HFpEF）, and their predictive value for major adverse cardiovascular events （MACEs）. Methods A total of 225 patients with HFpEF treated in Hengshui People’s Hospital from December 2023 to April 2025 were selected. According to New York Heart Association （NYHA） cardiac function classification, they were divided into class Ⅱ group （67 cases）, class Ⅲ group （98 cases） and class Ⅳ group （60 cases）. Serum miR-125b-5p, cardiac troponin I （cTnI）, N-terminal pro-B-type natriuretic peptide （NT-proBNP）, left ventricular ejection fraction （LVEF）, left ventricular end-diastolic diameter （LVEDD）, left ventricular mass index （LVMI）, T1 mapping and extracellular volume fraction （ECV） were detected in each group. All patients were followed up for 12 months, and the occurrence of MACEs was recorded. The patients were divided into MACEs group （67 cases） and non-MACEs group （158 cases）. Collect clinical data from patients in each group and compare levels of serum miR-125b-5p, cardiac function, and markers of myocardial injury; Pearson correlation analysis of the relationship between miR-125b-5p, cardiac function-related indicators, and myocardial injury; Multivariate logistic regression analysis was performed to identify risk factors for MACE in patients with HFpEF; receiver operating characteristic （ROC） curves were used to evaluate the predictive value of miR-125b-5p and cardiac function indices for cardiovascular adverse events in patients with HFpEF. Results Compared with the Class II group, the Class III and IV groups showed decreased LVEF and miR-125b-5p levels, as well as elevated levels of cardiac troponin I （cTnI）, N-terminal pro-B-type natriuretic peptide （N-terminal pro-B-type natriuretic peptide, NT-proBNP）, left ventricular end-diastolic diameter （LVEDD）, and left ventricular mass index （LVMI）, while T1 mapping and extracellular volume fraction （ECV） values were all elevated; Compared with the Grade III group, the Grade IV group showed decreased levels of miR-125b-5p and left ventricular ejection fraction （LVEF）, as well as increased levels of cTnI, NT-proBNP, LVEDD, and LVMI, along with elevated T1 mapping and ECV values （P < 0.05）. Logistic regression analysis revealed that, after adjusting for confounding factors, LVEF, HDL-C, hematocrit, cTnI, NT-proBNP, and miR-125b-5p were all risk factors for the occurrence of MACE in patients with HFpEF; Pearson correlation analysis revealed that cTnI, NT-proBNP, T1 mapping, and ECV were negatively correlated with LVEF and miR-125b-5p, and positively correlated with LVMI and LVEDD （P < 0.05）. The ROC curve showed that the combined assessment of LVEF, LVMI, LVEDD, and miR-125b-5p had higher AUC values, sensitivity, and accuracy for predicting the occurrence of MACEs than any single parameter （P < 0.05）. Conclusion Patients with HFpEF have reduced serum miR-125b-5p levels and abnormal cardiac function parameters, which are associated with myocardial injury; combined testing of miR-125b-5p and cardiac function parameters has high predictive value for the occurrence of MACE in these patients.
- Chronic heart failure,
- Cardiac function,
- Myocardial injury,
- Oxidative stress

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References(24)

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